KEGG   Homo sapiens (human): 4734
Entry
4734              CDS       T01001                                 
Symbol
NEDD4, NEDD4-1, RPF1
Name
(RefSeq) NEDD4 E3 ubiquitin protein ligase
  KO
K10591  E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
hsa04144  Endocytosis
hsa04530  Tight junction
hsa05169  Epstein-Barr virus infection
Network
nt06165  Epstein-Barr virus (EBV)
nt06537  TCR/BCR signaling
  Element
N00488  EBV LMP2A to BCR signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    4734 (NEDD4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    4734 (NEDD4)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    4734 (NEDD4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    4734 (NEDD4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4734 (NEDD4)
   04121 Ubiquitin system [BR:hsa04121]
    4734 (NEDD4)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4734 (NEDD4)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     4734 (NEDD4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    4734 (NEDD4)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   4734 (NEDD4)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Morphogenesis factors
    4734 (NEDD4)
SSDB
Motif
Pfam: HECT WW
Other DBs
NCBI-GeneID: 4734
NCBI-ProteinID: NP_001271267
OMIM: 602278
HGNC: 7727
Ensembl: ENSG00000069869
UniProt: P46934
Structure
Position
15:complement(55826917..55993612)
AA seq 1319 aa
MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAP
LIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD
GIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGS
YTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDD
LEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFI
ISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNT
PRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTS
ACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGG
PSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLE
RPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAA
CHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQ
RAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEEL
NARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDER
GRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQG
FLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEE
RTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPN
KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF
NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY
KMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSE
IVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG
DVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAEL
YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD
NT seq 3960 nt   +upstreamnt  +downstreamnt
atggcacaaagcttacgattgcactttgcagccagaagaagcaatacttaccctttgtca
gaaacctccggagatgacttggatagccatgttcacatgtgcttcaaaagaccaacacgg
atttcaacgtctaacgttgttcaaatgaagctgactcccagacagactgcactagctccg
ttaataaaggaaaacgttcagtctcaagaaagatcatctgttccctcatctgaaaatgtt
aataaaaagagcagctgtctacagatttcactacagccaacaaggtacagtggatatctt
cagtctagcaatgtcttagctgatagtgatgatgcttcgtttacttgtatcttgaaggat
ggtatttacagtagtgctgtggtcgataatgaattgaatgctgtgaatgatggtcacctt
gtaagcagtccagccatttgtagtggtagccttagtaacttttcaaccagtgataatggg
tcttacagcagcaacggtagtgattttgggtcatgtgcaagtatcacaagtggaggttca
tatactaacagtgtcatcagtgacagtagtagttatacttttccaccaagtgatgatact
tttttgggtggaaacttaccttctgacagcacctccaatagaagtgtgccaaacaggaat
actactccttgtgaaattttttcaagaagtacaagtacagatccttttgtccaggatgac
ttggaacatggattagagattatgaaattgccagtgagcaggaacacaaaaattccacta
aaacgttactcctccttagtcatttttcctaggagtccttcaactacccgaccgacttct
ccaacaagtctgtgtactcttctgagcaaaggatcctatcaaacttcacaccagtttatt
atttctcctagtgaaattgcacataatgaggatggcactagtgctaaaggatttctttca
acagctgtcaatggacttcggttatctaaaacaatttgtacccccggagaagtaagagac
atacggccgcttcacaggaagggctcgttacagaagaaaattgttctttcgaataatact
cccagacagactgtctgtgaaaagtcatctgaaggatattcttgtgtttcagtgcatttc
acccaacgaaaagcagctacattagactgtgaaacaacaaatggtgattgtaaaccagaa
atgtcagaaattaagcttaattctgattcagagtatattaagctcatgcataggacatct
gcatgtttgccatcctcccaaaatgtagattgtcaaataaatatcaatggagaattggaa
agaccacattcacagatgaacaaaaaccatggtattttacgaagaagtatttcattggga
ggagcttatccaaatatttcctgtctatccagccttaagcacaattgttctaaaggggga
ccatctcagttactcataaagtttgcatctggaaatgaaggtaaagtggataatttatca
agagacagcaacagagattgcacaaatgaactgtctaattcttgcaagacaagagatgat
ttcctaggtcaagtggatgttccactttatccattaccgacagaaaatccaagattggag
agaccatatacatttaaggattttgttcttcatccaagaagtcacaaatcaagagttaaa
ggttatctgagactaaaaatgacttatttacctaaaaccagtggctcagaagatgataat
gcagaacaggctgaggaattagagcctggctgggttgttttggaccaaccagatgctgct
tgccatttgcagcaacaacaagaaccttctcctctacctccagggtgggaagagaggcag
gatatccttggaaggacctattatgtaaaccatgaatctagaagaacacagtggaaaaga
ccaacccctcaggacaacctaacagatgctgagaatggcaacattcaactgcaagcacaa
cgtgcatttaccaccaggcggcagatatccgaggaaacagaaagtgttgacaaccgagag
tcttccgagaactgggaaattataagagaagatgaagccaccatgtatagcaaccaggcc
ttcccatcacctccaccgtcaagtaacttggatgttccaactcatcttgcagaagaattg
aatgccagactcaccatttttggaaattcagccgtgagccagccagcatcgagctcaaat
cattccagcagaagaggcagcttacaagcctatacttttgaggaacaacctacacttcct
gtgcttttgcctacttcatctggattaccaccaggttgggaagaaaaacaagatgaaaga
ggaagatcatattatgtagatcacaattccagaacgactacttggacaaagcccactgta
caggccacagtggagaccagtcagctgacctcaagccagagttctgcaggccctcaatca
caagcctccaccagtgattcaggccagcaggtgacccagccatctgaaattgagcaagga
ttccttcctaaaggctgggaagtccggcatgcaccaaatgggaggcctttctttattgac
cacaacactaaaaccaccacctgggaagatccaagattgaaaattccagcccatctgaga
ggaaagacatcacttgatacttccaatgatctagggcctttacctccaggatgggaagag
agaactcacacagatggaagaatcttctacataaatcacaatataaaaagaacacaatgg
gaagatcctcggttggagaatgtagcaataactggaccagcagtgccctactccagggat
tacaaaagaaagtatgagttcttccgaagaaagttgaagaagcagaatgacattccaaac
aaatttgaaatgaaacttcgccgagcaactgttcttgaagactcttaccggagaattatg
ggtgtcaagagagcagacttcctgaaggctcgactgtggattgagtttgatggtgaaaag
ggattggattatggaggagttgccagagaatggttcttcctgatctcaaaggaaatgttt
aacccttattatgggttgtttgaatattctgctacggacaattataccctacagataaat
ccaaactctggattgtgtaacgaagatcacctctcttacttcaagtttattggtcgggta
gctggaatggcagtttatcatggcaaactgttggatggttttttcatccgcccattttac
aagatgatgcttcacaaaccaataacccttcatgatatggaatctgtggatagtgaatat
tacaattccctaagatggattcttgaaaatgacccaacagaattggacctcaggtttatc
atagatgaagaactttttggacagacacatcaacatgagctgaaaaatggtggatcagaa
atagttgtcaccaataagaacaaaaaggaatatatttatcttgtaatacaatggcgattt
gtaaaccgaatccagaagcaaatggctgcttttaaagagggattctttgaactaatacca
caggatctcatcaaaatttttgatgaaaatgaactagagcttcttatgtgtggactggga
gatgttgatgtgaatgactggagggaacatacaaagtataaaaatggctacagtgcaaat
catcaggttatacagtggttttggaaggctgttttaatgatggattcagaaaaaagaata
agattacttcagtttgtcactggcacatctcgggtgcctatgaatggatttgctgaacta
tacggttcaaatggaccacagtcatttacagttgaacagtggggtactcctgaaaagctg
ccaagagctcatacctgttttaatcgcctggacttgccaccttatgaatcatttgaagaa
ttatgggataaacttcagatggcaattgaaaacacccagggctttgatggagttgattag

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (4)   
   KEGG PATHWAY (4)   
Network (3)   
   KEGG NETWORK (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (14)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (12)   
DNA sequence (45)   
   RefSeq(nuc) (13)   
   GenBank (16)   
   EMBL (16)   
3D Structure (13)   
   PDB (13)   
Protein domain (2)   
   Pfam (2)   
All databases (114)   

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