KEGG   Homo sapiens (human): 5073
Entry
5073              CDS       T01001                                 
Symbol
PARN, DAN, DKCB6, PFBMFT4
Name
(RefSeq) poly(A)-specific ribonuclease
  KO
K01148  poly(A)-specific ribonuclease [EC:3.1.13.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03018  RNA degradation
Network
nt06510  Telomere length regulation
  Element
N01475  Telomerase RNA maturation
Disease
H00507  Dyskeratosis congenita
H02569  Pulmonary fibrosis and/or bone marrow failure, telomere-related
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03018 RNA degradation
    5073 (PARN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    5073 (PARN)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.13  Exoribonucleases producing 5'-phosphomonoesters
    3.1.13.4  poly(A)-specific ribonuclease
     5073 (PARN)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    Other 3'-5' decay factors
     5073 (PARN)
SSDB
Motif
Pfam: CAF1 RNA_bind R3H NCBP3 RRM_1 T6PP_C
Other DBs
NCBI-GeneID: 5073
NCBI-ProteinID: NP_002573
OMIM: 604212
HGNC: 8609
Ensembl: ENSG00000140694
UniProt: O95453 B3KN69
Structure
Position
16:complement(14435701..14630260)
AA seq 639 aa
MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKH
SMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQG
FDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKF
IDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIV
ISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQF
YCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKV
ESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFN
KLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTS
AFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLN
PQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEP
LSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW
NT seq 1920 nt   +upstreamnt  +downstreamnt
atggagataatcaggagcaattttaagagtaatcttcacaaagtgtaccaggccatagag
gaggccgacttcttcgccatcgatggggagttttcaggaatcagtgatggaccttcagtc
tctgcattaacaaatggttttgacactccagaagagaggtatcagaagcttaaaaagcat
tccatggactttttgctatttcagtttggcctttgcacttttaagtatgactacacagat
tcaaagtatataacgaagtcatttaacttctatgttttcccgaaacccttcaatagatcc
tcaccagatgtcaaatttgtttgtcagagctccagcattgactttctagcaagccaggga
tttgattttaataaagtttttcgaaatggaattccatatttaaatcaggaagaagaaaga
cagttaagagagcagtatgatgaaaaacgttcacaggcgaatggtgcaggagctctgtcc
tatgtatctcctaacacttcaaaatgtcctgtcacgattcctgaggatcaaaagaagttt
attgaccaagtggtagagaaaatagaggatttattacaaagtgaagaaaacaagaacttg
gatttagagccatgtaccgggttccaaagaaaactaatttatcagactttgagctggaag
tatccgaaaggcattcatgttgagactttagaaactgaaaagaaggagcgatatatagtt
atcagcaaagtagatgaagaagaacgcaaaagaagagagcagcagaaacatgccaaagaa
caggaggagctgaatgatgctgtgggattttctagagtcattcacgccattgctaattcg
ggaaaacttgttattggacacaatatgctcttggacgtcatgcacacagttcatcagttc
tactgccctctgcctgcggacttaagtgagtttaaagagatgacaacatgtgttttcccc
agactcttggatactaaattgatggccagcacacaaccttttaaggatatcattaacaac
acatcccttgcggaattggaaaagcggttaaaagagacacctttcaaccctcctaaagtt
gaaagtgccgaaggttttccaagttatgacacagcctctgaacaactccacgaggcaggc
tacgatgcctacatcacagggctgtgcttcatctccatggccaattacctaggttctttt
ctcagccctccaaaaattcatgtgtctgccagatcaaaactcattgaacctttttttaac
aagttatttcttatgagggtcatggatatcccctatctaaacttggaaggaccagacttg
cagcctaaacgtgatcatgttctccatgtgacattccccaaagaatggaaaaccagcgac
ctttaccagcttttcagtgcctttggtaacattcagatatcctggattgatgacacatca
gcatttgtttcccttagccagcccgagcaagtaaagattgctgtcaataccagcaaatat
gcagaaagctatcggatccaaacctatgctgaatatatggggagaaaacaggaagagaag
cagatcaaaagaaagtggactgaagatagctggaaggaggctgacagcaaacggttaaac
ccccagtgcataccctacaccctgcagaatcactattaccgcaacaatagttttacagct
cccagcacagtaggaaagagaaatttgagtcctagtcaagaggaagctggcctggaggac
ggagtgtcaggggagatttccgacactgagcttgagcagaccgattcctgtgcagagccc
ctctcagagggaaggaaaaaggccaagaaattaaaaagaatgaagaaggagctttctcca
gcaggaagcatctcgaagaacagccctgccacactctttgaagttcctgacacatggtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (29)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (26)   
DNA sequence (58)   
   RefSeq(nuc) (34)   
   GenBank (12)   
   EMBL (12)   
3D Structure (3)   
   PDB (3)   
Protein domain (6)   
   Pfam (6)   
All databases (120)   

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