KEGG   Homo sapiens (human): 47
Entry
47                CDS       T01001                                 
Symbol
ACLY, ACL, ATPCL, CLATP
Name
(RefSeq) ATP citrate lyase
  KO
K01648  ATP citrate (pro-S)-lyase [EC:2.3.3.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa01100  Metabolic pathways
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01604  Citrate cycle, first carbon oxidation
Drug target
Bempedoic acid: D10691<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    47 (ACLY)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    47 (ACLY)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.8  ATP citrate synthase
     47 (ACLY)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   47 (ACLY)
  Exosomal proteins of bladder cancer cells
   47 (ACLY)
  Exosomal proteins of melanoma cells
   47 (ACLY)
SSDB
Motif
Pfam: Citrate_bind Citrate_synt Ligase_CoA CoA_binding ATP-grasp_2 Succ_CoA_lig
Other DBs
NCBI-GeneID: 47
NCBI-ProteinID: NP_001087
OMIM: 108728
HGNC: 115
Ensembl: ENSG00000131473
UniProt: P53396
Structure
Position
17:complement(41866917..41930545)
AA seq 1101 aa
MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPD
QLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFY
VCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEI
LASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPP
PFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNE
LANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALG
HRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVP
SPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQK
FYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEG
IPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYV
SRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIG
GTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALK
EAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASF
MTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADH
GPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFV
NKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPN
LILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLK
QGLYRHPWDDISYVLPEHMSM
NT seq 3306 nt   +upstreamnt  +downstreamnt
atgtcggccaaggcaatttcagagcagacgggcaaagaactcctttacaagttcatctgt
accacctcagccatccagaatcggttcaagtatgctcgggtcactcctgacacagactgg
gcccgcttgctgcaggaccacccctggctgctcagccagaacttggtagtcaagccagac
cagctgatcaaacgtcgtggaaaacttggtctcgttggggtcaacctcactctggatggg
gtcaagtcctggctgaagccacggctgggacaggaagccacagttggcaaggccacaggc
ttcctcaagaactttctgatcgagcccttcgtcccccacagtcaggctgaggagttctat
gtctgcatctatgccacccgagaaggggactacgtcctgttccaccacgaggggggtgtg
gacgtgggtgatgtggacgccaaggcccagaagctgcttgttggcgtggatgagaaactg
aatcctgaggacatcaaaaaacacctgttggtccacgcccctgaagacaagaaagaaatt
ctggccagttttatctccggcctcttcaatttctacgaggacttgtacttcacctacctc
gagatcaatccccttgtagtgaccaaagatggagtctatgtccttgacttggcggccaag
gtggacgccactgccgactacatctgcaaagtgaagtggggtgacatcgagttccctccc
cccttcgggcgggaggcatatccagaggaagcctacattgcagacctcgatgccaaaagt
ggggcaagcctgaagctgaccttgctgaaccccaaagggaggatctggaccatggtggcc
gggggtggcgcctctgtcgtgtacagcgataccatctgtgatctagggggtgtcaacgag
ctggcaaactatggggagtactcaggcgcccccagcgagcagcagacctatgactatgcc
aagactatcctctccctcatgacccgagagaagcacccagatggcaagatcctcatcatt
ggaggcagcatcgcaaacttcaccaacgtggctgccacgttcaagggcatcgtgagagca
attcgagattaccagggccccctgaaggagcacgaagtcacaatctttgtccgaagaggt
ggccccaactatcaggagggcttacgggtgatgggagaagtcgggaagaccactgggatc
cccatccatgtctttggcacagagactcacatgacggccattgtgggcatggccctgggc
caccggcccatccccaaccagccacccacagcggcccacactgcaaacttcctcctcaac
gccagcgggagcacatcgacgccagcccccagcaggacagcatctttttctgagtccagg
gccgatgaggtggcgcctgcaaagaaggccaagcctgccatgccacaagattcagtccca
agtccaagatccctgcaaggaaagagcaccaccctcttcagccgccacaccaaggccatt
gtgtggggcatgcagacccgggccgtgcaaggcatgctggactttgactatgtctgctcc
cgagacgagccctcagtggctgccatggtctaccctttcactggggaccacaagcagaag
ttttactgggggcacaaagagatcctgatccctgtcttcaagaacatggctgatgccatg
aggaagcatccggaggtagatgtgctcatcaactttgcctctctccgctctgcctatgac
agcaccatggagaccatgaactatgcccagatccggaccatcgccatcatagctgaaggc
atccctgaggccctcacgagaaagctgatcaagaaggcggaccagaagggagtgaccatc
atcggacctgccactgttggaggcatcaagcctgggtgctttaagattggcaacacaggt
gggatgctggacaacatcctggcctccaaactgtaccgcccaggcagcgtggcctatgtc
tcacgttccggaggcatgtccaacgagctcaacaatatcatctctcggaccacggatggc
gtctatgagggcgtggccattggtggggacaggtacccgggctccacattcatggatcat
gtgttacgctatcaggacactccaggagtcaaaatgattgtggttcttggagagattggg
ggcactgaggaatataagatttgccggggcatcaaggagggccgcctcactaagcccatc
gtctgctggtgcatcgggacgtgtgccaccatgttctcctctgaggtccagtttggccat
gctggagcttgtgccaaccaggcttctgaaactgcagtagccaagaaccaggctttgaag
gaagcaggagtgtttgtgccccggagctttgatgagcttggagagatcatccagtctgta
tacgaagatctcgtggccaatggagtcattgtacctgcccaggaggtgccgcccccaacc
gtgcccatggactactcctgggccagggagcttggtttgatccgcaaacctgcctcgttc
atgaccagcatctgcgatgagcgaggacaggagctcatctacgcgggcatgcccatcact
gaggtcttcaaggaagagatgggcattggcggggtcctcggcctcctctggttccagaaa
aggttgcctaagtactcttgccagttcattgagatgtgtctgatggtgacagctgatcac
gggccagccgtctctggagcccacaacaccatcatttgtgcgcgagctgggaaagacctg
gtctccagcctcacctcggggctgctcaccatcggggatcggtttgggggtgccttggat
gcagcagccaagatgttcagtaaagcctttgacagtggcattatccccatggagtttgtg
aacaagatgaagaaggaagggaagctgatcatgggcattggtcaccgagtgaagtcgata
aacaacccagacatgcgagtgcagatcctcaaagattacgtcaggcagcacttccctgcc
actcctctgctcgattatgcactggaagtagagaagattaccacctcgaagaagccaaat
cttatcctgaatgtagatggtctcatcggagtcgcatttgtagacatgcttagaaactgt
gggtcctttactcgggaggaagctgatgaatatattgacattggagccctcaatggcatc
tttgtgctgggaaggagtatggggttcattggacactatcttgatcagaagaggctgaag
caggggctgtatcgtcatccgtgggatgatatttcatatgttcttccggaacacatgagc
atgtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (12)   
   OC (1)   
Protein sequence (7)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (27)   
   RefSeq(nuc) (5)   
   GenBank (11)   
   EMBL (11)   
3D Structure (35)   
   PDB (35)   
Protein domain (6)   
   Pfam (6)   
All databases (127)   

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