KEGG   Homo sapiens (human): 5165
Entry
5165              CDS       T01001                                 
Symbol
PDK3, CMTX6, GS1-358P8.4
Name
(RefSeq) pyruvate dehydrogenase kinase 3
  KO
K00898  pyruvate dehydrogenase kinase 2/3/4 [EC:2.7.11.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa05415  Diabetic cardiomyopathy
Disease
H00264  Charcot-Marie-Tooth disease
Drug target
Sodium dichloroacetate: D05857
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09160 Human Diseases
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    5165 (PDK3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5165 (PDK3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.2  [pyruvate dehydrogenase (acetyl-transferring)] kinase
     5165 (PDK3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  PDHK family [OT]
   5165 (PDK3)
SSDB
Motif
Pfam: BCDHK_Adom3 HATPase_c CRM1_C
Other DBs
NCBI-GeneID: 5165
NCBI-ProteinID: NP_005382
OMIM: 300906
HGNC: 8811
Ensembl: ENSG00000067992
UniProt: Q15120
Structure
Position
X:24465286..24550466
AA seq 406 aa
MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANT
MREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHN
DVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVH
PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSH
LFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRL
FNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKA
LSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
NT seq 1221 nt   +upstreamnt  +downstreamnt
atgcggctgttccggtggctgctgaagcagccggtgcccaagcagatcgagcgctactcg
cgcttttcgccgtcgccgctctccatcaaacaattcctggacttcgggagagataatgca
tgtgagaaaacttcatatatgtttctacgaaaggaacttcctgtgcggctggctaacaca
atgagagaagttaatcttctgccggataatttacttaaccgcccttcagtgggattggtt
cagagttggtatatgcagagttttcttgaacttttagaatatgaaaataagagccctgag
gatccacaggtcttggataactttctacaagttctgattaaagtcagaaatagacacaat
gatgtggttcctacaatggcacaaggagtgattgaatacaaggagaagtttgggtttgat
cctttcattagcactaacatccaatattttctggatcggttttataccaaccgcatctct
ttccgcatgcttattaatcagcacacacttctgtttgggggtgacactaatcctgttcat
cctaaacacataggaagtatcgatcccacctgtaacgtggcggatgtggtgaaagatgca
tatgaaacagccaagatgctgtgtgaacagtattacctggtagctccagagctggaagtt
gaagaattcaatgccaaagcgccagacaaacctattcaggtggtttatgtgccctcacat
ctgtttcatatgctatttgagttgttcaagaactcaatgagagcgacagttgaactctat
gaagacagaaaagagggctaccctgctgttaaaaccctcgttactttgggtaaagaagac
ttatccattaagatcagtgacctaggtggtggtgtcccacttcgaaaaatagatcgtctt
tttaactacatgtattctactgctcctagacccagcctggagcctaccagagctgcccct
ttggctggatttggttatggtttgccaatttcccgtctgtatgctagatattttcaagga
gatctgaaactgtattccatggaaggagtgggtactgatgctgtcatttatttgaaggct
ctttcaagtgagtcatttgagagacttccagtttttaataagtccgcatggcgccattac
aagaccacgcctgaagccgatgattggagcaatcccagcagtgaacccagggatgcttca
aaatacaaagcaaaacagtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (15)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (22)   
   RefSeq(nuc) (2)   
   GenBank (10)   
   EMBL (10)   
3D Structure (5)   
   PDB (5)   
Protein domain (3)   
   Pfam (3)   
All databases (59)   

Download RDF
DBGET integrated database retrieval system