KEGG   Homo sapiens (human): 5033
Entry
5033              CDS       T01001                                 
Symbol
P4HA1, P4HA
Name
(RefSeq) prolyl 4-hydroxylase subunit alpha 1
  KO
K00472  prolyl 4-hydroxylase [EC:1.14.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00330  Arginine and proline metabolism
hsa01100  Metabolic pathways
Drug target
Lufironil: D04793
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00330 Arginine and proline metabolism
    5033 (P4HA1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.2  procollagen-proline 4-dioxygenase
     5033 (P4HA1)
SSDB
Motif
Pfam: P4Ha_N 2OG-FeII_Oxy_3 2OG-FeII_Oxy TPR_2 Fis1_TPR_C TPR_19 TPR_1 TPR_14
Other DBs
NCBI-GeneID: 5033
NCBI-ProteinID: NP_000908
OMIM: 176710
HGNC: 8546
Ensembl: ENSG00000122884
UniProt: P13674 Q5VSQ6
Structure
Position
10:complement(73007217..73096866)
AA seq 534 aa
MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWA
EKLDRLTSTATKDPEGFVGHPVNAFKLMKRLNTEWSELENLVLKDMSDGFISNLTIQRQY
FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPGVKHKSFLTAEDCFELGKVAYTEADY
YHTELWMEQALRQLDEGEISTIDKVSVLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQR
ANGNLKYFEYIMAKEKDVNKSASDDQSDQKTTPKKKGVAVDYLPERQKYEMLCRGEGIKM
TPRRQKKLFCRYHDGNRNPKFILAPAKQEDEWDKPRIIRFHDIISDAEIEIVKDLAKPRL
SRATVHDPETGKLTTAQYRVSKSAWLSGYENPVVSRINMRIQDLTGLDVSTAEELQVANY
GVGGQYEPHFDFARKDEPDAFKELGTGNRIATWLFYMSDVSAGGATVFPEVGASVWPKKG
TAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHERGQEFRRPCTLSELE
NT seq 1605 nt   +upstreamnt  +downstreamnt
atgatctggtatatattaattataggaattctgcttccccagtctttggctcatccaggc
ttttttacttcaattggtcagatgactgatttgatccatactgagaaagatctggtgact
tctctgaaagattatattaaggcagaagaggacaagttagaacaaataaaaaaatgggca
gagaagttagatcggctaactagtacagcgacaaaagatccagaaggatttgttgggcat
ccagtaaatgcattcaaattaatgaaacgtctgaatactgagtggagtgagttggagaat
ctggtccttaaggatatgtcagatggctttatctctaacctaaccattcagagacagtac
tttcctaatgatgaagatcaggttggggcagccaaagctctgttacgtctccaggatacc
tacaatttggatacagataccatctcaaagggtaatcttccaggagtgaaacacaaatct
tttctaacggctgaggactgctttgagttgggcaaagtggcctatacagaagcagattat
taccatacggaactgtggatggaacaagccctaaggcaactggatgaaggcgagatttct
accatagataaagtctctgttctagattatttgagctatgcggtatatcagcagggagac
ctggataaggcacttttgctcacaaagaagcttcttgaactagatcctgaacatcagaga
gctaatggtaacttaaaatattttgagtatataatggctaaagaaaaagatgtcaataag
tctgcttcagatgaccaatctgatcagaaaactacaccaaagaaaaaaggggttgctgtg
gattacctgccagagagacagaagtacgaaatgctgtgccgtggggagggtatcaaaatg
acccctcggagacagaaaaaactcttttgccgctaccatgatggaaaccgtaatcctaaa
tttattctggctccagctaaacaggaggatgaatgggacaagcctcgtattattcgcttc
catgatattatttctgatgcagaaattgaaatcgtcaaagacctagcaaaaccaaggctg
agccgagctacagtacatgaccctgagactggaaaattgaccacagcacagtacagagta
tctaagagtgcctggctctctggctatgaaaatcctgtggtgtctcgaattaatatgaga
atacaagatctaacaggactagatgtttccacagcagaggaattacaggtagcaaattat
ggagttggaggacagtatgaaccccattttgactttgcacggaaagatgagccagatgct
ttcaaagagctggggacaggaaatagaattgctacatggctgttttatatgagtgatgtg
tctgcaggaggagccactgtttttcctgaagttggagctagtgtttggcccaaaaaagga
actgctgttttctggtataatctgtttgccagtggagaaggagattatagtacacggcat
gcagcctgtccagtgctagttggcaacaaatgggtatccaataaatggctccatgaacgt
ggacaagaatttcgaagaccttgtacgttgtcagaattggaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
3D Structure (7)   
   PDB (7)   
Protein domain (8)   
   Pfam (8)   
All databases (78)   

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