KEGG   Homo sapiens (human): 4512
Entry
4512              CDS       T01001                                 
Symbol
COX1, COI, MTCO1, MT-CO1
Name
(RefSeq) cytochrome c oxidase subunit I
  KO
K02256  cytochrome c oxidase subunit 1 [EC:7.1.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
Disease
H00068  Leber hereditary optic atrophy
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4512 (COX1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4512 (COX1)
  09159 Environmental adaptation
   04714 Thermogenesis
    4512 (COX1)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4512 (COX1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4512 (COX1)
   05012 Parkinson disease
    4512 (COX1)
   05014 Amyotrophic lateral sclerosis
    4512 (COX1)
   05016 Huntington disease
    4512 (COX1)
   05020 Prion disease
    4512 (COX1)
   05022 Pathways of neurodegeneration - multiple diseases
    4512 (COX1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4512 (COX1)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4512 (COX1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4512 (COX1)
Enzymes [BR:hsa01000]
 7. Translocases
  7.1  Catalysing the translocation of protons
   7.1.1  Linked to oxidoreductase reactions
    7.1.1.9  cytochrome-c oxidase
     4512 (COX1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4512 (COX1)
SSDB
Motif
Pfam: COX1
Other DBs
NCBI-GeneID: 4512
NCBI-ProteinID: YP_003024028
OMIM: 516030
HGNC: 7419
UniProt: P00395 U5YWV7
Structure
Position
MT:5904..7445
AA seq 513 aa
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTA
HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEA
GAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ
TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH
PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLAN
SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG
VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKR
KVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS
NT seq 1542 nt   +upstreamnt  +downstreamnt
atgttcgccgaccgttgactattctctacaaaccacaaagacattggaacactataccta
ttattcggcgcatgagctggagtcctaggcacagctctaagcctccttattcgagccgag
ctgggccagccaggcaaccttctaggtaacgaccacatctacaacgttatcgtcacagcc
catgcatttgtaataatcttcttcatagtaatacccatcataatcggaggctttggcaac
tgactagttcccctaataatcggtgcccccgatatggcgtttccccgcataaacaacata
agcttctgactcttacctccctctctcctactcctgctcgcatctgctatagtggaggcc
ggagcaggaacaggttgaacagtctaccctcccttagcagggaactactcccaccctgga
gcctccgtagacctaaccatcttctccttacacctagcaggtgtctcctctatcttaggg
gccatcaatttcatcacaacaattatcaatataaaaccccctgccataacccaataccaa
acgcccctcttcgtctgatccgtcctaatcacagcagtcctacttctcctatctctccca
gtcctagctgctggcatcactatactactaacagaccgcaacctcaacaccaccttcttc
gaccccgccggaggaggagaccccattctataccaacacctattctgatttttcggtcac
cctgaagtttatattcttatcctaccaggcttcggaataatctcccatattgtaacttac
tactccggaaaaaaagaaccatttggatacataggtatggtctgagctatgatatcaatt
ggcttcctagggtttatcgtgtgagcacaccatatatttacagtaggaatagacgtagac
acacgagcatatttcacctccgctaccataatcatcgctatccccaccggcgtcaaagta
tttagctgactcgccacactccacggaagcaatatgaaatgatctgctgcagtgctctga
gccctaggattcatctttcttttcaccgtaggtggcctgactggcattgtattagcaaac
tcatcactagacatcgtactacacgacacgtactacgttgtagcccacttccactatgtc
ctatcaataggagctgtatttgccatcataggaggcttcattcactgatttcccctattc
tcaggctacaccctagaccaaacctacgccaaaatccatttcactatcatattcatcggc
gtaaatctaactttcttcccacaacactttctcggcctatccggaatgccccgacgttac
tcggactaccccgatgcatacaccacatgaaacatcctatcatctgtaggctcattcatt
tctctaacagcagtaatattaataattttcatgatttgagaagccttcgcttcgaagcga
aaagtcctaatagtagaagaaccctccataaacctggagtgactatatggatgcccccca
ccctaccacacattcgaagaacccgtatacataaaatctaga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (14)   
   KEGG PATHWAY (13)   
   KEGG MODULE (1)   
Network (6)   
   KEGG NETWORK (6)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (37)   
   KEGG ORTHOLOGY (1)   
   RefGene (32)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (73)   

Download RDF
DBGET integrated database retrieval system