KEGG T01001: 5207

Homo sapiens (human): 5207

Entry

5207              CDS       T01001

Symbol

PFKFB1, F6PK, HL2K, PFRX

Name

(RefSeq) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

K19028

6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 [EC:2.7.1.105 3.1.3.46]

Organism

hsa Homo sapiens (human)

Pathway

hsa00051

Fructose and mannose metabolism

hsa01100

Metabolic pathways

hsa04152

AMPK signaling pathway

hsa04922

Glucagon signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    5207 (PFKFB1)
09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    5207 (PFKFB1)
09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    5207 (PFKFB1)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.105  6-phosphofructo-2-kinase
     5207 (PFKFB1)
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.46  fructose-2,6-bisphosphate 2-phosphatase
     5207 (PFKFB1)

SSDB

Motif

Pfam:

6PF2K His_Phos_1 AAA_33 KTI12 Zeta_toxin Arf

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

X:complement(54932961..54998789)

AA seq 471 aa
MSPEMGELTQTRLQKIWIPHSSGSSRLQRRRGSSIPQFTNSPTMVIMVGLPARGKTYIST
KLTRYLNWIGTPTKVFNLGQYRREAVSYKNYEFFLPDNMEALQIRKQCALAALKDVHNYL
SHEEGHVAVFDATNTTRERRSLILQFAKEHGYKVFFIESICNDPGIIAENIRQVKLGSPD
YIDCDREKVLEDFLKRIECYEVNYQPLDEELDSHLSYIKIFDVGTRYMVNRVQDHIQSRT
VYYLMNIHVTPRSIYLCRHGESELNIRGRIGGDSGLSVRGKQYAYALANFIQSQGISSLK
VWTSHMKRTIQTAEALGVPYEQWKALNEIDAGVCEEMTYEEIQEHYPEEFALRDQDKYRY
RYPKGESYEDLVQRLEPVIMELERQENVLVICHQAVMRCLLAYFLDKSSDELPYLKCPLH
TVLKLTPVAYGCKVESIYLNVEAVNTHREKPENVDITREPEEALDTVPAHY

NT seq 1416 nt +upstreamnt +downstreamnt
atgtctccagagatgggagagctcacccaaaccaggttgcagaagatctggattccacac
agcagcggcagcagcaggctgcaacggagaaggggctcatccataccccagtttaccaat
tcccccacaatggtgatcatggtgggtttaccagctcgaggcaagacctatatctccaca
aagctcacacgatatctcaactggataggaacaccaactaaagtgtttaatttaggccag
tatcgacgagaggcagtgagctacaagaactatgaattctttcttccagacaacatggaa
gccctgcaaatcaggaagcagtgcgccctggcagccctgaaggatgttcacaactatctc
agccatgaggaaggtcatgttgcggtttttgatgccaccaacactaccagagaacgacgg
tcactgatcctgcagtttgcaaaagaacatggttacaaggtgtttttcattgagtccatt
tgtaatgaccctggcataattgcagaaaacatcaggcaagtgaaacttggcagccctgat
tatatagactgtgaccgggaaaaggttctggaagactttctaaagagaattgagtgctat
gaggtcaactaccaacccttggatgaggaactggacagccacctgtcctacatcaagatc
ttcgacgtgggcacacgctacatggtgaaccgagtgcaggatcacatccagagccgcaca
gtctactacctcatgaatatccatgtcacacctcgctccatctacctttgccgacatggc
gagagtgaactcaacatcagaggccgcatcggaggtgactctggcctctcagttcgcggc
aagcagtatgcctatgccctggccaacttcattcagtcccagggcatcagctccctgaag
gtgtggaccagtcacatgaagaggaccatccagacagctgaggccctgggtgtcccctat
gagcagtggaaggccctgaatgagattgatgcgggtgtctgtgaggagatgacctatgaa
gaaatccaggaacattaccctgaagaatttgcactgcgagaccaagataaatatcgctac
cgctatcccaagggagagtcctatgaggatctggttcagcgtctggagccagtgataatg
gagctagaacgacaggagaatgtactggtgatctgccaccaggctgtcatgcggtgcctc
ctggcctatttcctggataaaagttcagatgagcttccatatctcaagtgccctctgcac
acagtgctcaaactcactcctgtggcttatggctgcaaagtggaatccatctacctgaat
gtggaggccgtgaacacacaccgggagaagcctgagaatgtggacatcacccgggaacct
gaggaagccctggatactgtcccagcccactactga

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