KEGG   Homo sapiens (human): 48
Entry
48                CDS       T01001                                 
Symbol
ACO1, ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
Name
(RefSeq) aconitase 1
  KO
K01681  aconitate hydratase [EC:4.2.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00020  Citrate cycle (TCA cycle)
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa01210  2-Oxocarboxylic acid metabolism
hsa01230  Biosynthesis of amino acids
Module
hsa_M00009  Citrate cycle (TCA cycle, Krebs cycle)
hsa_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Network
nt06031  Citrate cycle and pyruvate metabolism
  Element
N01604  Citrate cycle, first carbon oxidation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    48 (ACO1)
   00630 Glyoxylate and dicarboxylate metabolism
    48 (ACO1)
Enzymes [BR:hsa01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.3  aconitate hydratase
     48 (ACO1)
SSDB
Motif
Pfam: Aconitase Aconitase_C
Other DBs
NCBI-GeneID: 48
NCBI-ProteinID: NP_001265281
OMIM: 100880
HGNC: 117
Ensembl: ENSG00000122729
UniProt: P21399 V9HWB7 Q9HBB2
Structure
Position
9:32384643..32454769
AA seq 889 aa
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDI
ENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPA
DLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQV
NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLP
QVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC
PEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVE
LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNT
EFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTY
YLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEG
RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE
RQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPK
SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMA
RGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSR
DWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIP
ENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
NT seq 2670 nt   +upstreamnt  +downstreamnt
atgagcaacccattcgcacaccttgctgagccattggatcctgtacaaccaggaaagaaa
ttcttcaatttgaataaattggaggattcaagatatgggcgcttaccattttcgatcaga
gttcttctggaagcagccattcggaattgtgatgagtttttggtgaagaaacaggatatt
gaaaatattctacattggaatgtcacgcagcacaagaacatagaagtgccatttaagcct
gctcgtgtcatcctgcaggactttacgggtgtgcccgctgtggttgactttgctgcaatg
cgtgatgctgtgaaaaagttaggaggagatccagagaaaataaaccctgtctgccctgct
gatcttgtaatagatcattccatccaggttgatttcaacagaagggcagacagtttacag
aagaatcaagacctggaatttgaaagaaatagagagcgatttgaatttttaaagtggggt
tcccaggcttttcacaacatgcggattattccccctggctcaggaatcatccaccaggtg
aatttggaatatttggcaagagtggtatttgatcaggatggatattattacccagacagc
ctcgtgggcacagactcgcacactaccatgattgatggcttgggcattcttggttggggt
gtcggtggtattgaagcagaagctgtcatgctgggtcagccaatcagtatggtgcttcct
caggtgattggctacaggctgatggggaagccccaccctctggtaacatccactgacatc
gtgctcaccattaccaagcacctccgccaggttggggtagtgggcaaatttgtcgagttc
ttcgggcctggagtagcccagttgtccattgctgaccgagctacgattgctaacatgtgt
ccagagtacggagcaactgctgcctttttcccagttgatgaagttagtatcacgtacctg
gtgcaaacaggtcgtgatgaagaaaaattaaagtatattaaaaaatatcttcaggctgta
ggaatgtttcgagatttcaatgacccttctcaagacccagacttcacccaggttgtggaa
ttagatttgaaaacagtagtgccttgctgtagtggacccaaaaggcctcaggacaaagtt
gctgtgtccgacatgaaaaaggactttgagagctgccttggagccaagcaaggatttaaa
ggattccaagttgctcctgaacatcataatgaccataagacctttatctatgataacact
gaattcacccttgctcatggttctgtggtcattgctgccattactagctgcacaaacacc
agtaatccgtctgtgatgttaggggcaggattgttagcaaagaaagctgtggatgctggc
ctgaacgtgatgccttacatcaaaactagcctgtctcctgggagtggcgtggtcacctac
tacctacaagaaagcggagtcatgccttatctgtctcagcttgggtttgacgtggtgggc
tatggctgcatgacctgcattggcaacagtgggcctttacctgaacctgtggtagaagcc
atcacacagggagaccttgtagctgttggagtactatctggaaacaggaattttgaaggt
cgagttcaccccaacacccgggccaactatttagcctctccccccttagtaatagcatat
gcaattgctggaaccatcagaatcgactttgagaaagagccattgggagtaaatgcaaag
ggacagcaggtatttctgaaagatatctggccgactagagacgagatccaggcagtggag
cgtcagtatgtcatcccggggatgtttaaggaagtctatcagaaaatagagactgtgaat
gaaagctggaatgccttagcaaccccatcagataagctgtttttctggaattccaaatct
acgtatatcaaatcaccaccattctttgaaaacctgactttggatcttcagccccctaaa
tctatagtggatgcctatgtgctgctaaatttgggagattcggtaacaactgaccacatc
tccccagctggaaatattgcaagaaacagtcctgctgctcgctacttaactaacagaggc
ctaactccacgagaattcaactcctatggctcccgccgaggtaatgacgccgtcatggca
cggggaacatttgccaacattcgcttgttaaacagatttttgaacaagcaggcaccacag
actatccatctgccttctggggaaatccttgatgtgtttgatgctgctgagcggtaccag
caggcaggccttcccctgatcgttctggctggcaaagagtacggtgcaggcagctcccga
gactgggcagctaagggccctttcctgctgggaatcaaagccgtcctggccgagagctac
gagcgcattcaccgcagtaacctggttgggatgggtgtgatcccacttgaatatctccct
ggtgagaatgcagatgccctggggctcacagggcaagaacgatacactatcattattcca
gaaaacctcaaaccacaaatgaaagtccaggtcaagctggatactggcaagaccttccag
gctgtcatgaggtttgacactgatgtggagctcacttatttcctcaacgggggcatcctc
aactacatgatccgcaagatggccaagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (11)   
   KEGG PATHWAY (6)   
   KEGG MODULE (5)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (10)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (34)   
   RefSeq(nuc) (6)   
   GenBank (14)   
   EMBL (14)   
3D Structure (2)   
   PDB (2)   
Protein domain (2)   
   Pfam (2)   
All databases (84)   

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