| Entry |
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| Symbol |
NPR2, AMD1, AMDM, ANPRB, ANPb, ECDM, GC-B, GCB, GUC2B, GUCY2B, NPRB, NPRBi, SNSK
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| Name |
(RefSeq) natriuretic peptide receptor 2
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| KO |
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| Organism |
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| Pathway |
| hsa04270 | Vascular smooth muscle contraction |
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| Network |
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| Element |
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| Disease |
| H00470 | Acromesomelic dysplasia, Maroteaux type |
| H02543 | Acromesomelic dysplasia |
| H02679 | Miura-type epiphyseal chondrodysplasia |
| H02681 | Short stature with nonspecific skeletal abnormalities |
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| Drug target |
| Eritrityl tetranitrate: | D04051 |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
4882 (NPR2)
09130 Environmental Information Processing
09132 Signal transduction
04022 cGMP-PKG signaling pathway
4882 (NPR2)
09150 Organismal Systems
09152 Endocrine system
04921 Oxytocin signaling pathway
4882 (NPR2)
09153 Circulatory system
04270 Vascular smooth muscle contraction
4882 (NPR2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:hsa01001]
4882 (NPR2)
Enzymes [BR:hsa01000]
4. Lyases
4.6 Phosphorus-oxygen lyases
4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date)
4.6.1.2 guanylate cyclase
4882 (NPR2)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: Other
RGC family [OT]
4882 (NPR2)
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| SSDB |
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| Motif |
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| Other DBs |
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| Position |
9:35791591..35809731
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| AA seq |
1047 aa
MALPSLLLLVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRAL
PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLL
TAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH
YFTIEGVFEALQGSNLSVQHQVYAREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQA
QRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTREQAQALREAFQTVLVITYRE
PPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTRED
GLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWW
TGRPIPWVKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRK
LMLEKELASMLWRIRWEELQFGNSERYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANT
GHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCP
RGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKI
TDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALR
SGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPAERPDFG
QIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPH
SVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNF
DVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV
HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR
GDVEMKGKGKMRTYWLLGERKGPPGLL |
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| NT seq |
3144 nt +upstreamnt +downstreamnt
atggcgctgccatcacttctgctgttggtggcagccctggcaggtggggtgcgtcctccc
ggggcgcggaacctgacgctggcggtggtgctgccagaacacaacctgagctatgcctgg
gcctggccacgggtgggacccgctgtggcactagctgtggaggctctgggccgggcactg
cccgtggacctgcggtttgtcagctccgaactggaaggcgcctgctctgagtacctggca
ccgctgagcgctgtggacctcaagctgtaccatgaccccgacctgctgttaggtcccggt
tgcgtgtaccctgctgcctctgtggcccgctttgcctcccactggcgccttcccctgctg
actgcgggtgctgtggcctctggtttttcggctaagaatgaccattatcgtaccctggtt
cgcactggcccctctgctcccaagctgggtgagtttgtggtgacactacacgggcacttc
aattggactgcccgtgctgccttgctgtacctggatgctcgcacagatgaccggcctcac
tacttcaccatcgagggcgtctttgaggccctgcagggcagcaacctcagtgtgcagcac
caggtgtatgcccgagagccagggggccccgagcaggccacccacttcatccgggccaac
gggcgcattgtgtatatctgcggccctctggagatgctgcatgagatcctgcttcaggcc
cagagggagaatctgaccaatggggattatgtcttcttttacctggatgtctttggggag
agtctccgtgcaggccccacacgtgctacaggccggccctggcaggacaatcgcacccgg
gaacaggcccaggccctcagagaggcctttcagactgtattggtgatcacgtaccgagaa
cccccaaatcctgagtatcaggaattccagaatcgtctgctgataagagcccgggaagac
tttggtgtggagctgggcccttccctgatgaacctcatcgctggctgcttctatgatggg
atcctgctatatgctgaagtcctgaatgagacaatacaggaaggaggcacccgggaggat
ggacttcgaattgtggaaaagatgcagggacgaagatatcacggtgtaactgggctggtt
gtcatggacaagaacaatgaccgagagactgactttgtcctctgggccatgggagacctg
gattctggggactttcagcctgcagcccactactcgggagctgagaagcagatttggtgg
acgggacggcctattccctgggtgaagggggctcctccctcggacaatcccccctgtgcc
tttgacttggacgacccatcctgtgataaaactccactttcaaccctggcaattgtggct
ctgggcacaggaatcaccttcatcatgtttggtgtttccagcttcctaattttccgaaag
ctgatgctggagaaggagctggctagcatgttgtggcgtattcgctgggaagaactgcag
tttggcaactcagagcgttatcacaaaggtgcaggcagtcgcctcacactgtcgctgcgg
ggatccagttacggctcgctcatgacagcccatgggaaataccagatctttgccaacacc
ggtcacttcaagggaaatgttgtcgccatcaaacatgtgaataagaagcgcattgagctg
acccggcaggttctgtttgaactcaaacatatgagagatgttcagttcaaccatctcact
cgcttcattggcgcctgcatagaccctcccaacatttgcattgtcactgaatactgtcct
cgtgggagtttacaggatattctagaaaatgacagcatcaacttggactggatgtttcgt
tattcactcattaatgaccttgttaagggcatggcctttctccacaacagcattatttca
tcgcatgggagtctcaagtcctccaactgtgtggtggatagtcgttttgtgctcaaaatc
acagactatggcctggccagcttccgatcaactgctgaacctgatgacagccatgccctc
tatgccaagaagctgtggactgccccagaactgctcagtgggaaccccttgccaaccaca
ggcatgcagaaggctgacgtctatagctttgggatcatcctgcaggagatagcacttcgc
agtggtcctttctacttggagggcctggacctcagccccaaagagattgtccagaaggta
cgaaatggtcagcggccatatttccggccaagcattgaccggacccaactgaatgaagag
ctagttttgctgatggagcgatgttgggctcaggacccagctgagcggccagactttgga
cagattaagggcttcattcggcgctttaacaaggagggtggcaccagcatattggacaac
ctcctgctgcgcatggaacagtatgccaataacttggagaagctggtggaggaacgcaca
caggcctatctggaggaaaaacgcaaggctgaagctctgctctaccaaatcctaccccat
tcagtggcagagcagttaaaacggggagagactgtacaggctgaggcctttgacagtgtt
accatctacttcagtgacattgttggcttcacagcattgtcagcagagagcacccccatg
caggtagtgacacttcttaatgacctgtatacctgctttgatgccataattgacaacttt
gatgtctacaaggtggagacgattggggatgcttacatggtggtatctggcctcccaggc
cgaaatggtcaacgccatgcaccagaaattgctcgtatggccctagcattactagatgca
gtttcttcctttcgcatccgccaccgaccccatgaccagctgaggctacgcataggggtc
catactgggccagtctgtgctggggttgttggcctgaagatgccccgttattgtcttttt
ggagacacagtgaacactgcttctcgaatggagtctaatggtcaagcgctgaagatccat
gtctcctctaccaccaaggatgccctagatgagctaggatgcttccagctagagcttcgg
ggggatgtggaaatgaagggaaaaggaaagatgcgaacatactggctcttaggagagcgg
aaaggacctcctggactcctgtaa |
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