KEGG   Homo sapiens (human): 51311
Entry
51311             CDS       T01001                                 
Symbol
TLR8, CD288, IMD98, TLR-8, hTLR8
Name
(RefSeq) toll like receptor 8
  KO
K10170  toll-like receptor 8
Organism
hsa  Homo sapiens (human)
Pathway
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa05171  Coronavirus disease - COVID-19
Network
nt06517  TLR signaling
  Element
N01543  TLR7/8/9-IRF5 signaling pathway
Disease
H00096  Defects of toll-like receptor signaling
Drug target
Enpatoran: D12261
Motolimod: D10716
Selgantolimod: D11871
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    51311 (TLR8)
   04620 Toll-like receptor signaling pathway
    51311 (TLR8)
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    51311 (TLR8)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:hsa04054]
    51311 (TLR8)
   04090 CD molecules [BR:hsa04090]
    51311 (TLR8)
Pattern recognition receptors [BR:hsa04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   51311 (TLR8)
CD molecules [BR:hsa04090]
 Proteins
  51311 (TLR8)
SSDB
Motif
Pfam: LRR_8 LRR_4 TIR LRR_5 TIR_2 LRR_12 LRR_9
Other DBs
NCBI-GeneID: 51311
NCBI-ProteinID: NP_619542
OMIM: 300366
HGNC: 15632
Ensembl: ENSG00000101916
UniProt: Q9NR97
Structure
Position
X:12906620..12923169
AA seq 1041 aa
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
VVLTENDSRYNNMYVDSIKQY
NT seq 3126 nt   +upstreamnt  +downstreamnt
atggaaaacatgttccttcagtcgtcaatgctgacctgcattttcctgctaatatctggt
tcctgtgagttatgcgccgaagaaaatttttctagaagctatccttgtgatgagaaaaag
caaaatgactcagttattgcagagtgcagcaatcgtcgactacaggaagttccccaaacg
gtgggcaaatatgtgacagaactagacctgtctgataatttcatcacacacataacgaat
gaatcatttcaagggctgcaaaatctcactaaaataaatctaaaccacaaccccaatgta
cagcaccagaacggaaatcccggtatacaatcaaatggcttgaatatcacagacggggca
ttcctcaacctaaaaaacctaagggagttactgcttgaagacaaccagttaccccaaata
ccctctggtttgccagagtctttgacagaacttagtctaattcaaaacaatatatacaac
ataactaaagagggcatttcaagacttataaacttgaaaaatctctatttggcctggaac
tgctattttaacaaagtttgcgagaaaactaacatagaagatggagtatttgaaacgctg
acaaatttggagttgctatcactatctttcaattctctttcacacgtgccacccaaactg
ccaagctccctacgcaaactttttctgagcaacacccagatcaaatacattagtgaagaa
gatttcaagggattgataaatttaacattactagatttaagcgggaactgtccgaggtgc
ttcaatgccccatttccatgcgtgccttgtgatggtggtgcttcaattaatatagatcgt
tttgcttttcaaaacttgacccaacttcgatacctaaacctctctagcacttccctcagg
aagattaatgctgcctggtttaaaaatatgcctcatctgaaggtgctggatcttgaattc
aactatttagtgggagaaatagcctctggggcatttttaacgatgctgccccgcttagaa
atacttgacttgtcttttaactatataaaggggagttatccacagcatattaatatttcc
agaaacttctctaaacttttgtctctacgggcattgcatttaagaggttatgtgttccag
gaactcagagaagatgatttccagcccctgatgcagcttccaaacttatcgactatcaac
ttgggtattaattttattaagcaaatcgatttcaaacttttccaaaatttctccaatctg
gaaattatttacttgtcagaaaacagaatatcaccgttggtaaaagatacccggcagagt
tatgcaaatagttcctcttttcaacgtcatatccggaaacgacgctcaacagattttgag
tttgacccacattcgaacttttatcatttcacccgtcctttaataaagccacaatgtgct
gcttatggaaaagccttagatttaagcctcaacagtattttcttcattgggccaaaccaa
tttgaaaatcttcctgacattgcctgtttaaatctgtctgcaaatagcaatgctcaagtg
ttaagtggaactgaattttcagccattcctcatgtcaaatatttggatttgacaaacaat
agactagactttgataatgctagtgctcttactgaattgtccgacttggaagttctagat
ctcagctataattcacactatttcagaatagcaggcgtaacacatcatctagaatttatt
caaaatttcacaaatctaaaagttttaaacttgagccacaacaacatttatactttaaca
gataagtataacctggaaagcaagtccctggtagaattagttttcagtggcaatcgcctt
gacattttgtggaatgatgatgacaacaggtatatctccattttcaaaggtctcaagaat
ctgacacgtctggatttatcccttaataggctgaagcacatcccaaatgaagcattcctt
aatttgccagcgagtctcactgaactacatataaatgataatatgttaaagttttttaac
tggacattactccagcagtttcctcgtctcgagttgcttgacttacgtggaaacaaacta
ctctttttaactgatagcctatctgactttacatcttcccttcggacactgctgctgagt
cataacaggatttcccacctaccctctggctttctttctgaagtcagtagtctgaagcac
ctcgatttaagttccaatctgctaaaaacaatcaacaaatccgcacttgaaactaagacc
accaccaaattatctatgttggaactacacggaaacccctttgaatgcacctgtgacatt
ggagatttccgaagatggatggatgaacatctgaatgtcaaaattcccagactggtagat
gtcatttgtgccagtcctggggatcaaagagggaagagtattgtgagtctggagctaaca
acttgtgtttcagatgtcactgcagtgatattatttttcttcacgttctttatcaccacc
atggttatgttggctgccctggctcaccatttgttttactgggatgtttggtttatatat
aatgtgtgtttagctaaggtaaaaggctacaggtctctttccacatcccaaactttctat
gatgcttacatttcttatgacaccaaagatgcctctgttactgactgggtgataaatgag
ctgcgctaccaccttgaagagagccgagacaaaaacgttctcctttgtctagaggagagg
gattgggacccgggattggccatcatcgacaacctcatgcagagcatcaaccaaagcaag
aaaacagtatttgttttaaccaaaaaatatgcaaaaagctggaactttaaaacagctttt
tacttggctttgcagaggctaatggatgagaacatggatgtgattatatttatcctgctg
gagccagtgttacagcattctcagtatttgaggctacggcagcggatctgtaagagctcc
atcctccagtggcctgacaacccgaaggcagaaggcttgttttggcaaactctgagaaat
gtggtcttgactgaaaatgattcacggtataacaatatgtatgtcgattccattaagcaa
tactaa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (3)   
   KEGG DRUG (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (30)   
   RefSeq(nuc) (2)   
   GenBank (14)   
   EMBL (14)   
3D Structure (36)   
   PDB (36)   
Protein domain (7)   
   Pfam (7)   
All databases (123)   

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