KEGG T01001: 4986

Homo sapiens (human): 4986

Entry

4986              CDS       T01001

Symbol

OPRK1, K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK

Name

(RefSeq) opioid receptor kappa 1

K04214

kappa-type opioid receptor

Organism

hsa Homo sapiens (human)

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Drug target

Acetorphine:

D12700

Aticaprant:

D11831

Buprenorphine (DG00820):

D00836<JP/US> D07132<JP/US>

Butorphanol (DG00821):

D00837<US> D03197

Cyclazocine:

D03618

Dezocine:

D00838

Difelikefalin (DG02914):

D10890<JP/US> D11111

Diprenorphine (DG01273):

D07863 D07864

Eluxadoline:

D10403<US>

Enadoline hydrochloride:

D06395

Eptazocine (DG01340):

D01879 D07904

Etorphine:

D07937

Ketazocine:

D04649

Ketobemidone (DG00815):

D08100 D08101

Levallorphan tartrate:

D02238<JP>

Loperamide (DG00092):

D00729<JP/US> D08144

Loperamide oxide (DG00092):

D07113

Nalbuphine (DG00822):

D00843<US> D08246

Nalfurafine:

D06405<JP>

Nalmefene (DG00998):

D02104<US> D05111 D10812<JP>

Nalorphine (DG01151):

D08247 D08248

Naloxone (DG01155):

D01340<JP/US> D08249 D11620<US>

Naltrexone (DG00997):

D02095<US> D05113<US>

Navacaprant (DG03305):

D12869 D12870

Oxilorphan:

D05299

Oxycodone (DG00813):

D00847<US> D03783 D05312<US> D05462<JP>

Pentazocine (DG00819):

D00498<JP> D02111 D02227<JP>

Proxorphan tartrate:

D05646

Quadazocine mesylate:

D05667

Spiradoline mesylate:

D05907

Tonazocine mesylate:

D06189

Trimebutine (DG00031):

D01500<JP> D08639

Xorphanol mesylate:

D06342

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    4986 (OPRK1)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    4986 (OPRK1)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Peptide
   Opioid
    4986 (OPRK1)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srv 7TM_GPCR_Srx V1R

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

8:complement(53225724..53251637)

AA seq 380 aa
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV

NT seq 1143 nt +upstreamnt +downstreamnt
atggactccccgatccagatcttccgcggggagccgggccctacctgcgccccgagcgcc
tgcctgccccccaacagcagcgcctggtttcccggctgggccgagcccgacagcaacggc
agcgccggctcggaggacgcgcagctggagcccgcgcacatctccccggccatcccggtc
atcatcacggcggtctactccgtagtgttcgtcgtgggcttggtgggcaactcgctggtc
atgttcgtgatcatccgatacacaaagatgaagacagcaaccaacatttacatatttaac
ctggctttggcagatgctttagttactacaaccatgccctttcagagtacggtctacttg
atgaattcctggccttttggggatgtgctgtgcaagatagtaatttccattgattactac
aacatgttcaccagcatcttcaccttgaccatgatgagcgtggaccgctacattgccgtg
tgccaccccgtgaaggctttggacttccgcacacccttgaaggcaaagatcatcaatatc
tgcatctggctgctgtcgtcatctgttggcatctctgcaatagtccttggaggcaccaaa
gtcagggaagacgtcgatgtcattgagtgctccttgcagttcccagatgatgactactcc
tggtgggacctcttcatgaagatctgcgtcttcatctttgccttcgtgatccctgtcctc
atcatcatcgtctgctacaccctgatgatcctgcgtctcaagagcgtccggctcctttct
ggctcccgagagaaagatcgcaacctgcgtaggatcaccagactggtcctggtggtggtg
gcagtcttcgtcgtctgctggactcccattcacatattcatcctggtggaggctctgggg
agcacctcccacagcacagctgctctctccagctattacttctgcatcgccttaggctat
accaacagtagcctgaatcccattctctacgcctttcttgatgaaaacttcaagcggtgt
ttccgggacttctgctttccactgaagatgaggatggagcggcagagcactagcagagtc
cgaaatacagttcaggatcctgcttacctgagggacatcgatgggatgaataaaccagta
tga

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