KEGG   Homo sapiens (human): 5146
Entry
5146              CDS       T01001                                 
Symbol
PDE6C, ACHM5, COD4, PDEA2
Name
(RefSeq) phosphodiesterase 6C
  KO
K13757  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [EC:3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
Disease
H00481  Cone-rod dystrophy and cone dystrophy
H00971  Achromatopsia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    5146 (PDE6C)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     5146 (PDE6C)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3
Other DBs
NCBI-GeneID: 5146
NCBI-ProteinID: NP_006195
OMIM: 600827
HGNC: 8787
Ensembl: ENSG00000095464
UniProt: P51160
Structure
Position
10:93612537..93666010
AA seq 858 aa
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESA
LCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPT
SKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLL
ATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRS
QILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGE
VEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICN
MMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEY
ITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVD
VIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKV
PVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAF
CHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFET
VIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMT
ACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFI
DFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKA
AEDSGGGDDKKSKTCLML
NT seq 2577 nt   +upstreamnt  +downstreamnt
atgggtgagatcaaccaagttgccgtggagaaatacctggaggagaaccctcagtttgcc
aaggagtactttgacaggaagttgcgggtggaggtgctgggagaaatcttcaagaacagc
caggtgccagtccagtccagcatgtccttctctgagctgacccaggtggaggagtcagcc
ctgtgcttggagctgctgtggaccgtgcaggaggaggggggcaccccagagcagggggtt
cacagggccctgcagaggctggcccacctgctccaggctgaccgctgcagcatgttcctg
tgccggtcccggaacggcatacctgaggtggcctctaggttgctggatgtcacccccacc
tccaagtttgaggacaacctggtgggccctgacaaagaagttgtgtttccattggacatt
gggatagtgggttgggctgctcacacgaagaaaactcataatgtcccagatgtgaaaaag
aacagccatttttctgacttcatggacaagcaaactgggtatgtcactaagaacctgctg
gcaaccccgatcgtggtgggcaaggaggttcttgctgtgatcatggcagttaacaaagta
aatgcatctgaattttccaaacaggatgaagaggtcttttccaaatacctcaactttgtg
tctatcatcctaaggcttcatcacaccagctacatgtacaatattgaatcccgaagaagc
cagatccttatgtggtcagccaataaagtatttgaagaactcacagatgttgagcgacag
tttcacaaagcgctctacacggttagatcatatctgaactgtgaacgatactccattgga
ctgctggacatgaccaaggagaaggaattctacgatgaatggccaatcaagcttggagaa
gtagagccttataaaggtccaaagacacctgatggcagggaagtcaacttttataaaatc
attgattacattttacatggaaaagaagagatcaaagtgattccgacgcctcctgcagac
cactggacactcattagtgggttgccaacatatgttgctgaaaatggatttatctgtaac
atgatgaatgcccctgcggatgaatacttcacatttcagaaaggacctgtagacgaaact
ggttgggtcattaagaatgttttgtccctgcctattgtcaacaagaaagaagatattgtg
ggagtggctacattttacaacaggaaggatggaaaacctttcgatgagcatgatgaatac
attaccgagactctcacacaatttcttggatggtctcttttaaatactgacacctacgat
aagatgaataagctagaaaacagaaaggacattgctcaggaaatgctcatgaaccaaacc
aaagccactcctgaagaaattaagtccattttgaaatttcaagagaagttaaatgttgat
gtaattgacgactgtgaagaaaaacaacttgttgcaattttgaaagaggacttgccagac
ccacgctcagcagaactgtacgaattccgcttcagtgacttcccccttacagagcacgga
ttgattaaatgtggaatacgactgttttttgaaataaatgtggtggagaaattcaaagta
cctgtagaggttcttaccagatggatgtacactgtgaggaaagggtaccgagctgtcact
taccacaattggcggcatgggttcaacgtggggcagaccatgtttactttgctgatgaca
ggaagattaaagaagtactacacagatctcgaagcctttgccatgcttgctgctgctttc
tgccatgatattgaccacagaggcaccaataatttgtaccagatgaaatccacgtctcca
ttagcaagacttcatggttcttctattttggagaggcaccacctggagtacagtaagact
ctgttgcaggatgagagtttaaacatcttccagaacctaaataagcggcagtttgaaaca
gttattcatttgttcgaggtcgcaataatagcaactgacctggctttatatttcaagaag
aggaccatgtttcaaaaaattgttgatgcctgtgaacaaatgcaaacggaagaagaagcc
atcaaatatgtaactgttgatccaaccaagaaagagattatcatggcaatgatgatgacg
gcatgtgacttgtctgctattaccaagccctgggaggtgcaaagtcaggtagcacttatg
gttgcaaatgaattttgggaacaaggagatctggagagaacagtgttgcagcaacaaccc
attcctatgatggacagaaacaaaagagatgaattacctaaacttcaagttggatttatt
gattttgtttgtacttttgtatataaggagttctcacggtttcacaaagaaatcacacct
atgctgagtggtcttcagaataacagagtagaatggaaatcactagctgatgagtatgat
gcaaagatgaaggtcattgaagaggaggcaaaaaagcaagaaggaggagccgaaaaagct
gctgaagattcaggaggtggtgatgacaaaaagtccaaaacatgtttaatgttgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
3D Structure (3)   
   PDB (3)   
Protein domain (4)   
   Pfam (4)   
All databases (45)   

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