KEGG   Homo sapiens (human): 5158
Entry
5158              CDS       T01001                                 
Symbol
PDE6B, CSNB3, CSNBAD2, GMP-PDEbeta, PDEB, RP40, rd1
Name
(RefSeq) phosphodiesterase 6B
  KO
K13756  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [EC:3.1.4.35]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00230  Purine metabolism
hsa01100  Metabolic pathways
hsa04744  Phototransduction
Disease
H00527  Retinitis pigmentosa
H00787  Congenital stationary night blindness
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    5158 (PDE6B)
 09150 Organismal Systems
  09157 Sensory system
   04744 Phototransduction
    5158 (PDE6B)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.35  3',5'-cyclic-GMP phosphodiesterase
     5158 (PDE6B)
SSDB
Motif
Pfam: PDEase_I GAF GAF_2 GAF_3
Other DBs
NCBI-GeneID: 5158
NCBI-ProteinID: NP_000274
OMIM: 180072
HGNC: 8786
Ensembl: ENSG00000133256
UniProt: P35913
Position
4:625573..670782
AA seq 854 aa
MSLSEEQARSFLDQNPDFARQYFGKKLSPENVAAACEDGCPPDCDSLRDLCQVEESTALL
ELVQDMQESINMERVVFKVLRRLCTLLQADRCSLFMYRQRNGVAELATRLFSVQPDSVLE
DCLVPPDSEIVFPLDIGVVGHVAQTKKMVNVEDVAECPHFSSFADELTDYKTKNMLATPI
MNGKDVVAVIMAVNKLNGPFFTSEDEDVFLKYLNFATLYLKIYHLSYLHNCETRRGQVLL
WSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWSVLMGESQPY
SGPRTPDGREIVFYKVIDYVLHGKEEIKVIPTPSADHWALASGLPSYVAESGFICNIMNA
SADEMFKFQEGALDDSGWLIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDEVLMES
LTQFLGWSVMNTDTYDKMNKLENRKDIAQDMVLYHVKCDRDEIQLILPTRARLGKEPADC
DEDELGEILKEELPGPTTFDIYEFHFSDLECTELDLVKCGIQMYYELGVVRKFQIPQEVL
VRFLFSISKGYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDID
HRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLSEETLNIYQNLNRRQHEHVIHLM
DIAIIATDLALYFKKRAMFQKIVDESKNYQDKKSWVEYLSLETTRKEIVMAMMMTACDLS
AITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCT
FVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEKEEEERVAAKKVGTEIC
NGGPAPKSSTCCIL
NT seq 2565 nt   +upstreamnt  +downstreamnt
atgagcctcagtgaggagcaggcccggagctttctggaccagaaccccgattttgcccgc
cagtactttgggaagaaactgagccctgagaatgtggccgcggcctgcgaggacgggtgc
ccgccggactgcgacagcctccgggacctctgccaggtggaggagagcacggcgctgctg
gagctggtgcaggatatgcaggagagcatcaacatggagcgcgtggtcttcaaggtcctg
cggcgcctctgcaccctcctgcaggccgaccgctgcagcctcttcatgtaccgccagcgc
aacggcgtggccgagctggccaccaggcttttcagcgtgcagccggacagcgtcctggag
gactgcctggtgccccccgactccgagatcgtcttcccactggacatcggggtcgtgggc
cacgtggctcagaccaaaaagatggtgaacgtcgaggacgtggccgagtgccctcacttc
agctcatttgctgacgagctcactgactacaagacaaagaatatgctggccacacccatc
atgaatggcaaagacgtcgtggcggtgatcatggcagtgaacaagctcaacggcccattc
ttcaccagcgaagacgaagatgtgttcttgaagtacctgaattttgccacgttgtacctg
aagatctatcacctgagctacctccacaactgcgagacgcgccgcggccaggtgctgctg
tggtcggccaacaaggtgtttgaggagctgacggacatcgagaggcagttccacaaggcc
ttctacacggtgcgggcctacctcaactgcgagcggtactccgtgggcctcctggacatg
accaaggagaaggaattttttgacgtgtggtctgtgctgatgggagagtcccagccgtac
tcgggcccacgcacgcctgatggccgggaaattgtcttctacaaagtgatcgactacgtc
ctccacggcaaggaggagatcaaggtcattcccacaccctcagccgatcactgggccctg
gccagcggccttccaagctacgtggcagaaagcggctttatttgtaacatcatgaatgct
tccgctgacgaaatgttcaaatttcaggaaggggccctggacgactccgggtggctcatc
aagaatgtgctgtccatgcccatcgtcaacaagaaggaggagattgtgggagtcgccaca
ttttacaacaggaaagacgggaagccctttgacgaacaggacgaggttctcatggagtcc
ctgacacagttcctgggctggtcagtgatgaacaccgacacctacgacaagatgaacaag
ctggagaaccgcaaggacatcgcacaggacatggtcctttaccacgtgaagtgcgacagg
gacgagatccagctcatcctgccaaccagagcgcgcctggggaaggagcctgctgactgc
gatgaggacgagctgggcgaaatcctgaaggaggagctgccagggcccaccacatttgac
atctacgaattccacttctctgacctggagtgcaccgaactggacctggtcaaatgtggc
atccagatgtactacgagctgggcgtggtccgaaagttccagatcccccaggaggtcctg
gtgcggttcctgttctccatcagcaaagggtaccggagaatcacctaccacaactggcgc
cacggcttcaacgtggcccagacgatgttcacgctgctcatgaccggcaaactgaagagc
tactacacggacctggaggccttcgccatggtgacagccggcctgtgccatgacatcgac
caccgcggcaccaacaacctgtaccagatgaagtcccagaaccccttggctaagctccac
ggctcctcgattttggagcggcaccacctggagtttgggaagttcctgctctcggaggag
accctgaacatctaccagaacctgaaccggcggcagcacgagcacgtgatccacctgatg
gacatcgccatcatcgccacggacctggccctgtacttcaagaagagagcgatgtttcag
aagatcgtggatgagtccaagaactaccaggacaagaagagctgggtggagtacctgtcc
ctggagacgacccggaaggagatcgtcatggccatgatgatgacagcctgcgacctgtct
gccatcaccaagccctgggaagtccagagcaaggtcgcacttctcgtggctgctgagttc
tgggagcaaggtgacttggaaaggacagtcttggatcagcagcccattcctatgatggac
cggaacaaggcggccgagctccccaagctgcaagtgggcttcatcgacttcgtgtgcaca
ttcgtgtacaaggagttctctcgtttccacgaagagatcctgcccatgttcgaccgactg
cagaacaataggaaagagtggaaggcgctggctgatgagtatgaggccaaagtgaaggct
ctggaggagaaggaggaggaggagagggtggcagccaagaaagtaggcacagaaatttgc
aatggcggcccagcacccaagtcttcaacctgctgtatcctgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (29)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (21)   
   OC (1)   
Protein sequence (25)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (23)   
DNA sequence (47)   
   RefSeq(nuc) (23)   
   GenBank (12)   
   EMBL (12)   
Protein domain (4)   
   Pfam (4)   
All databases (121)   

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