KEGG   Homo sapiens (human): 51185
Entry
51185             CDS       T01001                                 
Symbol
CRBN, MRT2, MRT2A
Name
(RefSeq) cereblon
  KO
K11793  cereblon
Organism
hsa  Homo sapiens (human)
Disease
H00768  Autosomal recessive intellectual developmental disorder
Drug target
Golcadomide (DG03301): D12324 D12832
Mezigdomide: D12000
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    51185 (CRBN)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     51185 (CRBN)
SSDB
Motif
Pfam: LON_substr_bdg Yippee-Mis18
Other DBs
NCBI-GeneID: 51185
NCBI-ProteinID: NP_057386
OMIM: 609262
HGNC: 30185
Ensembl: ENSG00000113851
UniProt: Q96SW2
Structure
Position
3:complement(3149633..3179717)
AA seq 442 aa
MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYL
GADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTF
AVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQA
KVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSW
PRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLK
IGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETL
TVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRS
ALLPTIPDTEDEISPDKVILCL
NT seq 1329 nt   +upstreamnt  +downstreamnt
atggccggcgaaggagatcagcaggacgctgcgcacaacatgggcaaccacctgccgctc
ctgcctgcagagagtgaggaagaagatgaaatggaagttgaagaccaggatagtaaagaa
gccaaaaaaccaaacatcataaattttgacaccagtctgccgacatcacatacataccta
ggtgctgatatggaagaatttcatggcaggactttgcacgatgacgacagctgtcaggtg
attccagttcttccacaagtgatgatgatcctgattcccggacagacattacctcttcag
ctttttcaccctcaagaagtcagtatggtgcggaatttaattcagaaagatagaaccttt
gctgttcttgcatacagcaatgtacaggaaagggaagcacagtttggaacaacagcagag
atatatgcctatcgagaagaacaggattttggaattgagatagtgaaagtgaaagcaatt
ggaagacaaaggttcaaagtccttgagctaagaacacagtcagatggaatccagcaagct
aaagtgcaaattcttcccgaatgtgtgttgccttcaaccatgtctgcagttcaattagaa
tccctcaataagtgccagatatttccttcaaaacctgtctcaagagaagaccaatgttca
tataaatggtggcagaaataccagaagagaaagtttcattgtgcaaatctaacttcatgg
cctcgctggctgtattccttatatgatgctgagaccttaatggacagaatcaagaaacag
ctacgtgaatgggatgaaaatctaaaagatgattctcttccttcaaatccaatagatttt
tcttacagagtagctgcttgtcttcctattgatgatgtattgagaattcagctccttaaa
attggcagtgctatccagcgacttcgctgtgaattagacattatgaataaatgtacttcc
ctttgctgtaaacaatgtcaagaaacagaaataacaaccaaaaatgaaatattcagttta
tccttatgtgggccgatggcagcttatgtgaatcctcatggatatgtgcatgagacactt
actgtgtataaggcttgcaacttgaatctgataggccggccttctacagaacacagctgg
tttcctgggtatgcctggactgttgcccagtgtaagatctgtgcaagccatattggatgg
aagtttacggccaccaaaaaagacatgtcacctcaaaaattttggggcttaacgcgatct
gctctgttgcccacgatcccagacactgaagatgaaataagtccagacaaagtaatactt
tgcttgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (38)   
   RefSeq(nuc) (10)   
   GenBank (14)   
   EMBL (14)   
3D Structure (30)   
   PDB (30)   
Protein domain (2)   
   Pfam (2)   
All databases (111)   

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