KEGG T01001: 5136

Homo sapiens (human): 5136

Entry

5136              CDS       T01001

Symbol

PDE1A, CAM-PDE_1A, CAM-PDE-1A, HCAM-1, HCAM1, HSPDE1A

Name

(RefSeq) phosphodiesterase 1A

K13755

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase [EC:3.1.4.17]

Organism

hsa Homo sapiens (human)

Pathway

hsa00230

Purine metabolism

hsa01100

Metabolic pathways

hsa04020

Calcium signaling pathway

hsa04740

Olfactory transduction

hsa04742

Taste transduction

hsa04924

Renin secretion

hsa05032

Morphine addiction

Drug target

Aminophylline (DG01062):

D00227 D05429<JP> D11630<US>

Bemoradan:

D03075

Bucladesine (DG00230):

D01238<JP> D07546

Choline theophyllinate:

D02017

Diprophylline:

D00691<JP>

Enprofylline:

D04006

Flavoxate (DG00477):

D00718<JP/US> D07961

Lenrispodun (DG03118):

D11883 D11884

Moxaverine (DG00045):

D07089 D08238

Oxagrelate:

D05278

Papaverine (DG00043):

D02218<JP> D07425 D07439

Prinoxodan:

D05612

Proxyphylline:

D01771<JP>

Theophylline (DG01061):

D00371<JP/US> D01712 D06103 D06104

Theosalicin:

D09822

Tibenelast sodium:

D06132

Trapidil:

D01220<JP>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    5136 (PDE1A)
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    5136 (PDE1A)
09150 Organismal Systems
  09152 Endocrine system
   04924 Renin secretion
    5136 (PDE1A)
  09157 Sensory system
   04740 Olfactory transduction
    5136 (PDE1A)
   04742 Taste transduction
    5136 (PDE1A)
09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    5136 (PDE1A)
Enzymes [BR:hsa01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.17  3',5'-cyclic-nucleotide phosphodiesterase
     5136 (PDE1A)

SSDB

Motif

Pfam:

PDEase_I PDEase_I_N

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Position

2:complement(182140041..182716797)

AA seq 535 aa
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ

NT seq 1608 nt +upstreamnt +downstreamnt
atggggtctagtgccacagagattgaagaattggaaaacaccacttttaagtatcttaca
ggagaacagactgaaaaaatgtggcagcgcctgaaaggaatactaagatgcttggtgaag
cagctggaaagaggtgatgttaacgtcgtcgacttaaagaagaatattgaatatgcggca
tctgtgctggaagcagtttatatcgatgaaacaagaagacttctggatactgaagatgag
ctcagtgacattcagactgactcagtcccatctgaagtccgggactggttggcttctacc
tttacacggaaaatggggatgacaaaaaagaaacctgaggaaaaaccaaaatttcggagc
attgtgcatgctgttcaagctggaatttttgtggaaagaatgtaccgaaaaacatatcat
atggttggtttggcatatccagcagctgtcatcgtaacattaaaggatgttgataaatgg
tctttcgatgtatttgccctaaatgaagcaagtggagagcatagtctgaagtttatgatt
tatgaactgtttaccagatatgatcttatcaaccgtttcaagattcctgtttcttgccta
atcacctttgcagaagctttagaagttggttacagcaagtacaaaaatccatatcacaat
ttgattcatgcagctgatgtcactcaaactgtgcattacataatgcttcatacaggtatc
atgcactggctcactgaactggaaattttagcaatggtctttgctgctgccattcatgat
tatgagcatacagggacaacaaacaactttcacattcagacaaggtcagatgttgccatt
ttgtataatgatcgctctgtccttgagaatcaccacgtgagtgcagcttatcgacttatg
caagaagaagaaatgaatatcttgataaatttatccaaagatgactggagggatcttcgg
aacctagtgattgaaatggttttatctacagacatgtcaggtcacttccagcaaattaaa
aatataagaaacagtttgcagcagcctgaagggattgacagagccaaaaccatgtccctg
attctccacgcagcagacatcagccacccagccaaatcctggaagctgcattatcggtgg
accatggccctaatggaggagtttttcctgcagggagataaagaagctgaattagggctt
ccattttccccactttgtgatcggaagtcaaccatggtggcccagtcacaaataggtttc
atcgatttcatagtagagccaacattttctcttctgacagactcaacagagaaaattgtt
attcctcttatagaggaagcctcaaaagccgaaacttcttcctatgtggcaagcagctca
accaccattgtggggttacacattgctgatgcactaagacgatcaaatacaaaaggctcc
atgagtgatgggtcctattccccagactactcccttgcagcagtggacctgaagagtttc
aagaacaacctggtggacatcattcagcagaacaaagagaggtggaaagagttagctgca
caagaagcaagaaccagttcacagaagtgtgagtttattcatcagtaa

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