KEGG   Homo sapiens (human): 50649
Entry
50649             CDS       T01001                                 
Symbol
ARHGEF4, ASEF, ASEF1, GEF4, SMIM39, STM6
Name
(RefSeq) Rho guanine nucleotide exchange factor 4
  KO
K05769  Rho guanine nucleotide exchange factor 4/29
Organism
hsa  Homo sapiens (human)
Pathway
hsa04810  Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    50649 (ARHGEF4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    50649 (ARHGEF4)
Membrane trafficking [BR:hsa04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    50649 (ARHGEF4)
SSDB
Motif
Pfam: RhoGEF SH3_1 PH SH3_2 SH3_9
Other DBs
NCBI-GeneID: 50649
NCBI-ProteinID: NP_056135
OMIM: 605216
HGNC: 684
Ensembl: ENSG00000136002
UniProt: Q9NR80 Q9NTG0
Structure
Position
2:130836914..131047253
AA seq 690 aa
MPWEEPAGEKPSCSHSQKAFHMEPAQKPCFTTDMVTWALLCISAETVRGEAPSQPRGIPH
RSPVSVDDLWLEKTQRKKLQKQAHVERRLHIGAVHKDGVKCWRKTIITSPESLNLPRRSH
PLSQSAPTGLNHMGWPEHTPGTAMPDGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGG
GGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGE
GWFPASFVRLRVNQDEPADDDAPLAGNSGAEDGGAEAQSSKDQMRTNVINEILSTERDYI
KHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSE
LGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQKMIDISLDGFL
LTPVQKICKYPLQLAELLKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQ
WQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKSQQRMFFLFDHQLIYCKKDLLRRDV
LYYKGRLDMDGLEVVDLEDGKDRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKA
FAREREQVQLDQETGFSITELQRKQAMLNASKQQVTGKPKAVGRPCYLTRQKHPALPSNR
PQQQVLVLAEPRRKPSTFWHSISRLAPFRK
NT seq 2073 nt   +upstreamnt  +downstreamnt
atgccctgggaagaaccagcaggtgagaagcccagttgctctcacagtcagaaggcgttc
cacatggagcctgcccagaagccctgcttcaccactgacatggtgacatgggccctcctc
tgcatctctgcagagactgtgcgtggggaggctccttcacagcctaggggcatccctcac
cgctcgcccgtcagtgtggatgacctgtggctggagaagacacagagaaagaagttgcag
aagcaggcccacgtcgaaaggaggctgcacataggggcagtgcacaaagatggagtcaag
tgctggagaaagacgatcattacctctccagagtctttgaatctccctagaagaagccat
ccactctcccagagtgctccaacgggactgaaccacatgggctggccagagcacacacca
ggcactgccatgcctgatggagctctggacacagctgtctgcgctgacgaagtggggagc
gaggaggacctgtatgatgacctgcacagctccagccaccactacagccaccctggaggg
ggtggggagcagctggctatcaatgagctcatcagcgatggcagtgtggtctgcgctgaa
gcactctgggaccatgtcaccatggacgaccaggagctgggcttcaaagctggggacgtc
atcgaagtgatggatgccaccaacagagagtggtggtggggccgggtcgccgatggcgag
ggctggtttccagccagcttcgttcggctgagggtgaatcaggacgagcccgcggatgac
gacgcccctctggccgggaacagcggagcggaggacggcggggcggaggcgcagagcagc
aaggaccagatgcggaccaacgtcatcaacgagatcctcagcactgagcgggactacatc
aagcacctgcgcgacatctgcgagggctacgtccggcagtgccgcaagcgcgcagacatg
ttcagcgaggagcagctgcgtaccatcttcgggaacatcgaggacatctaccgctgccag
aaggccttcgtgaaggccctggagcagaggttcaaccgcgagcgcccacacctgagcgag
ctgggtgcctgcttcctggagcatcaagccgacttccagatctactcggagtactgcaat
aaccaccccaacgcctgcgtggagctctcccggctcaccaagctcagcaagtacgtgtac
ttcttcgaggcctgccggctgctgcagaagatgattgacatctccctggatggcttcctg
ctgactccggtgcagaagatctgcaagtaccctctgcagctggccgagctgctcaaatac
acgcacccccagcacagggacttcaaggatgttgaagccgccttgcatgccatgaagaac
gtggcccagctcatcaacgagcggaagcggagacttgagaacatcgacaagattgctcag
tggcagagctccatagaggactgggagggagaagatctcttggtcaggagctcagaactc
atctactcgggggagctgactcgagttacacagcctcaagccaaaagccagcagcgaatg
ttctttctctttgaccaccagctcatctactgtaagaaggacctgctccgccgcgacgtg
ttgtactacaagggccggctggacatggacggcctggaggtggtggacctggaggacggg
aaggacagagacctccatgtgagcatcaagaacgccttccggctgcaccgtggcgccaca
ggggacagccacctgctgtgcaccaggaagcccgagcagaagcagcgctggctcaaggcc
tttgccagggagagggagcaggtgcagctggaccaggagacaggcttctccatcactgaa
ctgcagaggaagcaggccatgctgaatgccagcaagcagcaggtcacagggaagcccaaa
gctgttggccggccctgctacctgacgcgccagaagcacccagccctgcccagcaaccgg
ccccagcagcaggtcctggtgctggcggagcccaggcgcaagccatctaccttctggcac
agcatcagccggctggcacccttccgcaagtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (25)   
   RefSeq(nuc) (9)   
   GenBank (8)   
   EMBL (8)   
3D Structure (4)   
   PDB (4)   
Protein domain (5)   
   Pfam (5)   
All databases (66)   

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