KEGG   Homo sapiens (human): 5069
Entry
5069              CDS       T01001                                 
Symbol
PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1
Name
(RefSeq) pappalysin 1
  KO
K07762  pappalysin-1 [EC:3.4.24.79]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5069 (PAPPA)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.79  pappalysin-1
     5069 (PAPPA)
Peptidases and inhibitors [BR:hsa01002]
 Metallo peptidases
  Family M43: cytophagalysin family
   5069 (PAPPA)
SSDB
Motif
Pfam: Sushi Laminin_G_3 Peptidase_M43 DUF4215 Notch Reprolysin_3 Peptidase_M10 Reprolysin_4 DUF4953
Other DBs
NCBI-GeneID: 5069
NCBI-ProteinID: NP_002572
OMIM: 176385
HGNC: 8602
Ensembl: ENSG00000182752
UniProt: Q13219 Q7Z613 B4DTA8
Structure
Position
9:116153791..116402321
AA seq 1627 aa
MRLWSWVLHLGLLSAALGCGLAERPRRARRDPRAGRPPRPAAGPATCATRAARGRRASPP
PPPPPGGAWEAVRVPRRRQQREARGATEEPSPPSRALYFSGRGEQLRLRADLELPRDAFT
LQVWLRAEGGQRSPAVITGLYDKCSYISRDRGWVVGIHTISDQDNKDPRYFFSLKTDRAR
QVTTINAHRSYLPGQWVYLAATYDGQFMKLYVNGAQVATSGEQVGGIFSPLTQKCKVLML
GGSALNHNYRGYIEHFSLWKVARTQREILSDMETHGAHTALPQLLLQENWDNVKHAWSPM
KDGSSPKVEFSNAHGFLLDTSLEPPLCGQTLCDNTEVIASYNQLSSFRQPKVVRYRVVNL
YEDDHKNPTVTREQVDFQHHQLAEAFKQYNISWELDVLEVSNSSLRRRLILANCDISKIG
DENCDPECNHTLTGHDGGDCRHLRHPAFVKKQHNGVCDMDCNYERFNFDGGECCDPEITN
VTQTCFDPDSPHRAYLDVNELKNILKLDGSTHLNIFFAKSSEEELAGVATWPWDKEALMH
LGGIVLNPSFYGMPGHTHTMIHEIGHSLGLYHVFRGISEIQSCSDPCMETEPSFETGDLC
NDTNPAPKHKSCGDPGPGNDTCGFHSFFNTPYNNFMSYADDDCTDSFTPNQVARMHCYLD
LVYQGWQPSRKPAPVALAPQVLGHTTDSVTLEWFPPIDGHFFERELGSACHLCLEGRILV
QYASNASSPMPCSPSGHWSPREAEGHPDVEQPCKSSVRTWSPNSAVNPHTVPPACPEPQG
CYLELEFLYPLVPESLTIWVTFVSTDWDSSGAVNDIKLLAVSGKNISLGPQNVFCDVPLT
IRLWDVGEEVYGIQIYTLDEHLEIDAAMLTSTADTPLCLQCKPLKYKVVRDPPLQMDVAS
ILHLNRKFVDMDLNLGSVYQYWVITISGTEESEPSPAVTYIHGSGYCGDGIIQKDQGEQC
DDMNKINGDGCSLFCRQEVSFNCIDEPSRCYFHDGDGVCEEFEQKTSIKDCGVYTPQGFL
DQWASNASVSHQDQQCPGWVIIGQPAASQVCRTKVIDLSEGISQHAWYPCTISYPYSQLA
QTTFWLRAYFSQPMVAAAVIVHLVTDGTYYGDQKQETISVQLLDTKDQSHDLGLHVLSCR
NNPLIIPVVHDLSQPFYHSQAVRVSFSSPLVAISGVALRSFDNFDPVTLSSCQRGETYSP
AEQSCVHFACEKTDCPELAVENASLNCSSSDRYHGAQCTVSCRTGYVLQIRRDDELIKSQ
TGPSVTVTCTEGKWNKQVACEPVDCSIPDHHQVYAASFSCPEGTTFGSQCSFQCRHPAQL
KGNNSLLTCMEDGLWSFPEALCELMCLAPPPVPNADLQTARCRENKHKVGSFCKYKCKPG
YHVPGSSRKSKKRAFKTQCTQDGSWQEGACVPVTCDPPPPKFHGLYQCTNGFQFNSECRI
KCEDSDASQGLGSNVIHCRKDGTWNGSFHVCQEMQGQCSVPNELNSNLKLQCPDGYAIGS
ECATSCLDHNSESIILPMNVTVRDIPHWLNPTRVERVVCTAGLKWYPHPALIHCVKGCEP
FMGDNYCDAINNRAFCNYDGGDCCTSTVKTKKVTPFPMSCDLQGDCACRDPQAQEHSRKD
LRGYSHG
NT seq 4884 nt   +upstreamnt  +downstreamnt
atgcggctctggagttgggtgctgcacctggggctgctgagcgccgcgctgggctgcggg
ctggccgagcgtccccgccgggcccggagagacccgcgggccggccgacccccgcgcccc
gccgccggcccggccacctgcgccacccgggcggcccgcggccgccgcgcctcgccgccg
ccgccgccgccgccgggcggtgcctgggaagccgtgcgcgtcccccggcggcggcagcag
cgggaggcgaggggcgccaccgaggagccgagcccgccgagccgggcgctctatttcagc
gggcgaggcgagcagctgcgcctccgggccgacctcgagctgccccgggacgcgttcacg
ctgcaagtgtggctgcgagcggaggggggccagaggtctccggcagtgatcacagggctg
tatgacaaatgttcttatatctcacgtgaccgaggatgggtcgtgggcattcacaccatc
agtgaccaagacaacaaagacccacgctactttttctccttgaagacagaccgagcccgg
caagtgaccaccatcaatgcccaccgcagctacctcccaggccagtgggtatacctagct
gccacctatgatgggcagttcatgaagctctatgtgaatggtgcccaggtggccacctct
ggggaacaagtgggtggcatattcagcccactgacccagaagtgcaaagtgctcatgtta
gggggcagtgccctgaatcacaactaccggggctacatcgagcacttcagtctgtggaag
gtggccaggactcagcgggagatactgtctgacatggaaacccatggcgcccacactgct
ctacctcagctcctcctccaggagaactgggacaatgtgaagcatgcctggtcccccatg
aaggatggcagcagccccaaagtggaattcagcaatgcccacggctttctgctggacacg
agtctggagcctcctctgtgcggacagacattgtgtgacaacacagaggtcattgccagc
tacaatcagctctcaagtttccgccagcccaaggtggtgcgctaccgcgtggtcaacctc
tatgaagatgatcataagaacccgacggtgacgcgcgagcaggtggacttccagcaccat
cagctggctgaggccttcaagcaatacaacatctcctgggagctggacgtgctggaggtg
agcaactcctcccttcgccgccgcctcatcctggccaactgtgacatcagcaagattggg
gatgagaactgtgaccccgagtgcaaccacacgctgacgggccacgacggcggggattgc
cgccacctgcgccaccctgccttcgtgaagaagcagcacaacggggtgtgtgacatggac
tgcaactatgaacggttcaactttgatggtggagagtgctgtgaccctgaaatcaccaat
gtcactcagacttgctttgaccccgactctccacacagagcctacttggatgttaatgag
ctgaagaacattcttaaattggatggatcaacacatctcaatattttctttgcaaaatcc
tcagaggaggagttggcaggagtagcaacttggccatgggacaaggaggccctgatgcac
ttaggtggcattgtcttgaacccatctttctatggcatgcctgggcacacccacaccatg
atccatgagattggtcacagcctgggcctctatcacgtcttccgaggcatctcagaaatc
cagtcctgcagtgacccctgcatggagacagagccctccttcgagactggagacctctgc
aatgataccaacccagcccctaaacacaagtcctgtggtgacccagggccaggaaatgac
acctgtggctttcatagcttcttcaacactccttacaacaacttcatgagctatgcagat
gacgactgtacggactccttcacgcccaatcaagtcgccagaatgcactgttacctggac
ctggtctaccagggctggcagccctccaggaaaccagcgcctgttgccctcgccccccaa
gttctgggccacacaacggactctgtgacactggagtggttcccacctatagatggccat
ttctttgaaagagaattgggatcagcatgtcatctttgcctggaagggagaatcctggtg
cagtatgcttccaacgcttcctccccaatgccctgcagcccatcaggacactggagccct
cgtgaagcagaaggtcatcctgatgttgaacagccctgtaagtccagtgtccgcacctgg
agcccaaattcagctgtcaacccacacacggttcctccagcctgccctgagcctcaaggc
tgctacctcgagctggagttcctctaccccttggtccctgagtctctgaccatttgggtg
acctttgtctccactgactgggactctagtggagctgtcaatgacatcaaactgttggct
gtcagtgggaagaacatctccctgggtcctcagaatgtcttctgtgatgtcccactgacc
atcagactctgggacgtgggcgaggaggtgtatggcatccaaatctacacgctggatgag
cacctggagatcgatgctgccatgttgacctccactgcagacaccccactctgtctacag
tgtaagcccctgaagtataaggtggtccgggaccctcctctccagatggatgtggcctcc
atcctacatctcaataggaaattcgtagacatggatctaaatcttggcagtgtgtaccag
tattgggtcataactatttcaggaactgaagagagtgagccatcacctgctgtcacatac
atccatggaagtgggtactgtggcgatggcattatacaaaaagaccaaggtgaacaatgc
gacgacatgaataagatcaatggtgatggctgctcccttttctgccgacaagaagtctcc
ttcaattgtattgatgaacccagccggtgctatttccatgatggtgatggggtatgtgag
gagtttgaacaaaaaaccagcattaaggactgtggtgtctacacgccccagggattcctg
gatcagtgggcatccaatgcttcagtatctcatcaagaccagcaatgcccaggctgggtc
atcatcggacagccagcagcatcccaggtgtgtcgaaccaaggtgatagatctcagtgaa
ggcatttcccagcatgcctggtacccttgcaccatcagctacccatattcccagctggct
cagaccactttttggctccgggcgtatttttctcaaccaatggttgccgcagctgtcatt
gtccacctggtgacggatgggacatattatggggaccaaaagcaggagaccatcagcgtg
cagctgcttgataccaaagatcagagccacgatctaggcctccatgtcctgagctgcagg
aacaatcccctgattatccctgtggtccatgacctcagccagcccttctaccacagccag
gcggtacgtgtgagcttcagttcgcccctggtcgccatctcgggggtggccctccgttcc
ttcgacaactttgaccccgtcaccctgagcagctgccagagaggggagacctacagccct
gccgagcagagctgcgtgcacttcgcatgtgagaaaactgactgtccagagctggctgtg
gagaatgcttctctcaattgctccagcagcgaccgctaccacggtgcccagtgtactgtg
agctgccggacaggctacgtgctccagatacggcgggatgatgagctgatcaagagccag
acgggacccagcgtcacagtgacctgtacagagggcaagtggaataagcaggtggcctgt
gagccagtcgactgcagcatcccagatcaccatcaagtctatgctgcctccttctcctgc
cctgagggcaccacctttggcagtcaatgttccttccagtgccgtcaccctgcacaattg
aaaggcaacaacagcctcctgacctgcatggaggatgggctgtggtccttcccagaggcc
ctgtgtgagctcatgtgcctcgctccaccccctgtgcccaatgcagacctccagaccgcc
cggtgccgagagaataagcacaaggtgggctccttctgcaaatacaaatgcaagcctgga
taccatgtgcctggatcctctcggaagtcaaagaaacgggccttcaagactcagtgtacc
caggatggcagctggcaggagggagcttgtgttcctgtgacctgtgacccacctccacca
aaattccatgggctctaccagtgtactaatggcttccagttcaacagtgagtgtaggatc
aagtgtgaagacagtgatgcctcccagggacttgggagcaatgtcattcattgccggaaa
gatggcacctggaacggctccttccatgtctgccaggagatgcaaggccagtgctcggtt
ccaaacgagctcaacagcaacctcaaactgcagtgccctgatggctatgccatagggtcg
gagtgtgccacctcgtgcctggaccacaacagcgagtccatcatcctgccaatgaacgtg
accgtgcgtgacatcccccactggctgaaccccacacgggtagagagagttgtctgcact
gctggtctcaagtggtatcctcaccctgctctgattcactgtgtcaaaggctgtgagccc
ttcatgggagacaattattgtgatgccatcaacaaccgagccttttgcaactatgacggt
ggggattgctgcacctccacagtgaagaccaaaaaggtcaccccattccctatgtcctgt
gatctacaaggtgactgtgcttgtcgggacccccaggcccaagaacacagccggaaagac
ctccggggatacagccatggctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (62)   
   KEGG ORTHOLOGY (1)   
   RefGene (55)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (71)   
   RefSeq(nuc) (5)   
   GenBank (33)   
   EMBL (33)   
3D Structure (8)   
   PDB (8)   
Protein domain (9)   
   Pfam (9)   
All databases (165)   

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