KEGG   Homo sapiens (human): 51692
Entry
51692             CDS       T01001                                 
Symbol
CPSF3, CPSF-73, CPSF73, NEDMHS, NEDMHSN
Name
(RefSeq) cleavage and polyadenylation specific factor 3
  KO
K14403  cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03015  mRNA surveillance pathway
Disease
H02461  Neurodevelopmental disorder with microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   03015 mRNA surveillance pathway
    51692 (CPSF3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    51692 (CPSF3)
   03019 Messenger RNA biogenesis [BR:hsa03019]
    51692 (CPSF3)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Other transcription-related factors
    Transcription termination factor
     51692 (CPSF3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    Cleavage and polyadenylation specificity factor (CPSF) complex
     51692 (CPSF3)
    U7-dependent histone pre-mRNA processing factors
     51692 (CPSF3)
SSDB
Motif
Pfam: CPSF73-100_C Beta-Casp Lactamase_B_6 Lactamase_B RMMBL Lactamase_B_2 Lactamase_B_3 Beta_lactamase3
Other DBs
NCBI-GeneID: 51692
NCBI-ProteinID: NP_057291
OMIM: 606029
HGNC: 2326
Ensembl: ENSG00000119203
UniProt: Q9UKF6
Structure
Position
2:9423654..9473101
AA seq 684 aa
MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLID
PAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADD
MLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDF
SRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPV
FALGRAQELLLILDEYWQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININ
NPFVFKHISNLKSMDHFDDIGPSVVMASPGMMQSGLSRELFESWCTDKRNGVIIAGYCVE
GTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGE
QNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKKPEQGQR
VSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFNLLCYQLQKLTGDVEEL
EIQEKPALKVFKNITVIQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQK
VSKKLEMHVYSKRLEIMLQDIFGEDCVSVKDDSILSVTVDGKTANLNLETRTVECEEGSE
DDESLREMVELAAQRLYEALTPVH
NT seq 2055 nt   +upstreamnt  +downstreamnt
atgtctgcgattcctgctgaggagagcgaccagctgctgatccgaccccttggagctggg
caagaagtaggaagatcatgtattattctcgagttcaaaggaagaaaaataatgctcgac
tgtgggatccaccctggcctagaaggaatggatgctcttccttatattgatttaattgac
ccagctgagattgatctcctattaattagtcatttccatttggatcactgtggagctctg
ccctggtttctacagaagacaagtttcaaaggaagaacatttatgactcatgccacaaaa
gctatttatagatggcttctttctgattatgtcaaagttagtaacatatcagcagacgac
atgctgtataccgagacagatttggaagaaagcatggacaaaattgaaactatcaacttt
catgaagttaaggaagttgcgggaatcaagttttggtgttaccatgcaggtcacgtccta
ggagccgccatgttcatgattgagatcgcaggcgtgaagcttttgtacactggtgatttc
tcaagacaagaagataggcacttaatggcagctgaaattcctaatattaagcctgatatt
cttatcattgaatctacttatgggacccatatccatgagaaacgtgaagagcgagaagca
agattctgtaacactgtccacgatattgtaaacagaggaggcaggggtctcattcctgtc
tttgctcttggaagggctcaggagctgctcttgattctagatgagtactggcagaatcac
ccagaactacatgacattccaatatactatgcatcatctttggccaagaagtgtatggca
gtgtaccagacatatgtaaatgccatgaatgacaaaatccgcaaacagatcaacatcaat
aatccctttgttttcaaacacattagtaacctcaagagcatggatcattttgatgacatt
ggtcccagtgttgtaatggcctccccaggcatgatgcaaagtggcttatccagagaatta
tttgaaagctggtgtactgataagaggaatggtgtcattatagcgggatactgtgtagaa
gggacacttgccaagcacatcatgtctgaacctgaagaaatcactactatgtctggacag
aagttaccactgaaaatgtctgttgattacatttctttctcagctcacacggattaccag
caaaccagtgaatttattcgtgctttgaaaccgcctcatgtgattttagtccatggagaa
cagaatgaaatggccagattgaaagcagcactgattcgagaatatgaagataacgatgaa
gttcacatagaggttcataatcctcggaatacagaagcagtgaccttaaacttcagagga
gaaaaactagccaaggttatgggatttttagcagacaaaaaaccagaacaaggccagcgg
gtctcaggaatacttgttaaaagaaactttaattatcacatactttctccttgcgacctg
tccaattatactgacctggccatgagcacggtgaagcagacccaagccattccatatact
ggtccctttaatttgctctgttaccagctgcagaaattgacaggtgatgtggaagaatta
gaaattcaagaaaaacctgctctgaaagtgttcaaaaatattactgtaatacaagaacca
ggcatggtggtattagaatggctggcaaacccttctaatgatatgtatgcagatacagta
acaactgtgatattggaagttcagtcaaatcccaaaataagaaaaggtgcagtacagaag
gtttctaaaaaattagaaatgcacgtttacagcaagaggttggagatcatgctccaggac
atatttggagaagactgtgtaagtgtaaaggatgactctattcttagcgtcacagtggac
gggaaaactgccaaccttaacttggagacacggactgtagaatgtgaagagggaagtgaa
gacgatgaatccctccgagaaatggtggagctggctgcacagagactgtacgaggccctg
acgccagttcactga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (10)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (39)   
   RefSeq(nuc) (7)   
   GenBank (16)   
   EMBL (16)   
3D Structure (6)   
   PDB (6)   
Protein domain (8)   
   Pfam (8)   
All databases (93)   

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