KEGG   Homo sapiens (human): 5209
Entry
5209              CDS       T01001                                 
Symbol
PFKFB3, IPFK2, PFK2, iPFK-2
Name
(RefSeq) 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  KO
K01103  6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3 [EC:2.7.1.105 3.1.3.46]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00051  Fructose and mannose metabolism
hsa01100  Metabolic pathways
hsa04066  HIF-1 signaling pathway
hsa04152  AMPK signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    5209 (PFKFB3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    5209 (PFKFB3)
   04152 AMPK signaling pathway
    5209 (PFKFB3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.105  6-phosphofructo-2-kinase
     5209 (PFKFB3)
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.46  fructose-2,6-bisphosphate 2-phosphatase
     5209 (PFKFB3)
SSDB
Motif
Pfam: 6PF2K His_Phos_1 AAA_33 KTI12 Zeta_toxin DIL AAA_17 SRP54 AAA_18
Other DBs
NCBI-GeneID: 5209
NCBI-ProteinID: NP_004557
OMIM: 605319
HGNC: 8874
Ensembl: ENSG00000170525
UniProt: Q16875
Structure
Position
10:6144921..6326637
AA seq 520 aa
MPLELTQSRVQKIWVPVDHRPSLPRSCGPKLTNSPTVIVMVGLPARGKTYISKKLTRYLN
WIGVPTKVFNVGEYRREAVKQYSSYNFFRPDNEEAMKVRKQCALAALRDVKSYLAKEGGQ
IAVFDATNTTRERRHMILHFAKENDFKAFFIESVCDDPTVVASNIMEVKISSPDYKDCNS
AEAMDDFMKRISCYEASYQPLDPDKCDRDLSLIKVIDVGRRFLVNRVQDHIQSRIVYYLM
NIHVQPRTIYLCRHGENEHNLQGRIGGDSGLSSRGKKFASALSKFVEEQNLKDLRVWTSQ
LKSTIQTAEALRLPYEQWKALNEIDAGVCEELTYEEIRDTYPEEYALREQDKYYYRYPTG
ESYQDLVQRLEPVIMELERQENVLVICHQAVLRCLLAYFLDKSAEEMPYLKCPLHTVLKL
TPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFE
EHVASTSAALPSCLPPEVPTQLPGQNMKGSRSSADSSRKH
NT seq 1563 nt   +upstreamnt  +downstreamnt
atgccgttggaactgacgcagagccgagtgcagaagatctgggtgcccgtggaccacagg
ccctcgttgcccagatcctgtgggccaaagctgaccaactcccccaccgtcatcgtcatg
gtgggcctccccgcccggggcaagacctacatctccaagaagctgactcgctacctcaac
tggattggcgtccccacaaaagtgttcaacgtcggggagtatcgccgggaggctgtgaag
cagtacagctcctacaacttcttccgccccgacaatgaggaagccatgaaagtccggaag
caatgtgccttagctgccttgagagatgtcaaaagctacctggcgaaagaagggggacaa
attgcggttttcgatgccaccaatactactagagagaggagacacatgatccttcatttt
gccaaagaaaatgactttaaggcgtttttcatcgagtcggtgtgcgacgaccctacagtt
gtggcctccaatatcatggaagttaaaatctccagcccggattacaaagactgcaactcg
gcagaagccatggacgacttcatgaagaggatcagttgctatgaagccagctaccagccc
ctcgaccccgacaaatgcgacagggacttgtcgctgatcaaggtgattgacgtgggccgg
aggttcctggtgaaccgggtgcaggaccacatccagagccgcatcgtgtactacctgatg
aacatccacgtgcagccgcgtaccatctacctgtgccggcacggcgagaacgagcacaac
ctccagggccgcatcgggggcgactcaggcctgtccagccggggcaagaagtttgccagt
gctctgagcaagttcgtggaggagcagaacctgaaggacctgcgcgtgtggaccagccag
ctgaagagcaccatccagacggccgaggcgctgcggctgccctacgagcagtggaaggcg
ctcaatgagatcgacgcgggcgtctgtgaggagctgacctacgaggagatcagggacacc
taccctgaggagtatgcgctgcgggagcaggacaagtactattaccgctaccccaccggg
gagtcctaccaggacctggtccagcgcttggagccagtgatcatggagctggagcggcag
gagaatgtgctggtcatctgccaccaggccgtcctgcgctgcctgcttgcctacttcctg
gataagagtgcagaggagatgccctacctgaaatgccctcttcacaccgtcctgaaactg
acgcctgtcgcttatggctgccgtgtggaatccatctacctgaacgtggagtccgtctgc
acacaccgggagaggtcagaggatgcaaagaagggacctaacccgctcatgagacgcaat
agtgtcaccccgctagccagccccgaacccaccaaaaagcctcgcatcaacagctttgag
gagcatgtggcctccacctcggccgccctgcccagctgcctgcccccggaggtgcccacg
cagctgcctggacaaaacatgaaaggctcccggagcagcgctgactcctccaggaaacac
tga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
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   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (31)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (29)   
DNA sequence (78)   
   RefSeq(nuc) (30)   
   GenBank (24)   
   EMBL (24)   
3D Structure (26)   
   PDB (26)   
Protein domain (9)   
   Pfam (9)   
All databases (185)   

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