KEGG   Homo sapiens (human): 5133
Entry
5133              CDS       T01001                                 
Symbol
PDCD1, CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1
Name
(RefSeq) programmed cell death 1
  KO
K06744  programmed cell death protein 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa04514  Cell adhesion molecules
hsa04660  T cell receptor signaling pathway
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Network
nt06537  TCR/BCR signaling
  Element
N01165  PDL/PD1-SHP-PI3K signaling pathway
Disease
H00080  Systemic lupus erythematosus
H01490  Multiple sclerosis
H01812  Rasmussen encephalitis
Drug target
Balstilimab: D11820
Budigalimab: D11643
Cadonilimab: D12190
Cemiplimab: D11108<JP/US>
Cetrelimab: D11488
Dostarlimab: D11366<US>
Eciskafusp alfa: D12791
Ivonescimab: D12808
Izuralimab: D12195
Nivolumab: D10316<JP/US>
Pacmilimab: D11948
Pembrolizumab: D10574<JP/US>
Penpulimab: D12198
Peresolimab: D12231
Pidilizumab: D10390
Retifanlimab: D11827<US>
Rilvegostomig: D12764
Rosnilimab: D12223
Sasanlimab: D12839
Serplulimab: D12751
Sintilimab: D12119
Spartalizumab: D11605
Tislelizumab: D11487<US>
Toripalimab: D12202<US>
Volrustomig: D12347
Vudalimab: D12186
Zeluvalimab: D12332
Zimberelimab: D12063
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04514 Cell adhesion molecules
    5133 (PDCD1)
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    5133 (PDCD1)
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5133 (PDCD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:hsa04090]
    5133 (PDCD1)
CD molecules [BR:hsa04090]
 Proteins
  5133 (PDCD1)
SSDB
Motif
Pfam: V-set ig Ig_3 Ig_2 I-set
Other DBs
NCBI-GeneID: 5133
NCBI-ProteinID: NP_005009
OMIM: 600244
HGNC: 8760
Ensembl: ENSG00000188389
UniProt: Q15116 A0A0M3M0G7
Structure
Position
2:complement(241849884..241858894)
AA seq 288 aa
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTS
ESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGT
YLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGS
LVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVP
CVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
NT seq 867 nt   +upstreamnt  +downstreamnt
atgcagatcccacaggcgccctggccagtcgtctgggcggtgctacaactgggctggcgg
ccaggatggttcttagactccccagacaggccctggaacccccccaccttctccccagcc
ctgctcgtggtgaccgaaggggacaacgccaccttcacctgcagcttctccaacacatcg
gagagcttcgtgctaaactggtaccgcatgagccccagcaaccagacggacaagctggcc
gccttccccgaggaccgcagccagcccggccaggactgccgcttccgtgtcacacaactg
cccaacgggcgtgacttccacatgagcgtggtcagggcccggcgcaatgacagcggcacc
tacctctgtggggccatctccctggcccccaaggcgcagatcaaagagagcctgcgggca
gagctcagggtgacagagagaagggcagaagtgcccacagcccaccccagcccctcaccc
aggccagccggccagttccaaaccctggtggttggtgtcgtgggcggcctgctgggcagc
ctggtgctgctagtctgggtcctggccgtcatctgctcccgggccgcacgagggacaata
ggagccaggcgcaccggccagcccctgaaggaggacccctcagccgtgcctgtgttctct
gtggactatggggagctggatttccagtggcgagagaagaccccggagccccccgtgccc
tgtgtccctgagcagacggagtatgccaccattgtctttcctagcggaatgggcacctca
tcccccgcccgcaggggctcagctgacggccctcggagtgcccagccactgaggcctgag
gatggacactgctcttggcccctctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (6)   
   KEGG DISEASE (3)   
   OMIM (3)   
Drug (28)   
   KEGG DRUG (28)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (40)   
   RefSeq(nuc) (4)   
   GenBank (18)   
   EMBL (18)   
3D Structure (32)   
   PDB (32)   
Protein domain (5)   
   Pfam (5)   
All databases (140)   

Download RDF
DBGET integrated database retrieval system