KEGG   Homo sapiens (human): 5297
Entry
5297              CDS       T01001                                 
Symbol
PI4KA, GIDID2, PI4K-ALPHA, PIK4CA, PMGYCHA, SPG84, pi4K230
Name
(RefSeq) phosphatidylinositol 4-kinase alpha
  KO
K00888  phosphatidylinositol 4-kinase A [EC:2.7.1.67]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00562  Inositol phosphate metabolism
hsa01100  Metabolic pathways
hsa04070  Phosphatidylinositol signaling system
Module
hsa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Disease
H00266  Hereditary spastic paraplegia
H00271  Polymicrogyria
H02331  Gastrointestinal defects and immunodeficiency syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    5297 (PI4KA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    5297 (PI4KA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    5297 (PI4KA)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.67  1-phosphatidylinositol 4-kinase
     5297 (PI4KA)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Others
   EFR3-PI4KIII alpha complex and associated proteins
    5297 (PI4KA)
 Endosome - Golgi transport
   Others
    5297 (PI4KA)
SSDB
Motif
Pfam: PI4K_N PI3_PI4_kinase PI3Ka ABC1 PI4KB-PIK1_PIK
Other DBs
NCBI-GeneID: 5297
NCBI-ProteinID: NP_477352
OMIM: 600286
HGNC: 8983
Ensembl: ENSG00000241973
UniProt: P42356 Q4LE69 B4DYG5
Structure
Position
22:complement(20707691..20858811)
AA seq 2102 aa
MAAAPARGGGGGGGGGGGCSGSGSSASRGFYFNTVLSLARSLAVQRPASLEKVQKLLCMC
PVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCVVPYLLRLLKGLPKVYWVEESTARK
GRGALPVAESFSFCLVTLLSDVAYRDPSLRDEILEVLLQVLHVLLGMCQALEIQDKEYLC
KYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRVLEELEGVRRRSFNDFRSILPS
NLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTALEPEYY
FSTISSSFSVSPLFNGVTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANP
SADLYYTSFSDPLYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHD
ADRIHNELSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAHLP
LLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGNDIKISV
TNEHSESTLNVMSGKKSQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNRLY
ISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVLIIDQL
GCLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANI
QDEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRR
LPPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEP
LRSVLQYNSAMKNDTVTPAELSELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLE
YMRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKEN
EEELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLS
LSADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHL
QEYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGATQLSERPACVKKDYSNFM
ASLNLRNRYAGEVYGMIRFSGTTGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAML
ISSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFMREMAGAWHMTV
EQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIF
SSLLQRSMSLNIGGAKGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYS
TAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDI
TVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEI
ERLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPA
RFKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTG
LSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKS
QLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLDQLVEEITGSLSGPAKDFYQREFDFFNK
ITNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAK
APYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFKVGDDCRQDML
ALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYF
TRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMF
ESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTL
MLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQNDI
PY
NT seq 6309 nt   +upstreamnt  +downstreamnt
atggcggcggccccggcccggggaggcggaggcggaggcggaggcggcggcggctgctcc
ggctccggctccagcgcctcgcggggcttctatttcaacacggtcctgtcactggcccgc
tccctggcggtgcagagaccagcatccttggagaaggtccaaaagcttctttgcatgtgt
ccagtggatttccatgggatcttccagttagatgaaagacggagagatgcagtgattgca
ttgggcatttttctgattgaatctgatcttcagcacaaagattgtgtggttccttacctt
cttcgacttctcaaaggtcttccaaaagtgtattgggtagaagaaagcacagctcggaaa
ggcagaggtgccctcccggttgcagagagcttcagcttctgcttggtaactctgctgtct
gatgtggcctatagggatccttcacttagggatgagattttagaggtgcttttgcaggtt
ttgcatgtcctcttggggatgtgccaggccttggagattcaagacaaagaatacctttgc
aagtatgctatcccatgcctgataggaatctcgcgagcatttgggcgttacagcaacatg
gaagagtctctcctctcaaagctctttcccaaaatccctcctcattccctccgtgtcctg
gaagagcttgaaggtgttcgaaggcgttcctttaatgacttccgctccatcctccccagc
aatctgctgactgtctgtcaggagggtaccctgaagaggaaaaccagcagtgtgtccagc
atctctcaggtcagccctgaacgcggcatgccccctcccagttcccctggaggatctgcc
tttcactactttgaagcctcctgcttgcccgatgggactgccctagagcctgagtactac
ttttcaaccatcagctccagcttctcagtctctccccttttcaacggtgtcacatataag
gagtttaacattccattggaaatgcttcgggaactcttaaacctggtgaagaagatcgtt
gaggaggctgttctcaaatctttggatgccattgtagccagtgtgatggaggccaacccc
agtgctgatctctactacacttccttcagtgaccctctctacctgaccatgttcaagatg
ctgcgtgacactctgtactacatgaaggacctcccgacctcttttgtgaaggagatccat
gattttgtgctggagcagttcaacacgagccagggggagctccagaagattctacatgac
gcagaccggatccacaatgagctgagccccctcaaactgcgctgtcaggcgaatgctgcc
tgtgtggacctcatggtgtgggctgtgaaggacgagcagggtgcagaaaacctttgcatc
aagctatctgagaagctgcagtccaagacgtccagcaaagtcattattgctcacttgccc
ctgctgatctgctgtctgcagggtttgggccgcctgtgcgagaggttcccggtggtggtg
cactctgtgacaccgtccttgcgagacttcctggtcatcccgtccccagttctggtgaag
ctctacaagtaccacagtcagtaccacacagttgctggcaatgatataaaaatcagtgtg
accaatgagcattccgagtcaaccctgaacgtcatgtcgggtaagaagagccagccctcc
atgtacgagcagctccgagacatcgctattgacaacatctgcaggtgcctgaaggctgga
ttgacggtggacccagtgattgtggaggcgttcttggccagcctgtccaaccggctctac
atctctcaggagagcgacaaggacgctcacttgattcccgaccacacaatccgagccttg
ggacacattgcggtggccttgagggacaccccgaaggtcatggagcccattctgcagatc
ctacagcagaaattctgccagccaccctcccccctcgatgtgctgattattgaccagctg
ggctgcctggttatcaccggaaatcaatacatctatcaggaagtgtggaacctcttccag
cagatcagtgtgaaggccagctccgttgtatactcagccaccaaagattacaaggaccac
ggctataggcattgctccctggcagtgattaatgccctggccaacatcgcggccaacatc
caagacgagcacctggtggatgagctgctcatgaacctgttggagttgtttgtgcagctg
gggctggaggggaagcgagccagcgagagggcaagcgagaagggccctgccctaaaggct
tctagcagtgcagggaacttgggagtactcattcctgtaatagctgtgctcacccgacga
ctgccacccatcaaagaagctaagcctcggttacagaagctcttccgagacttctggctg
tattccgttctgatgggattcgctgtggagggctcaggactctggccagaagaatggtac
gagggggtctgtgaaatagccactaagtcccccttgctcacctttcccagcaaggagcca
ctgcggtccgtcctccagtataactcagccatgaagaatgacacggtcacccccgctgag
ctgagtgagctccgcagcactatcatcaacctgctggacccccctcccgaggtgtccgca
ctcatcaacaagctggacttcgccatgtccacctacctcctctctgtgtaccggctggag
tacatgagggtactgcgttcaacagatcctgatcgcttccaggtaatgttctgctacttt
gaggataaagctattcagaaagacaaatctgggatgatgcagtgtgtgattgcagtcgcg
gacaaagtattcgatgccttcctgaacatgatggcggataaagccaagaccaaggagaac
gaggaggagctggagcggcacgctcagttcctgttggtgaacttcaaccacatccacaag
aggataaggagggtggcagacaagtatctatctggtctggtggataagtttccccacttg
ctctggagcgggactgtgctgaagaccatgctggacatcctgcagaccctgtcactgtca
ctgagcgctgatattcacaaggatcagccttactatgacatccccgacgccccctaccgg
atcacggttcctgacacgtacgaagcccgtgagagcattgtgaaggacttcgctgcacgc
tgtgggatgatcctccaggaggccatgaagtgggcacctaccgtcaccaagtcccacctg
caggaatatctgaacaaacatcagaactgggtatcgggactgtcccagcacacggggctg
gccatggccactgagagcatccttcactttgctggctacaacaagcagaacacaactctt
ggggcaactcagctgagcgagcgcccggcctgtgtgaagaaagactactccaacttcatg
gcatccctgaatctgcgcaaccgctacgcgggcgaggtgtatggaatgattcggttctca
ggcaccacaggccagatgtctgacctgaacaaaatgatggtccaggatctacattcagct
ttagaccgcagtcatcctcagcactacacgcaggccatgttcaagctgaccgcaatgctc
attagcagtaaagattgtgacccgcagctccttcatcatctgtgctggggtcccctccgg
atgttcaatgagcatggcatggagacggccctggcctgctgggagtggctgctggctggc
aaggatggagtggaagtgccgttcatgcgggagatggcaggggcctggcacatgacggtg
gagcagaaatttggcctgttttctgctgagataaaggaagcagaccccctggctgcctcg
gaagcaagtcaacccaaaccctgtccccccgaagtgaccccccactacatctggatcgac
ttcctggtgcagcggtttgagatcgccaagtactgcagctctgaccaagtggagatcttc
tccagcctgctgcagcgctccatgtccctgaacatcggcggggccaaggggagcatgaac
cggcacgtggcggccatcgggccccgcttcaagctgctgaccctggggctgtccctcctg
catgccgatgtggttccaaatgcaaccatccgcaatgtgcttcgcgagaagatctactcc
actgcctttgactacttcagctgtcccccaaagttccctactcaaggagagaagcggctg
cgtgaagacataagcatcatgattaaattttggaccgccatgttctcagataagaagtac
ctgaccgccagccagcttgttcccccagataatcaggacacccggagcaacctggacata
actgtcggctctcggcaacaagccacccaaggctggatcaacacataccccctgtccagc
ggcatgtccaccatctccaagaaatcaggcatgtctaagaaaaccaaccggggctcccag
ctgcacaaatactacatgaagcgcaggacgctgctgctgtccctgctggccactgagatc
gagcgtctcatcacatggtacaacccgctgtcagccccggaactggaactagaccaggcc
ggagagaacagcgtggccaactggagatctaagtacatcagcctgagtgagaagcagtgg
aaggacaacgtgaacctcgcctggagcatctctccctacctagccgtgcagctgcctgcc
aggtttaagaacacagaagccattgggaacgaagtgacccgtctcgttcggttggacccg
ggagccgttagtgatgtgcctgaagcaatcaagttcctggtcacctggcacaccatcgac
gccgatgctccagagctcagccatgtgctgtgctgggcgcccacggacccacccacaggc
ctctcctacttctccagcatgtacccgccgcaccctctcacggcgcagtacggggtgaaa
gtcctgcggtccttccctccggacgccatcctcttctacatcccccagattgtgcaggcc
ctcaggtacgacaagatgggctatgtgcgggagtatattctgtgggcagcgtctaaatcc
cagcttctggcacaccagttcatctggaacatgaagactaacatttatctagatgaagag
ggccaccagaaagaccctgacatcggcgacctcctggatcagttggtagaggagatcaca
ggctccttgtccggcccagcgaaggacttttaccagcgggagtttgatttctttaacaag
atcaccaacgtgtcggctatcatcaagccctaccctaaaggcgacgagagaaagaaggct
tgtctgtcggccctgtctgaagtgaaggtgcagccgggctgctacctgcccagcaaccct
gaggccattgtgctggacatcgactacaagtctgggaccccgatgcagagtgctgcaaaa
gccccatatctggccaagttcaaggtgaagcgatgtggagttagtgaacttgaaaaagaa
ggtctgcggtgccgctcagactccgaggatgagtgcagcacgcaggaggccgacggccag
aagatctcctggcaggcagccatcttcaaggtgggagacgactgccggcaggacatgctg
gccctgcagatcatcgacctcttcaagaacatcttccagctggtcggcctggacctcttt
gtttttccctaccgcgtggtggccactgcccctgggtgcggggtgatcgagtgcatcccc
gactgcacctcccgggaccagctgggccgccagacagacttcggcatgtacgactacttc
acacgccagtacggggatgagtccactctggccttccagcaggcccgctacaacttcatc
cgaagcatggccgcctacagcctcctgctgttcctgctgcagatcaaggacagacacaac
ggcaacattatgctggacaagaagggtcatatcatccacatcgactttggcttcatgttt
gaaagctcgccgggcggcaatctcggctgggaacccgacatcaagctgacggatgagatg
gtgatgatcatggggggcaagatggaggccacacccttcaagtggttcatggagatgtgt
gtccgaggctacctggctgtgcggccctacatggacgcggtcgtctccctggtcactctc
atgttggacacgggcctgccctgttttcgcggccagacaatcaagctcttgaagcacagg
tttagccccaacatgactgagcgcgaggctgcaaatttcatcatgaaggtcatccagagc
tgcttcctcagcaacaggagccggacctacgacatgatccagtactatcagaatgacatc
ccctactga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Disease (7)   
   KEGG DISEASE (3)   
   OMIM (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
Protein sequence (20)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (16)   
DNA sequence (49)   
   RefSeq(nuc) (17)   
   GenBank (16)   
   EMBL (16)   
3D Structure (1)   
   PDB (1)   
Protein domain (5)   
   Pfam (5)   
All databases (120)   

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