KEGG   Homo sapiens (human): 4597
Entry
4597              CDS       T01001                                 
Symbol
MVD, FP17780, MDDase, MPD, POROK7
Name
(RefSeq) mevalonate diphosphate decarboxylase
  KO
K01597  diphosphomevalonate decarboxylase [EC:4.1.1.33]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00900  Terpenoid backbone biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00095  C5 isoprenoid biosynthesis, mevalonate pathway
Network
nt06034  Cholesterol biosynthesis
  Element
N01635  Mevalonate pathway
Disease
H01933  Porokeratosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    4597 (MVD)
Enzymes [BR:hsa01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.33  diphosphomevalonate decarboxylase
     4597 (MVD)
SSDB
Motif
Pfam: MDD_C GHMP_kinases_N
Other DBs
NCBI-GeneID: 4597
NCBI-ProteinID: NP_002452
OMIM: 603236
HGNC: 7529
Ensembl: ENSG00000167508
UniProt: P53602
Structure
Position
16:complement(88651940..88663091)
AA seq 400 aa
MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDF
TEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNFPT
AAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKD
SIARQVAPESHWPELRVLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEM
ARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKV
AYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQAALAM
EPTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLPKPAA
NT seq 1203 nt   +upstreamnt  +downstreamnt
atggcctcggagaagccgctggcggcagtcacttgtacagcgccggtcaacatcgcggtc
atcaagtactggggcaagcgcgatgaagagctggttctgcccatcaactcctccctgagc
gtcactctgcaccaggaccagttaaaaaccaccacaacagccgtcatcagcaaggacttc
accgaggaccggatttggctgaatggccgggaggaggatgtggggcagccgcggctgcag
gcctgcctgcgggagatccgctgcctggcccggaagcggaggaactcacgggatggggac
ccgctgccctccagcctcagctgcaaggtgcacgtggcatcggtgaacaacttccccacg
gctgcgggcctggcctcctcagcggcgggctatgcctgcctagcctacaccctggcccgt
gtctacggcgtggagagtgacctctcagaagtggctcgccggggctcaggcagcgcctgc
cggagcctgtatgggggctttgtggagtggcagatgggagagcaggccgacgggaaggac
agcatcgctcggcaagtggcccccgagtcacactggcctgaactccgcgtgctcatcctt
gtggtgagcgctgagaagaagctgacaggcagtaccgtgggcatgcgggccagtgtggag
accagccccctgcttcggttccgggccgagtccgtggtgcccgcgcgcatggcggagatg
gcccgctgcatccgggagcgagacttccccagcttcgcccagctgaccatgaaggacagc
aaccagttccacgccacctgcctcgacaccttcccgcccatctcttacctcaatgccatc
tcctggcgcatcatccacctggtgcaccgcttcaacgcccaccacggggacaccaaggtg
gcgtacacctttgacgcgggccccaatgccgtgatcttcaccctggacgacactgtggct
gagtttgtggctgctgtgtggcacggctttcccccaggctcgaatggagacacgtttctg
aaggggctgcaggtgaggccggcccctctctcagctgagcttcaggctgcgctggccatg
gagccgacccccggtggggtcaaatacatcattgtcactcaggtggggccagggcctcaa
atcctggatgacccctgcgcccacctcctgggtcctgacggcctgccgaagccagctgcc
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (23)   
   RefSeq(nuc) (9)   
   GenBank (7)   
   EMBL (7)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (72)   

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