KEGG   Homo sapiens (human): 50814
Entry
50814             CDS       T01001                                 
Symbol
NSDHL, H105E3, SDR31E1, XAP104
Name
(RefSeq) NAD(P) dependent steroid dehydrogenase-like
  KO
K07748  sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [EC:1.1.1.170]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00100  Steroid biosynthesis
hsa01100  Metabolic pathways
Module
hsa_M00101  Cholesterol biosynthesis, FPP => cholesterol
Network
nt06034  Cholesterol biosynthesis
  Element
N01624  Cholesterol biosynthesis
Disease
H00496  Congenital hemidysplasia with ichthyosiform nevus and limb defects (CHILD)
H01917  CK syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    50814 (NSDHL)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.170  3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
     50814 (NSDHL)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase GDP_Man_Dehyd NAD_binding_10 RmlD_sub_bind NAD_binding_4 Polysacc_synt_2 NmrA NAD_binding_2
Other DBs
NCBI-GeneID: 50814
NCBI-ProteinID: NP_001123237
OMIM: 300275
HGNC: 13398
Ensembl: ENSG00000147383
UniProt: Q15738 A0A384NPZ7
Structure
Position
X:152831063..152869729
AA seq 373 aa
MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLAR
GYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRV
NYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQE
RAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFV
ENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVA
YYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAME
RTVQSFRHLRRVK
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggaaccagcagttagcgagccaatgagagaccaagtcgcacggactcatttgacagag
gacactcccaaagtgaatgctgacatagaaaaggttaaccagaatcaggccaagagatgc
acagtgatcggtggctctggattcctggggcagcacatggtggagcagttgctggcaaga
ggatatgctgtcaatgtatttgatatccagcaagggtttgataatccccaggtgcggttc
tttctgggtgacctctgcagccgacaggatctgtacccagctctgaaaggtgtaaacaca
gttttccactgtgcgtcacccccaccatccagtaacaacaaggagctcttttatagagtg
aattacattggcaccaagaatgtcattgaaacttgcaaagaggctggggttcagaaactc
attttaaccagcagtgccagtgtcatctttgagggcgtcgatatcaagaatggaactgaa
gaccttccctatgccatgaaacccattgactactacacagagactaagatcttacaggag
agggcagttctgggcgccaacgatcctgagaagaatttcttaaccacagccatccgccct
catggcattttcggcccaagggacccgcagttggtacccatcctcatcgaggcagccagg
aacggcaagatgaagttcgtgattggaaatgggaagaacttggtggacttcacctttgtg
gagaacgtggtccatggacacatcctggcggcagagcagctctcccgagactcgacactg
ggtgggaaggcatttcacatcaccaatgatgagcccatccctttctggacattcctgtct
cgcatcctgacaggcctcaattatgaggcccccaagtaccacatcccctactgggtggcc
tactacctggccctcctgctatccctgctggtgatggtgatcagtcctgtcatccagctg
cagcccaccttcacacccatgcgggtcgcactggctggcacattccactactacagctgc
gagagagccaaaaaggccatgggctaccagccactagtgaccatggatgatgctatggag
aggaccgtgcagagctttcgccacctgcggagggtcaagtga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (2)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (11)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (18)   
   RefSeq(nuc) (8)   
   GenBank (5)   
   EMBL (5)   
3D Structure (2)   
   PDB (2)   
Protein domain (9)   
   Pfam (9)   
All databases (79)   

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