KEGG   Homo sapiens (human): 4513
Entry
4513              CDS       T01001                                 
Symbol
COX2, COII, MTCO2, MT-CO2
Name
(RefSeq) cytochrome c oxidase subunit II
  KO
K02261  cytochrome c oxidase subunit 2
Organism
hsa  Homo sapiens (human)
Pathway
hsa00190  Oxidative phosphorylation
hsa01100  Metabolic pathways
hsa04260  Cardiac muscle contraction
hsa04714  Thermogenesis
hsa04932  Non-alcoholic fatty liver disease
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05415  Diabetic cardiomyopathy
Module
hsa_M00154  Cytochrome c oxidase
Network
nt06252  Mitochondrial ROS formation (cancer)
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
  Element
N00998  Electron transfer in Complex IV
N00999  Mutation-caused aberrant Abeta to electron transfer in Complex IV
N01394  Arsenic to electron transfer in complex IV
Disease
H01368  Cytochrome c oxidase (COX) deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    4513 (COX2)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    4513 (COX2)
  09159 Environmental adaptation
   04714 Thermogenesis
    4513 (COX2)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    4513 (COX2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4513 (COX2)
   05012 Parkinson disease
    4513 (COX2)
   05014 Amyotrophic lateral sclerosis
    4513 (COX2)
   05016 Huntington disease
    4513 (COX2)
   05020 Prion disease
    4513 (COX2)
   05022 Pathways of neurodegeneration - multiple diseases
    4513 (COX2)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    4513 (COX2)
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    4513 (COX2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4513 (COX2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial DNA-encoded proteins
   Cytochrome c oxidase
    4513 (COX2)
SSDB
Motif
Pfam: COX2 COX2_TM Herpes_LAMP2 DUF3100 DPM3 NPCC
Other DBs
NCBI-GeneID: 4513
NCBI-ProteinID: YP_003024029
OMIM: 516040
HGNC: 7421
UniProt: P00403 U5Z487
Structure
Position
MT:7586..8269
AA seq 227 aa
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE
METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS
YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN
QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
NT seq 684 nt   +upstreamnt  +downstreamnt
atggcacatgcagcgcaagtaggtctacaagacgctacttcccctatcatagaagagctt
atcacctttcatgatcacgccctcataatcattttccttatctgcttcctagtcctgtat
gcccttttcctaacactcacaacaaaactaactaatactaacatctcagacgctcaggaa
atagaaaccgtctgaactatcctgcccgccatcatcctagtcctcatcgccctcccatcc
ctacgcatcctttacataacagacgaggtcaacgatccctcccttaccatcaaatcaatt
ggccaccaatggtactgaacctacgagtacaccgactacggcggactaatcttcaactcc
tacatacttcccccattattcctagaaccaggcgacctgcgactccttgacgttgacaat
cgagtagtactcccgattgaagcccccattcgtataataattacatcacaagacgtcttg
cactcatgagctgtccccacattaggcttaaaaacagatgcaattcccggacgtctaaac
caaaccactttcaccgctacacgaccgggggtatactacggtcaatgctctgaaatctgt
ggagcaaaccacagtttcatgcccatcgtcctagaattaattcccctaaaaatctttgaa
atagggcccgtatttaccctatag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (13)   
   KEGG MODULE (1)   
Network (6)   
   KEGG NETWORK (6)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
3D Structure (2)   
   PDB (2)   
Protein domain (6)   
   Pfam (6)   
All databases (48)   

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