KEGG   Homo sapiens (human): 51366
Entry
51366             CDS       T01001                                 
Symbol
UBR5, DD5, EDD, EDD1, HYD
Name
(RefSeq) ubiquitin protein ligase E3 component n-recognin 5
  KO
K10593  E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04120  Ubiquitin mediated proteolysis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    51366 (UBR5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:hsa04121]
    51366 (UBR5)
Enzymes [BR:hsa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     51366 (UBR5)
Ubiquitin system [BR:hsa04121]
 Ubiquitin ligases (E3)
  HECT type E3
   51366 (UBR5)
SSDB
Motif
Pfam: HECT E3_UbLigase_EDD PABP zf-UBR
Other DBs
NCBI-GeneID: 51366
NCBI-ProteinID: NP_056986
OMIM: 608413
HGNC: 16806
Ensembl: ENSG00000104517
UniProt: O95071
Structure
Position
8:complement(102252273..102412700)
AA seq 2799 aa
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
NT seq 8400 nt   +upstreamnt  +downstreamnt
atgacgtccatccatttcgtggttcacccgctgccgggcaccgaggaccagctcaatgac
aggttacgagaagtttctgagaagctgaacaaatataatttaaacagccacccccctttg
aatgtattggaacaggctactattaaacagtgtgtggtgggaccaaatcatgctgccttt
cttcttgaggatggtagagtttgcaggattggtttttcagtacagccagacagattggaa
ttgggtaaacctgataataatgatgggtcaaagttgaacagcaactcgggggcagggagg
acgtcaaggcctggtaggacaagcgactctccatggtttctctcaggttctgagactcta
ggcaggctggcaggcaacaccttaggaagccgctggagttctggagtgggtggaagtggt
ggaggatcctctggtaggtcatcagctggagctcgagattcccgccggcagactcgagtt
attcggacaggacgggatcgagggtctgggcttttgggcagtcagccccagccagttatt
ccagcatctgtcattccagaggagctgatttcacaggcccaagttgttttacaaggcaaa
tccagaagtgtcattattcgagaacttcagagaacaaatcttgatgtgaaccttgctgta
aataatttacttagccgggatgatgaagatggagatgatggggatgatacagccagcgaa
tcttatttgcctggagaggatcttatgtctctccttgatgccgacattcattctgcccac
ccaagtgtcattattgatgcagatgccatgttttctgaagacattagctattttggttac
ccttcttttcgtcgttcatcactttccaggctaggctcatctcgagttctccttcttccc
ttagagagagactctgagctgttgcgtgaacgtgaatccgttttacgtttacgtgaacga
aggtggcttgatggagcctcatttgataatgaaaggggttctaccagcaaggaaggagag
ccaaacttggataagaagaatacacctgttcaaagtccagtatctctaggagaagatttg
cagtggtggcctgataaggatggaacaaaattcatctgtattggggctctgtattctgaa
cttctggctgtcagcagtaaaggagaactttatcagtggaaatggagtgaatctgagcct
tacagaaatgcccagaatccttcattacatcatccacgagcaacatttttggggttaacc
aatgaaaagatagtcctcctgtctgcaaatagcataagagcaactgtagctacagaaaat
aacaaggttgctacatgggtggatgaaactttaagttctgtggcttctaaattagagcac
actgctcagacttactctgaacttcaaggagagcggatagtttctttacattgctgtgcc
ctttacacctgcgctcagctggaaaacagtttatattggtggggtgtagttccttttagt
caaaggaagaaaatgttagagaaagctagagcaaaaaataaaaagcctaaatccagtgct
ggtatttcttcaatgccgaacatcactgttggtacccaggtatgcttgagaaataatcct
ctttatcatgctggagcagttgcattttcaattagtgctgggattcctaaagttggtgtc
ttaatggagtcagtttggaatatgaatgacagctgtagatttcaacttagatctcctgaa
agcttgaaaaacatggaaaaagctagcaaaactactgaagctaagcctgaaagtaagcag
gagccagtgaaaacagaaatgggtcctccaccatctccagcatccacgtgtagtgatgca
tcctcaattgccagcagtgcatcaatgccatacaaacgacgacggtcaacccctgcacca
aaagaagaggaaaaggtgaatgaagagcagtggtctcttcgggaagtggtttttgtggaa
gatgtcaagaatgttcctgttggcaaggtgctaaaagtagatggtgcctatgttgctgta
aaatttccaggaacctccagtaatactaactgtcagaacagctctggtccagatgctgac
ccttcttctctcctgcaggattgtaggttacttagaattgatgaattgcaggttgtcaaa
actggtggaacaccgaaggttcccgactgtttccaaaggactcctaaaaagctttgtata
cctgaaaaaacagaaatattagcagtgaatgtagattccaaaggtgttcatgctgttctg
aagactggaaattgggtacgatactgtatctttgatcttgctacaggaaaagcagaacag
gaaaataattttcctacaagcagcattgctttccttggtcagaatgagaggaatgtagcc
attttcactgctggacaggaatctcccattattcttcgagatggaaatggtaccatctac
ccaatggccaaagattgcatgggaggaataagggatcccgattggctggatcttccacct
attagtagtcttggaatgggtgtgcattctttaataaatcttcctgccaattcaacaatc
aaaaagaaagctgctgttatcatcatggctgtagagaaacaaaccttaatgcaacacatt
ctgcgctgtgactatgaggcctgtcgacaatatctaatgaatcttgagcaagcggttgtt
ttagagcagaatctacagatgctgcagacattcatcagccacagatgtgatggaaatcga
aatattttgcatgcttgtgtatcagtttgctttccaaccagcaataaagaaactaaagaa
gaagaggaagcggagcgttctgaaagaaatacatttgcagaaaggctttctgctgttgag
gccattgcaaatgcaatatcagttgtttcaagtaatggcccaggtaatcgggctggatca
tcaagtagccgaagtttgagattacgggaaatgatgagacgttcgttgagagcagctggt
ttgggtagacatgaagctggagcttcatccagtgaccaccaggatccagtttcacccccc
atagctccccctagttgggttcctgaccctcctgcgatggatcctgatggtgacattgat
tttatcctggcccccgctgtgggatctcttaccacagcagcaaccggtactggtcaagga
ccaagcacctccactattccaggtccttccacagagccatctgtagtagaatccaaggat
cgaaaggcgaatgctcattttatattgaaattgttatgtgacagtgtggttctccagccc
tatctacgagaacttctttctgccaaggatgcaagagggatgaccccatttatgtcagct
gtaagtggccgagcttatcctgctgcaattaccatcttagaaactgctcagaaaattgca
aaagctgaaatatcctcaagtgaaaaagaggaagatgtattcatgggaatggtttgccca
tcaggtaccaaccctgatgactctcctttatatgttttatgttgtaatgacacttgcagt
tttacatggactggagcagagcacattaaccaggatatttttgagtgtcgaacttgtggc
ttgctggagtcactgtgttgttgtacggaatgtgcaagggtttgtcataaaggtcatgat
tgcaaactcaaacggacatcaccaacagcctactgtgattgttgggagaaatgtaaatgt
aaaactcttattgctggacagaaatctgctcgtcttgatctactttatcgcctgctcact
gctactaatctggttactctgccaaacagcaggggagagcacctcttactattcttagta
cagacagtcgcaaggcagacggtggagcattgtcaatacaggccacctcgaatcagggaa
gatcgtaaccgaaaaacagccagtcctgaagattcagatatgccagatcatgatttagag
cctccaagatttgcccagcttgcattggagcgtgttctacaggactggaatgccttgaaa
tctatgattatgtttgggtcgcaggagaataaagaccctcttagtgccagcagtagaata
ggccatcttttgccagaagagcaagtatacctcaatcagcaaagtggcacaattcggctg
gactgtttcactcattgccttatagttaagtgtacagcagatattttgcttttagatact
ctactaggtacactagtgaaagaactccaaaacaaatatacacctggacgtagagaagaa
gctattgctgtgacaatgaggtttctacgttcagtggcaagagtttttgttattctgagt
gtggaaatggcttcatccaaaaagaaaaacaactttattccacagccaattggaaaatgc
aagcgtgtattccaagcattgctaccttacgctgtggaagaattgtgcaacgtagcagag
tcactgattgttcctgtcagaatggggattgctcgtccaactgcaccatttaccctggct
agtactagcatagatgccatgcagggcagtgaagaattattttcagtggaaccactacca
ccacgaccatcatctgatcagtctagcagctccagtcagtctcagtcatcctacatcatc
aggaatccacagcagaggcgcatcagccagtcacagcccgttcggggcagagatgaagaa
caggatgatattgtttcagcagatgtggaagaggttgaggtggtggagggtgtggctgga
gaagaggatcatcatgatgaacaggaagaacacggggaagaaaatgctgaggcagaggga
caacatgatgagcatgatgaagacgggagtgatatggagctggacttgttagcagcagct
gaaacagaaagtgatagtgaaagtaaccacagcaaccaagataatgctagtgggcgcaga
agcgttgtcactgcagcaactgctggttcagaagcaggagcaagcagtgttcctgccttc
ttttctgaagatgattctcaatcgaatgactcaagtgattctgatagcagtagtagtcag
agtgacgacatagaacaggagacctttatgcttgatgagccattagaaagaaccacaaat
agctcccatgccaatggtgctgcccaagctccccgttcaatgcagtgggctgtccgcaac
acccagcatcagcgagcagccagtacagccccttccagtacatctacaccagcagcaagt
tcagcgggtttgatttatattgatccttcaaacttacgccggagtggtaccatcagtaca
agtgctgcagctgcagcagctgctttggaagctagcaacgccagcagttacctaacatct
gcaagcagtttagccagggcttacagcattgtcattagacaaatctcggacttgatgggc
cttattcctaagtataatcacctagtatactctcagattccagcagctgtgaaattgact
taccaagatgcagtaaacttacagaactatgtagaagaaaagcttattcccacttggaac
tggatggtcagtattatggattctactgaagctcaattacgttatggttctgcattagca
tctgctggtgatcctggacatccaaatcatcctcttcacgcttctcagaattcagcgaga
agagagaggatgactgcgcgagaagaagctagcttacgaacacttgaaggcagacgacgt
gccaccttgcttagcgcccgtcaaggaatgatgtctgcacgaggagacttcctaaattat
gctctgtctctaatgcggtctcataatgatgagcattctgatgttcttccagttttggat
gtttgctcattgaagcatgtggcatatgtttttcaagcacttatatactggattaaggca
atgaatcagcagacaacattggatacacctcaactagaacgcaaaaggacgcgagaactc
ttggaactgggtattgataatgaagattcagaacatgaaaatgatgatgacaccaatcaa
agtgctactttgaatgataaggatgatgactctcttcctgcagaaactggccaaaaccat
ccatttttccgacgttcagactccatgacattccttgggtgtatacccccaaatccattt
gaagtgcctctggctgaagccatccccttggctgatcagccacatctgttgcagccaaat
gctagaaaggaggatctttttggccgtccaagtcagggtctttattcttcatctgccagt
agtgggaaatgtttaatggaggttacagtggatagaaactgcctagaggttcttccaaca
aaaatgtcttatgctgccaatctgaaaaatgtaatgaacatgcaaaaccggcaaaaaaaa
gaaggggaagaacagcccgtgctgccagaagaaactgagagttcaaaaccagggccatct
gctcatgatcttgctgcacaattaaaaagtagcttactagcagaaataggacttactgaa
agtgaagggccacctctcacatctttcaggccacagtgtagctttatgggaatggttatt
tcccatgatatgctgctaggacgttggcgcctttctttagaactgttcggcagggtattc
atggaagatgttggagcagaacctggatcaatcctaactgaattgggtggttttgaggta
aaagaatcaaaattccgcagagaaatggaaaaactgagaaaccagcagtcaagagatttg
tcactagaggttgatcgggatcgagatcttctcattcagcagactatgaggcagcttaac
aatcactttggtcgaagatgtgctactacaccaatggctgtacacagagtaaaagtcaca
tttaaggatgagccaggagagggcagtggtgtagcacgaagtttttatacagccattgca
caagcatttttatcaaatgaaaaattgccaaatctagagtgtatccaaaatgccaacaaa
ggcacccacacaagtttaatgcagagattaaggaaccgaggagagagagaccgggaaagg
gagagagaaagggaaatgaggaggagtagtggtttgcgagcaggttctcggagggaccgg
gatagagactttagaagacagctttccatcgacactaggccctttagaccagcctctgaa
gggaatcctagcgatgatcctgagcctttgccagcacatcggcaggcacttggagagagg
ctttatcctcgtgtacaagcaatgcaaccagcatttgcaagtaaaatcactggcatgttg
ttggaattatccccagctcagctgcttctccttctagcaagtgaggattctctgagagca
agagtggatgaggccatggaactcattattgcacatggacgggaaaatggagctgatagt
atcctggatcttggattagtagactcctcagaaaaggtacagcaggaaaaccgaaagcgc
catggctctagtcgaagtgtagtagatatggatttagatgatacagatgatggtgatgac
aatgcccctttgttttaccaacctgggaaaagaggattttatactccaaggcctggcaag
aacacagaagcaaggttgaattgtttcagaaacattggcaggattcttggactatgtctg
ttacagaatgaactatgtcctatcacattgaatagacatgtaattaaagtattgcttggt
agaaaagtcaattggcatgattttgctttttttgatcctgtaatgtatgagagtttgcgg
caactaatcctcgcgtctcagagttcagatgctgatgctgttttctcagcaatggatttg
gcatttgcaattgacctgtgtaaagaagaaggtggaggacaggttgaactcattcctaat
ggtgtaaatataccagtcactccacagaatgtatatgagtatgtgcggaaatacgcagaa
cacagaatgttggtagttgcagaacagcccttacatgcaatgaggaaaggtctactagat
gtgcttccaaaaaattcattagaagatttaacggcagaagattttaggcttttggtaaat
ggctgcggtgaagtcaatgtgcaaatgctgatcagttttacctctttcaatgatgaatca
ggagaaaatgctgagaagcttctgcagttcaagcgttggttctggtcaatagtagagaag
atgagcatgacagaacgacaagatcttgtttacttttggacatcaagcccatcactgcca
gccagtgaagaaggattccagcctatgccctcaatcacaataagaccaccagatgaccaa
catcttcctactgcaaatacttgcatttctcgactttacgtcccactctattcctctaaa
cagattctcaaacagaaattgttactcgccattaagaccaagaattttggttttgtgtag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (73)   
   KEGG ORTHOLOGY (1)   
   RefGene (67)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (16)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (14)   
DNA sequence (38)   
   RefSeq(nuc) (14)   
   GenBank (12)   
   EMBL (12)   
3D Structure (11)   
   PDB (11)   
Protein domain (4)   
   Pfam (4)   
All databases (149)   

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