KEGG   Homo sapiens (human): 53630
Entry
53630             CDS       T01001                                 
Symbol
BCO1, BCDO, BCDO1, BCMO, BCMO1, BCO
Name
(RefSeq) beta-carotene oxygenase 1
  KO
K00515  beta-carotene 15,15'-dioxygenase [EC:1.13.11.63]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00830  Retinol metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Disease
H01266  Hypercarotenemia and vitamin A deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    53630 (BCO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.63  beta-carotene 15,15'-dioxygenase
     53630 (BCO1)
SSDB
Motif
Pfam: RPE65 DUF4096
Other DBs
NCBI-GeneID: 53630
NCBI-ProteinID: NP_059125
OMIM: 605748
HGNC: 13815
Ensembl: ENSG00000135697
UniProt: Q9HAY6
Position
16:81238689..81291142
AA seq 547 aa
MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSF
TIRDGEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDF
TDNCLINIMKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGN
VLNMGTSIVEKGKTKYVIFKIPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFG
VTENYVIFLEQPFRLDILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFY
TDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFA
VPLHVDKNAEVGTNLIKVASTTATALKEEDGQVYCQPEFLYEGLELPRVNYAHNGKQYRY
VFATGVQWSPIPTKIIKYDILTKSSLKWREDDCWPAEPLFVPAPGAKDEDDGVILSAIVS
TDPQKLPFLLILDAKSFTELARASVDVDMHMDLHGLFITDMDWDTKKQAASEEQRDRASD
CHGAPLT
NT seq 1644 nt   +upstreamnt  +downstreamnt
atggatataatatttggcaggaataggaaagaacagctggagcctgtgagggccaaagtg
acaggcaagattccagcatggctgcagggaaccctgctccgcaatgggcctgggatgcac
acagttggggagtccagatacaaccattggttcgacggccttgccctgctccacagcttc
accatcagagacggtgaagtctattacaggagcaaatacctgagaagcgatacctacaac
accaatattgaggcaaacaggattgtggtgtctgagtttggaacaatggcctatccggac
ccctgcaaaaacatattttccaaagctttctcctacttgtctcacaccatccccgatttc
accgacaactgcctgatcaacatcatgaagtgcggagaagacttctacgcgacctcagag
accaattacatcaggaaaatcaacccacagactctggaaaccctggagaaggttgattat
cgtaaatacgtggcggtaaatctggcaacgtcacatccccattatgatgaggctggaaat
gttctaaacatgggcacatccattgtggaaaaggggaagacaaagtatgtgatttttaag
atccctgccacagtaccagagggcaagaagcaggggaagagcccctggaagcacacagag
gtgttctgctccatcccatcccgctccctgctctccccaagctactaccacagctttgga
gtcaccgagaactatgtcatcttccttgagcagcctttcaggttggatattctcaagatg
gcaaccgcatacatccggagaatgagctgggcctcctgcctggctttccacagggaggag
aagacttatatccacatcatcgaccaaaggaccaggcagcctgtgcagaccaagttttac
acagacgccatggtggtcttccatcacgtcaacgcctacgaagaggacggctgcatcgtg
tttgacgtcattgcctacgaggacaacagcctctaccagctcttctacctggccaacctg
aaccaggacttcaaggagaactccaggctcacctcggtccccaccctcaggaggtttgcc
gtgcccctccacgtggacaagaatgcagaagtgggcacaaatttaatcaaagtggcatct
acaacagccacggccctgaaggaagaagatggccaagtctactgccagccggaatttctt
tatgaaggcttagagcttccacgggtcaattatgctcacaatggaaagcaataccgatat
gtctttgctacaggagttcagtggagtccaatcccaaccaagataataaaatatgacatt
ctcacaaagtcatccttaaaatggagagaggacgactgctggccagcggaacccctgttt
gtgcccgcgccaggtgccaaggatgaggatgacggagtaatcttatcagccattgtctct
actgatccccaaaagctgccttttctgctcattctggatgccaaaagctttacggaattg
gcccgtgcctctgttgatgtcgatatgcacatggatctccatggattattcattacagac
atggactgggacacaaaaaagcaggccgcttctgaggaacagcgggacagggcttccgac
tgccacggggctcctctgacctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (3)   
   KEGG PATHWAY (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (15)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (13)   
DNA sequence (25)   
   RefSeq(nuc) (13)   
   GenBank (6)   
   EMBL (6)   
Protein domain (2)   
   Pfam (2)   
All databases (67)   

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