KEGG T01001: 51561

Homo sapiens (human): 51561

Entry

51561             CDS       T01001

Symbol

IL23A, IL-23, IL-23A, IL23P19, P19, SGRF

Name

(RefSeq) interleukin 23 subunit alpha

K05426

interleukin 23 subunit alpha

Organism

hsa Homo sapiens (human)

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04625

C-type lectin receptor signaling pathway

hsa04630

JAK-STAT signaling pathway

hsa04659

Th17 cell differentiation

hsa05133

Pertussis

hsa05152

Tuberculosis

hsa05200

Pathways in cancer

hsa05321

Inflammatory bowel disease

hsa05323

Rheumatoid arthritis

Network

nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06219  JAK-STAT signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06266  Non-small cell lung cancer
nt06276  Chronic myeloid leukemia
nt06518  JAK-STAT signaling

Element

N00053

Cytokine-Jak-STAT signaling pathway

N01557

IL12/23 to Jak-STAT signaling pathway

Drug target

Apilimod mesylate:

D06556

Brazikumab:

D10912

Briakinumab:

D09588

Guselkumab:

D10438<JP/US>

Mirikizumab:

D11123<JP/US>

Risankizumab:

D11052<JP/US>

Tildrakizumab:

D10400<JP/US>

Ustekinumab:

D09214<JP/US>

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    51561 (IL23A)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    51561 (IL23A)
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    51561 (IL23A)
   04659 Th17 cell differentiation
    51561 (IL23A)
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    51561 (IL23A)
  09171 Infectious disease: bacterial
   05133 Pertussis
    51561 (IL23A)
   05152 Tuberculosis
    51561 (IL23A)
  09163 Immune disease
   05323 Rheumatoid arthritis
    51561 (IL23A)
   05321 Inflammatory bowel disease
    51561 (IL23A)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hsa04052]
    51561 (IL23A)
Cytokines and neuropeptides [BR:hsa04052]
Cytokines
  Interleukins
   51561 (IL23A)

SSDB

Motif

Pfam:

IL23 IL6

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

12:56338884..56340410

AA seq 189 aa
MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEG
DEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSP
VGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVF
AHGAATLSP

NT seq 570 nt +upstreamnt +downstreamnt
atgctggggagcagagctgtaatgctgctgttgctgctgccctggacagctcagggcaga
gctgtgcctgggggcagcagccctgcctggactcagtgccagcagctttcacagaagctc
tgcacactggcctggagtgcacatccactagtgggacacatggatctaagagaagaggga
gatgaagagactacaaatgatgttccccatatccagtgtggagatggctgtgacccccaa
ggactcagggacaacagtcagttctgcttgcaaaggatccaccagggtctgattttttat
gagaagctgctaggatcggatattttcacaggggagccttctctgctccctgatagccct
gtgggccagcttcatgcctccctactgggcctcagccaactcctgcagcctgagggtcac
cactgggagactcagcagattccaagcctcagtcccagccagccatggcagcgtctcctt
ctccgcttcaaaatccttcgcagcctccaggcctttgtggctgtagccgcccgggtcttt
gcccatggagcagcaaccctgagtccctaa

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