KEGG   Homo sapiens (human): 501
Entry
501               CDS       T01001                                 
Symbol
ALDH7A1, ATQ1, EPD, EPEO4, PDE
Name
(RefSeq) aldehyde dehydrogenase 7 family member A1
  KO
K14085  aldehyde dehydrogenase family 7 member A1 [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00053  Ascorbate and aldarate metabolism
hsa00071  Fatty acid degradation
hsa00260  Glycine, serine and threonine metabolism
hsa00280  Valine, leucine and isoleucine degradation
hsa00310  Lysine degradation
hsa00330  Arginine and proline metabolism
hsa00340  Histidine metabolism
hsa00380  Tryptophan metabolism
hsa00410  beta-Alanine metabolism
hsa00561  Glycerolipid metabolism
hsa00620  Pyruvate metabolism
hsa01100  Metabolic pathways
hsa04936  Alcoholic liver disease
Module
hsa_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
hsa_M00135  GABA biosynthesis, eukaryotes, putrescine => GABA
hsa_M00555  Betaine biosynthesis, choline => betaine
Network
nt06036  Lysine degradation
  Element
N01685  Lysine degradation 1
Disease
H01247  Pyridoxine-dependent epilepsy
H02696  Early-onset epilepsy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    501 (ALDH7A1)
   00053 Ascorbate and aldarate metabolism
    501 (ALDH7A1)
   00620 Pyruvate metabolism
    501 (ALDH7A1)
  09103 Lipid metabolism
   00071 Fatty acid degradation
    501 (ALDH7A1)
   00561 Glycerolipid metabolism
    501 (ALDH7A1)
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    501 (ALDH7A1)
   00280 Valine, leucine and isoleucine degradation
    501 (ALDH7A1)
   00310 Lysine degradation
    501 (ALDH7A1)
   00330 Arginine and proline metabolism
    501 (ALDH7A1)
   00340 Histidine metabolism
    501 (ALDH7A1)
   00380 Tryptophan metabolism
    501 (ALDH7A1)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    501 (ALDH7A1)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    501 (ALDH7A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.3  aldehyde dehydrogenase (NAD+)
     501 (ALDH7A1)
    1.2.1.8  betaine-aldehyde dehydrogenase
     501 (ALDH7A1)
    1.2.1.31  L-aminoadipate-semialdehyde dehydrogenase
     501 (ALDH7A1)
SSDB
Motif
Pfam: Aldedh
Other DBs
NCBI-GeneID: 501
NCBI-ProteinID: NP_001173
OMIM: 107323
HGNC: 877
Ensembl: ENSG00000164904
UniProt: P49419
Structure
Position
5:complement(126541841..126595219)
AA seq 539 aa
MWRLPRALCVHAAKTSKLSGPWSRPAAFMSTLLINQPQYAWLKELGLREENEGVYNGSWG
GRGEVITTYCPANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDA
LREKIQVLGSLVSLEMGKILVEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIE
QWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLED
NKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGN
NAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVG
NPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHD
ASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGI
VNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
NT seq 1620 nt   +upstreamnt  +downstreamnt
atgtggcgccttcctcgcgcgctgtgtgtgcacgctgcaaagaccagcaagctctctgga
ccttggagcaggcctgccgccttcatgtccactctcctcatcaatcagccccagtatgcg
tggctgaaagagctggggctccgcgaggaaaacgagggcgtgtataatggaagctgggga
ggccggggagaggttattacgacctattgccctgctaacaacgagccaatagcaagagtc
cgacaggccagtgtggcagactatgaagaaactgtaaagaaagcaagagaagcatggaaa
atctgggcagatattcctgctccaaaacgaggagaaatagtaagacagattggcgatgcc
ttgcgggagaagatccaagtactaggaagcttggtgtctttggagatggggaaaatctta
gtggaaggtgtgggtgaagttcaggagtatgtggatatctgtgactatgctgttggttta
tcaaggatgattggaggacctatcttgccttctgaaagatctggccatgcactgattgag
cagtggaatcccgtaggcctggttggaatcatcacggcattcaatttccctgtggcagtg
tatggttggaacaacgccatcgccatgatctgtggaaatgtctgcctctggaaaggagct
ccaaccacttccctcattagtgtggctgtcacaaagataatagccaaggttctggaggac
aacaagctgcctggtgcaatttgttccttgacttgtggtggagcagatattggcacagca
atggccaaagatgaacgagtgaacctgctgtccttcactgggagcactcaggtgggaaaa
caggtgggcctgatggtgcaggagaggtttgggagaagtctgttggaacttggaggaaac
aatgccattattgcctttgaagatgcagacctcagcttagttgttccatcagctctcttc
gctgctgtgggaacagctggccagaggtgtaccactgcgaggcgactgtttatacatgaa
agcatccatgatgaggttgtaaacagacttaaaaaggcctatgcacagatccgagttggg
aacccatgggaccctaatgttctctatgggccactccacaccaagcaggcagtgagcatg
tttcttggagcagtggaagaagcaaagaaagaaggtggcacagtggtctatgggggcaag
gttatggatcgccctggaaattatgtagaaccgacaattgtgacaggtcttggccacgat
gcgtccattgcacacacagagacttttgctccgattctctatgtctttaaattcaagaat
gaagaagaggtctttgcatggaataatgaagtaaaacagggactttcaagtagcatcttt
accaaagatctgggcagaatctttcgctggcttggacctaaaggatcagactgtggcatt
gtaaatgtcaacattccaacaagtggggctgagattggaggtgcctttggaggagaaaag
cacactggtggtggcagggagtctggcagtgatgcctggaaacagtacatgagaaggtct
acttgtactatcaactacagtaaagaccttcctctggcccaaggaatcaagtttcagtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (17)   
   KEGG PATHWAY (14)   
   KEGG MODULE (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (38)   
   KEGG COMPOUND (38)   
Chemical reaction (22)   
   KEGG ENZYME (3)   
   KEGG REACTION (19)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (39)   
   RefSeq(nuc) (3)   
   GenBank (18)   
   EMBL (18)   
3D Structure (20)   
   PDB (20)   
Protein domain (1)   
   Pfam (1)   
All databases (172)   

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