KEGG   Homo sapiens (human): 51102
Entry
51102             CDS       T01001                                 
Symbol
MECR, CGI-63, DYTOABG, ETR1, FASN2B, NRBF1, OPA16
Name
(RefSeq) mitochondrial trans-2-enoyl-CoA reductase
  KO
K07512  mitochondrial enoyl-[acyl-carrier protein] reductase / trans-2-enoyl-CoA reductase [EC:1.3.1.- 1.3.1.38]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00061  Fatty acid biosynthesis
hsa00062  Fatty acid elongation
hsa01100  Metabolic pathways
hsa01212  Fatty acid metabolism
Module
hsa_M00085  Fatty acid elongation in mitochondria
hsa_M00873  Fatty acid biosynthesis in mitochondria, animals
Disease
H00831  Primary dystonia
H01020  Optic atrophy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    51102 (MECR)
   00062 Fatty acid elongation
    51102 (MECR)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.3  Acting on the CH-CH group of donors
   1.3.1  With NAD+ or NADP+ as acceptor
    1.3.1.38  trans-2-enoyl-CoA reductase (NADPH)
     51102 (MECR)
SSDB
Motif
Pfam: ADH_zinc_N ADH_N ADH_zinc_N_2 PALP
Other DBs
NCBI-GeneID: 51102
NCBI-ProteinID: NP_057095
OMIM: 608205
HGNC: 19691
Ensembl: ENSG00000116353
UniProt: Q9BV79
Structure
Position
1:complement(29167696..29230934)
AA seq 373 aa
MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVEL
KNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGFLPELPAVGGNEGVAQVVAVGSNVT
GLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQ
LQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEE
ELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLL
IFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEAS
MKPFISSKQILTM
NT seq 1122 nt   +upstreamnt  +downstreamnt
atgtgggtctgcagtaccctgtggcgggtgcgaacccccgcccggcagtggcgggggctg
ctcccagcttctggctgtcacggacctgccgcctcctcctactccgcatccgccgagcct
gcccgggtccgggcgcttgtctatgggcaccacggggatccagccaaggtcgtcgaactc
aagaacctggagctagctgctgtgagaggatcagatgtccgtgtgaagatgctggcggcc
cctatcaatccatctgacataaatatgatccaaggaaactacggattccttcctgaactg
cctgctgttggagggaacgaaggtgttgcacaggtggtagcggtgggcagcaatgtgacc
gggctgaagccaggagactgggtgattccagcaaatgctggtttaggaacctggcggacc
gaggctgtgttcagcgaggaagcactgatccaagttccgagtgacatccctcttcagagc
gctgccaccctgggtgtcaatccctgcacagcctacaggatgttgatggacttcgagcaa
ctgcagccaggggattctgtcatccagaatgcatccaacagcggagtggggcaagcagtc
atccagatcgccgcagccctgggcctaagaaccatcaatgtggtccgagacagacctgat
atccagaagctgagtgacagactgaagagtctgggggctgagcatgtcatcacagaagag
gagctaagaaggcccgaaatgaaaaacttctttaaggacatgccccagccacggcttgct
ctcaactgtgttggtgggaaaagctccacagagctgctgcggcagttagcgcgtggagga
accatggtaacctatggggggatggccaagcagcccgtcgtagcctctgtgagcctgctc
atttttaaggatctcaaacttcgaggcttttggttgtcccagtggaagaaggatcacagt
ccagaccagttcaaggagctgatcctcacactgtgcgatctcatccgccgaggccagctc
acagcccctgcctgctcccaggtcccgctgcaggactaccagtctgccttggaagcctcc
atgaagcccttcatatcttcaaagcagattctcaccatgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (4)   
   KEGG MODULE (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (33)   
   KEGG COMPOUND (33)   
Chemical reaction (16)   
   KEGG ENZYME (1)   
   KEGG REACTION (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (6)   
   OC (1)   
Protein sequence (25)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (57)   
   RefSeq(nuc) (33)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   Pfam (4)   
All databases (176)   

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