KEGG   Homo sapiens (human): 51780
Entry
51780             CDS       T01001                                 
Symbol
KDM3B, 5qNCA, C5orf7, DIJOS, JMJD1B, NET22
Name
(RefSeq) lysine demethylase 3B
  KO
K15601  [histone H3]-dimethyl-L-lysine9 demethylase [EC:1.14.11.65]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04714  Thermogenesis
Network
nt06529  Thermogenesis
  Element
N01688  ADRB3-UCP1 signaling pathway
Disease
H02521  Diets-Jongmans syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04714 Thermogenesis
    51780 (KDM3B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    51780 (KDM3B)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.65  [histone H3]-dimethyl-L-lysine9 demethylase
     51780 (KDM3B)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    51780 (KDM3B)
SSDB
Motif
Pfam: JmjC Cupin_2 C1_2
Other DBs
NCBI-GeneID: 51780
NCBI-ProteinID: NP_057688
OMIM: 609373
HGNC: 1337
Ensembl: ENSG00000120733
UniProt: Q7LBC6
Structure
Position
5:138352685..138437027
AA seq 1761 aa
MADAAASPVGKRLLLLFADTAASASASAPAAAAASGDPGPALRTRAWRAGTVRAMSGAVP
QDLAIFVEFDGCNWKQHSWVKVHAEEVIVLLLEGSLVWAPREDPVLLQGIRVSIAQWPAL
TFTPLVDKLGLGSVVPVEYLLDRELRFLSDANGLHLFQMGTDSQNQILLEHAALRETVNA
LISDQKLQEIFSRGPYSVQGHRVKIYQPEGEEGWLYGVVSHQDSITRLMEVSVTESGEIK
SVDPRLIHVMLMDNSAPQSEGGTLKAVKSSKGKKKRESIEGKDGRRRKSASDSGCDPASK
KLKGDRGEVDSNGSDGGEASRGPWKGGNASGEPGLDQRAKQPPSTFVPQINRNIRFATYT
KENGRTLVVQDEPVGGDTPASFTPYSTATGQTPLAPEVGGAENKEAGKTLEQVGQGIVAS
AAVVTTASSTPNTVRISDTGLAAGTVPEKQKGSRSQASGENSRNSILASSGFGAPLPSSS
QPLTFGSGRSQSNGVLATENKPLGFSFGCSSAQEAQKDTDLSKNLFFQCMSQTLPTSNYF
TTVSESLADDSSSRDSFKQSLESLSSGLCKGRSVLGTDTKPGSKAGSSVDRKVPAESMPT
LTPAFPRSLLNARTPENHENLFLQPPKLSREEPSNPFLAFVEKVEHSPFSSFASQASGSS
SSATTVTSKVAPSWPESHSSADSASLAKKKPLFITTDSSKLVSGVLGSALTSGGPSLSAM
GNGRSSSPTSSLTQPIEMPTLSSSPTEERPTVGPGQQDNPLLKTFSNVFGRHSGGFLSSP
ADFSQENKAPFEAVKRFSLDERSLACRQDSDSSTNSDLSDLSDSEEQLQAKTGLKGIPEH
LMGKLGPNGERSAELLLGKSKGKQAPKGRPRTAPLKVGQSVLKDVSKVKKLKQSGEPFLQ
DGSCINVAPHLHKCRECRLERYRKFKEQEQDDSTVACRFFHFRRLIFTRKGVLRVEGFLS
PQQSDPDAMNLWIPSSSLAEGIDLETSKYILANVGDQFCQLVMSEKEAMMMVEPHQKVAW
KRAVRGVREMCDVCETTLFNIHWVCRKCGFGVCLDCYRLRKSRPRSETEEMGDEEVFSWL
KCAKGQSHEPENLMPTQIIPGTALYNIGDMVHAARGKWGIKANCPCISRQNKSVLRPAVT
NGMSQLPSINPSASSGNETTFSGGGGPAPVTTPEPDHVPKADSTDIRSEEPLKTDSSASN
SNSELKAIRPPCPDTAPPSSALHWLADLATQKAKEETKEAGSLRSVLNKESHSPFGLDSF
NSTAKVSPLTPKLFNSLLLGPTASNNKTEGSSLRDLLHSGPGKLPQTPLDTGIPFPPVFS
TSSAGVKSKASLPNFLDHIIASVVENKKTSDASKRACNLTDTQKEVKEMVMGLNVLDPHT
SHSWLCDGRLLCLHDPSNKNNWKIFRECWKQGQPVLVSGVHKKLKSELWKPEAFSQEFGD
QDVDLVNCRNCAIISDVKVRDFWDGFEIICKRLRSEDGQPMVLKLKDWPPGEDFRDMMPT
RFEDLMENLPLPEYTKRDGRLNLASRLPSYFVRPDLGPKMYNAYGLITAEDRRVGTTNLH
LDVSDAVNVMVYVGIPIGEGAHDEEVLKTIDEGDADEVTKQRIHDGKEKPGALWHIYAAK
DAEKIRELLRKVGEEQGQENPPDHDPIHDQSWYLDQTLRKRLYEEYGVQGWAIVQFLGDA
VFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFRLTQEFRHLSNTHTNHEDKLQVKNII
YHAVKDAVGTLKAHESKLARS
NT seq 5286 nt   +upstreamnt  +downstreamnt
atggcggacgcggcggcctccccggtgggcaagcggctgctgctgctgttcgcggacact
gcggcctcagcctcggcctcggctcccgcggcggcagcggcgagcggagatccggggcct
gcgctgcgcactcgagcctggcgggccggcacggtgcgggccatgagcggggcggtgccc
caggacctagcgatctttgtagaatttgatggctgtaactggaagcaacactcctgggta
aaagttcatgctgaggaagttatcgtgcttctgctggaagggtctcttgtatgggcgccc
cgtgaggacccagtccttctccagggcattcgagtctccattgcacaatggccagccctg
acttttactccccttgtagataaactgggtttgggttctgtggttccagtggaatatctt
ctggatcgagagcttcggttcctgtcagatgccaatgggttgcatctgtttcagatggga
acagatagccaaaaccagattcttttggaacatgctgcactgagagaaacagttaatgct
ttgatcagtgaccaaaagctacaagagatattcagccgaggtccctacagtgttcaaggt
cacagggtcaaaatatatcagccagagggggaagaagggtggctctatggtgttgtgagc
catcaggactccatcactcgtcttatggaggtgtctgtaactgagagtggtgagatcaag
tcggtagatcccagactaatccatgtgatgctgatggataattcagcgcctcaaagcgag
gggggtacgttaaaagcagtaaaatcttccaaaggaaagaagaagagagaaagcatagag
gggaaagatggccggaggaggaaaagtgcttcggactctgggtgtgaccctgcatcaaag
aaattaaaaggagacaggggtgaagtagacagtaatgggagcgatggaggtgaggcaagc
cgagggccctggaaaggagggaatgccagtggagagccagggctggatcagagagccaag
cagccaccgtctacatttgtcccccagataaaccgcaacattcgctttgccacttacacc
aaagaaaacggcaggactctggtggtgcaggatgagcctgtaggtggggacacacctgca
tctttcactccatattctacagccacaggtcagacacctttggccccagaggtgggtgga
gccgaaaacaaagaggcaggaaaaacactggaacaagttggccagggcatagtggcttcc
gcagctgtggtcactaccgccagctccaccccaaacacagtgaggatctcagacactggc
cttgcagcagggactgtgccagaaaaacagaaaggcagccggtcgcaggcctcgggagag
aattcaagaaattctattctggcctcttctggatttggagcacctctccctagttcatcg
caacctttgacttttggaagtggaaggagccagtccaatggtgttctagccacagagaac
aaacctttgggcttctcttttggctgtagctctgcacaagaggcacagaaagacactgat
ctctccaaaaacttgttttttcaatgcatgtcccaaactttacctaccagtaactacttc
actactgtttcagagagtttggctgatgattcttctagtcgggactcattcaaacaaagc
cttgagagcctgagctcaggcctgtgtaaaggcagatccgttcttggaacagacactaag
ccaggctctaaggctggcagctctgtggaccggaaagtgcctgcagagtccatgcccacc
ctcactccagccttcccacggagcctcctaaatgcccgtaccccagagaatcatgaaaat
ctatttttacagccccccaaattgtcccgagaagagccttctaatcctttcctggcattt
gtggagaaagttgaacacagccctttcagtagttttgcatctcaggcatcaggtagctcc
tcttctgctaccactgtcacctccaaggtggcacccagctggcccgagtctcactcctct
gcagattcggcatctttagcaaagaagaaacccctcttcattacaactgactcctccaag
ctagtatctggtgttctgggctcagctcttaccagtgggggcccaagcctctctgccatg
gggaatggccgctccagctcgcccaccagcagcctcactcagcccattgagatgccaact
ctctcctctagccccacagaggagaggccaactgtggggcctgggcagcaggacaatccc
ctcctcaaaacctttagtaacgtctttggcaggcactcaggcggctttctgtcctccccg
gcagatttttcacaggagaacaaagctccttttgaagctgtgaaaaggttctcactggat
gaacgaagcttggcttgcagacaagactcggactccagcaccaacagtgacctgtcagat
ttgagtgactctgaggagcagctgcaggctaagacaggcctgaagggaattccagagcac
ctgatggggaagctgggccccaatggggagcgcagtgctgagctgttgctgggcaaaagc
aaagggaagcaggcccccaagggccggcctcggactgcccccctgaaagttggccagtca
gtgctgaaagatgtaagcaaagtgaagaagctgaagcaatctggagagcccttcctgcag
gatgggtcatgcatcaatgtggcacctcatctgcacaagtgtcgtgaatgccgcctggag
cggtaccggaagtttaaggaacaggagcaagatgattctactgtagcctgccgtttcttt
cacttccggaggttgatcttcactcgaaaaggggtactccgtgtggaggggtttttaagc
ccccagcaaagtgaccctgatgccatgaacctgtggattccctcttcctccctagcagaa
gggatagatctagagacctcaaaatacatcctggccaatgttggggaccagttctgccag
ctcgtaatgtctgagaaggaggccatgatgatggtggagccacaccagaaagtggcatgg
aagcgagctgtgcgtggtgtacgggagatgtgtgatgtgtgtgaaacaactctcttcaac
atccactgggtttgtcgcaaatgtggatttggggtctgccttgactgttaccggctcagg
aaaagccggccacgcagtgagacagaagagatgggtgatgaagaagttttctcctggttg
aagtgtgcaaagggacagtcccacgaaccagagaatctcatgcccacacaaattattcct
ggcacagctctttacaatattggagacatggtacatgctgcccggggcaagtggggaatt
aaagcaaactgcccttgtatcagtcgacagaacaaatctgtattgagacctgccgtcacc
aatgggatgtcacagcttcctagcataaaccctagtgcctcttctggaaacgaaactacc
ttctctggtggaggaggaccggcaccagtaacaactccagagccggaccatgttcccaaa
gccgacagcactgacatcagatctgaagagcctctgaaaacagacagttcggcatcaaat
agcaatagtgaactgaaagccatcaggcctccttgccctgacacggccccaccctcctcc
gccctgcactggttggcagatttagcaactcagaaggctaaagaagaaacaaaagaagca
gggtccctgaggtcggtgctcaataaagagtctcattcaccctttgggctggactcgttc
aactccactgcaaaggtctctccgctgactccaaagctttttaacagtctgttgctgggt
cccactgcctccaacaacaaaaccgaagggtctagccttcgagacctccttcactccggg
ccgggaaaacttcctcaaacccccttggacacaggcataccctttcccccggtcttctct
acatcctcagcaggagtgaagagcaaggccagcctacccaactttcttgaccacatcatt
gcctcagtggtagaaaataagaaaacctcagatgcttcaaagcgggcctgcaacttgact
gatacccagaaggaagtgaaggagatggtgatggggttaaatgtgctagatccccatact
tctcactcctggctttgtgatgggaggcttctgtgtctccatgaccccagcaacaaaaac
aattggaagatcttccgggagtgttggaagcaaggtcagccagtgctggtttcgggggta
cataaaaagctcaagtctgagctctggaagccagaagcctttagccaggaatttggagac
caggatgtagacttggtgaactgcaggaactgtgctataatttccgatgtgaaagttcgg
gatttctgggatggtttcgagatcatatgcaaacgactacggtcagaagatgggcagcca
atggtgctcaaactcaaggactggcctcctggggaagattttcgagacatgatgccaacc
aggtttgaagatctgatggagaaccttcctctgccagaatataccaaacgagatggcagg
ctcaatctggcctctaggctacctagctactttgtaaggcctgatctgggccccaagatg
tacaacgcctatgggttgataacagcagaagatagaagagttggtacaacaaatcttcac
ttagatgtgtctgatgctgttaatgtgatggtgtatgttgggattcccatcggggagggt
gctcatgatgaagaggtactcaagacaattgacgagggagatgccgatgaggtgacgaag
cagaggattcatgatggaaaagagaagccaggtgctttatggcacatctatgcagccaag
gatgcagagaagatccgggagctgctccgaaaggttggagaagaacaaggccaagagaac
ccccctgatcatgacccaattcatgaccaaagttggtacctggaccagaccctccgtaag
cgactctatgaggagtatggcgtgcaaggctgggctattgtgcagttcctaggtgatgct
gttttcatacctgctggagccccacaccaggttcacaatctatacagttgcataaaagta
gcagaagactttgtatctccagaacatgtaaagcactgtttccgcctgactcaggaattc
aggcatctctctaacactcatacaaatcatgaggataaactgcaggtgaagaacatcatt
taccatgcagtgaaagatgcggttggcaccctcaaggctcatgaatccaaactggcaagg
tcctag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (26)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (13)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (11)   
DNA sequence (43)   
   RefSeq(nuc) (11)   
   GenBank (16)   
   EMBL (16)   
3D Structure (36)   
   PDB (36)   
Protein domain (3)   
   Pfam (3)   
All databases (132)   

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