KEGG   Homo sapiens (human): 51733
Entry
51733             CDS       T01001                                 
Symbol
UPB1, BUP1
Name
(RefSeq) beta-ureidopropionase 1
  KO
K01431  beta-ureidopropionase [EC:3.5.1.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00240  Pyrimidine metabolism
hsa00410  beta-Alanine metabolism
hsa00770  Pantothenate and CoA biosynthesis
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
Module
hsa_M00046  Pyrimidine degradation, uracil => beta-alanine, thymine => 3-aminoisobutanoate
Disease
H00200  Beta-ureidopropionase deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    51733 (UPB1)
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    51733 (UPB1)
  09108 Metabolism of cofactors and vitamins
   00770 Pantothenate and CoA biosynthesis
    51733 (UPB1)
  09111 Xenobiotics biodegradation and metabolism
   00983 Drug metabolism - other enzymes
    51733 (UPB1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.6  beta-ureidopropionase
     51733 (UPB1)
SSDB
Motif
Pfam: CN_hydrolase
Other DBs
NCBI-GeneID: 51733
NCBI-ProteinID: NP_057411
OMIM: 606673
HGNC: 16297
Ensembl: ENSG00000100024
UniProt: Q9UBR1 B3KNC1
Structure
Position
22:24495332..24528390
AA seq 384 aa
MAGAEWKSLEECLEKHLPLPDLQEVKRVLYGKELRKLDLPREAFEAASREDFELQGYAFE
AAEEQLRRPRIVHVGLVQNRIPLPANAPVAEQVSALHRRIKAIVEVAAMCGVNIICFQEA
WTMPFAFCTREKLPWTEFAESAEDGPTTRFCQKLAKNHDMVVVSPILERDSEHGDVLWNT
AVVISNSGAVLGKTRKNHIPRVGDFNESTYYMEGNLGHPVFQTQFGRIAVNICYGRHHPL
NWLMYSINGAEIIFNPSATIGALSESLWPIEARNAAIANHCFTCAINRVGTEHFPNEFTS
GDGKKAHQDFGYFYGSSYVAAPDSSRTPGLSRSRDGLLVAKLDLNLCQQVNDVWNFKMTG
RYEMYARELAEAVKSNYSPTIVKE
NT seq 1155 nt   +upstreamnt  +downstreamnt
atggcgggcgctgagtggaagtcgctggaggaatgcttggagaagcacctgccgctcccc
gacttgcaggaagtgaagcgcgttctctatggcaaggaactcaggaagcttgatctgccc
agggaagctttcgaagctgcctccagagaagactttgaactgcagggatatgcctttgaa
gcagcggaggagcagctgagacgaccccgcattgtgcacgtggggctggttcagaacaga
atccccctccccgcaaatgcccctgtggcagaacaggtctctgcccttcatagacgcata
aaggctatcgtagaggtggctgcaatgtgtggagtcaacatcatctgtttccaggaagca
tggactatgccctttgccttctgtacgagagagaagcttccttggacagaatttgctgag
tcagcagaggatgggcccaccaccagattctgtcagaagctggcgaagaaccatgacatg
gtggtggtgtctcccatcctggaacgagacagcgagcatggggatgttttgtggaataca
gccgtggtgatctccaattccggagcagtcctgggaaagaccaggaaaaaccacatcccc
agagtgggtgatttcaacgagtcaacttactacatggagggaaacctgggccaccccgtg
ttccagacgcagttcggaaggatcgcggtgaacatttgctacgggcggcaccaccccctc
aactggcttatgtacagcatcaacggggctgagatcatcttcaacccctcggccacgata
ggagcactcagcgagtccctgtggcccatcgaggccagaaacgcagccattgccaatcac
tgcttcacctgcgccatcaatcgagtgggcaccgagcacttcccgaacgagtttacctcg
ggagatggaaagaaagctcaccaggactttggctacttttatggctcgagctatgtggca
gcccctgacagcagccggactcctgggctgtcccgtagccgggatggactgctagttgct
aagctcgacctaaacctctgccagcaggtgaatgatgtctggaacttcaagatgacgggc
aggtatgagatgtacgcacgggagctcgccgaagctgtcaagtccaactacagccccacc
atcgtgaaagagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (10)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (29)   
   RefSeq(nuc) (9)   
   GenBank (10)   
   EMBL (10)   
3D Structure (1)   
   PDB (1)   
Protein domain (1)   
   Pfam (1)   
All databases (77)   

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