KEGG   Homo sapiens (human): 5226
Entry
5226              CDS       T01001                                 
Symbol
PGD, 6PGD
Name
(RefSeq) phosphogluconate dehydrogenase
  KO
K00033  6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00030  Pentose phosphate pathway
hsa00480  Glutathione metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
Module
hsa_M00004  Pentose phosphate pathway (Pentose phosphate cycle)
hsa_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P
Network
nt06026  Glutathione biosynthesis
  Element
N00905  NADP+ reduction
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    5226 (PGD)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    5226 (PGD)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.44  phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)
     5226 (PGD)
    1.1.1.343  phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating)
     5226 (PGD)
SSDB
Motif
Pfam: 6PGD NAD_binding_2 F420_oxidored NAD_binding_11
Other DBs
NCBI-GeneID: 5226
NCBI-ProteinID: NP_002622
OMIM: 172200
HGNC: 8891
Ensembl: ENSG00000142657
UniProt: P52209
Structure
Position
1:10399064..10420511
AA seq 483 aa
MAQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVVGAQSLKE
MVSKLKKPRRIILLVKAGQAVDDFIEKLVPLLDTGDIIIDGGNSEYRDTTRRCRDLKAKG
ILFVGSGVSGGEEGARYGPSLMPGGNKEAWPHIKTIFQGIAAKVGTGEPCCDWVGDEGAG
HFVKMVHNGIEYGDMQLICEAYHLMKDVLGMAQDEMAQAFEDWNKTELDSFLIEITANIL
KFQDTDGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQA
SKKLKGPQKFQFDGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIAL
MWRGGCIIRSVFLGKIKDAFDRNPELQNLLLDDFFKSAVENCQDSWRRAVSTGVQAGIPM
PCFTTALSFYDGYRHEMLPASLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSS
YNA
NT seq 1452 nt   +upstreamnt  +downstreamnt
atggcccaagctgacatcgcgctgatcggattggccgtcatgggccagaacttaattctg
aacatgaatgaccacggctttgtggtctgtgcttttaataggactgtctccaaagttgat
gatttcttggccaatgaggcaaagggaaccaaagtggtgggtgcccagtccctgaaagag
atggtctccaagctgaagaagccccggcggatcatcctcctggtgaaggctgggcaagct
gtggatgatttcatcgagaaattggtaccattgttggatactggtgacatcatcattgac
ggaggaaattctgaatatagggacaccacaagacggtgccgagacctcaaggccaaggga
attttatttgtggggagcggagtcagtggtggagaggaaggggcccggtatggcccatcg
ctcatgccaggagggaacaaagaagcgtggccccacatcaagaccatcttccaaggcatt
gctgcaaaagtgggaactggagaaccctgctgtgactgggtgggagatgagggagcaggc
cacttcgtgaagatggtgcacaacgggatagagtatggggacatgcagctgatctgtgag
gcataccacctgatgaaagacgtgctgggcatggcgcaggacgagatggcccaggccttt
gaggattggaataagacagagctagactcattcctgattgaaatcacagccaatattctc
aagttccaagacaccgatggcaaacacctgctgccaaagatcagggacagcgcggggcag
aagggcacagggaagtggaccgccatctccgccctggaatacggcgtacccgtcaccctc
attggagaagctgtctttgctcggtgcttatcatctctgaaggatgagagaattcaagct
agcaaaaagctgaagggtccccagaagttccagtttgatggtgataagaaatcattcctg
gaggacattcggaaggcactctacgcttccaagatcatctcttacgctcaaggctttatg
ctgctaaggcaggcagccaccgagtttggctggactctcaattatggtggcatcgccctg
atgtggagagggggctgcatcattagaagtgtattcctaggaaagataaaggatgcattt
gatcgaaacccggaacttcagaacctcctactggacgacttctttaagtcagctgttgaa
aactgccaggactcctggcggcgggcagtcagcactggggtccaggctggcattcccatg
ccctgttttaccactgccctctccttctatgacgggtacagacatgagatgcttccagcc
agcctcatccaggctcagcgggattacttcggggctcacacctatgaactcttggccaaa
ccagggcagtttatccacaccaactggacaggccatggtggcaccgtgtcatcctcgtca
tacaatgcctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (4)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (34)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
3D Structure (4)   
   PDB (4)   
Protein domain (4)   
   Pfam (4)   
All databases (106)   

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