KEGG   Homo sapiens (human): 5431
Entry
5431              CDS       T01001                                 
Symbol
POLR2B, POL2RB, RPB2, hRPB140
Name
(RefSeq) RNA polymerase II subunit B
  KO
K03010  DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03020  RNA polymerase
hsa03420  Nucleotide excision repair
hsa05016  Huntington disease
Network
nt06502  Nucleotide excision repair
  Element
N01430  Transcription-coupled NER
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09121 Transcription
   03020 RNA polymerase
    5431 (POLR2B)
  09124 Replication and repair
   03420 Nucleotide excision repair
    5431 (POLR2B)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    5431 (POLR2B)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    5431 (POLR2B)
   03400 DNA repair and recombination proteins [BR:hsa03400]
    5431 (POLR2B)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.6  DNA-directed RNA polymerase
     5431 (POLR2B)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   RNA polymerase II
    Core subunits
     5431 (POLR2B)
DNA repair and recombination proteins [BR:hsa03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    TCR (transcription coupled repair) factors
     DNA-directed RNA polymerase II complex
      5431 (POLR2B)
SSDB
Motif
Pfam: RNA_pol_Rpb2_6 RNA_pol_Rpb2_1 RNA_pol_Rpb2_2 RNA_pol_Rpb2_7 RNA_pol_Rpb2_4 RNA_pol_Rpb2_3 RNA_pol_Rpb2_5
Other DBs
NCBI-GeneID: 5431
NCBI-ProteinID: NP_000929
OMIM: 180661
HGNC: 9188
Ensembl: ENSG00000047315
UniProt: P30876 B4DH29
Structure
Position
4:56978896..57031158
AA seq 1174 aa
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV
NT seq 3525 nt   +upstreamnt  +downstreamnt
atgtacgacgcggatgaggatatgcaatatgatgaggatgatgatgaaatcaccccggat
ttgtggcaagaagcatgctggattgtaatcagttcctattttgacgagaaaggcttggtt
agacaacagctggattcttttgatgagtttattcagatgtctgttcaaagaattgtggaa
gacgctcctcctatagacctacaggctgaagctcagcatgctagtggagaagttgaagaa
ccgccacgatatttgctgaagtttgaacaaatttatctttccaagcctacccattgggaa
agagatggtgctccttcaccaatgatgcccaatgaagctagattaaggaatctcacgtat
tctgctccgctttatgttgatataacaaaaacagtcattaaagaaggtgaagaacaactt
cagactcagcatcagaaaacttttataggaaaaattccaattatgttgcggtcaacttac
tgccttttgaatggcttgacagatcgtgatctttgtgagttaaatgaatgccctttggat
cctggtggctatttcattattaatggatcagaaaaggttctgattgcccaagagaaaatg
gcaacaaacacagtttatgtgtttgccaaaaaggattctaaatatgcctacacaggagag
tgtagatcatgtcttgagaattcttcccgacccaccagtactatatgggttagcatgctg
gcaagaggaggacagggtgccaagaagagtgctattggtcagcgcattgtggcaactcta
ccatatatcaagcaagaagttcccatcattattgtgttcagagcattaggttttgtgtcc
gacagagatattttagaacatattatttatgattttgaagatccagagatgatggaaatg
gttaaaccttctctcgatgaagcttttgtcatccaagaacagaatgttgcactaaatttc
attggttcaagaggagcaaagcctggtgttactaaagagaaaagaattaaatatgcaaag
gaagttttacaaaaagaaatgctccctcatgttggtgtcagtgatttttgtgagaccaaa
aaagcctatttcttgggatacatggttcataggttacttctggcagctttgggtagaaga
gaactagatgacagagatcactatggaaacaagagattggatcttgctgggccgctgctt
gcattcttatttagaggtatgtttaagaatttgcttaaagaagtgcggatctatgcacag
aaatttattgatcgaggaaaggattttaacttggagttggcaattaaaacacggatcata
tctgatggcctaaaatactctttagctactggaaactggggtgatcaaaagaaagctcat
caagccagagctggagtatctcaggtgttaaaccgcctgacttttgcgtctactctttct
cacctgcgtcgtttaaattctcctattggtagagacggcaagctagcaaaaccaagacag
ttgcataatacgttgtggggaatggtgtgtcctgccgagaccccagagggccatgctgta
ggacttgtgaagaatttagccttgatggcgtatatttcagttggatctcaaccatctcca
attctggaatttttagaagaatggagtatggaaaatttagaagaaatttctcctgcagct
attgctgatgcaaccaagatttttgttaatggctgctgggttggaatacataaagatccc
gaacaacttatgaacaccctaaggaaattgagacgtcagatggacatcattgtgtctgaa
gtttctatgatcagagatattcgagagagggagattcggatctatacggatgcaggccgt
atttgtagaccacttctgattgtggaaaaacaaaagctacttttgaagaagaggcatatt
gaccaattgaaagagagagaatataacaactatagttggcaggatcttgtggccagtggg
gtagtggagtatattgataccctggaagaagaaacagtgatgcttgcaatgactccagat
gatttacaggagaaagaagtagcttattgttccacatatacacactgtgagattcatccc
tcaatgatccttggtgtctgtgcatctattattccctttcctgatcataaccagtcccct
agaaacacataccagtctgctatgggtaagcaggctatgggagtttacatcaccaacttc
catgttcgcatggacacattggcccatgttctctattatcctcaaaagccacttgtgact
acacggtctatggaatatctacgatttagagagctgccagcaggcatcaactcaattgtg
gccattgcatcatacactggatataatcaggaagactctgttatcatgaatcgttcagct
gtagaccgcggcttcttcaggtctgttttctatcgctcatacaaagaacaggagtctaaa
aaaggatttgatcaagaagaagtttttgagaagcctacacgtgaaacatgccagggcatg
aggcatgccatttacgacaagctggatgatgatggtttgatagctccaggggttcgtgta
tcaggagatgatgttattataggcaaaacagtcaccttgcctgaaaatgaagatgaattg
gagagcaccaatagacgctataccaagagagactgtagcacttttctcagaactagcgag
acgggcattgtggatcaggttatggtaactctcaatcaggaaggatataaattttgtaaa
ataagggtacgctctgttaggattccacagattggagacaaatttgctagtcgacatggt
caaaagggtacttgtggtattcagtatagacaagaggatatgcctttcacctgtgaaggt
atcacccctgatatcatcatcaatccccatgccatcccctctcgtatgactattggtcac
ttaattgaatgccttcaagggaaggtatcggctaacaagggtgaaattggtgatgccact
ccatttaatgatgctgttaacgtgcagaagatttctaatcttttatctgattatggctat
catctcagaggaaatgaggtcctgtacaatgggttcactggtcgaaaaatcacatcacaa
atatttattggccccacttattaccagcgtttgaagcatatggtggatgataagattcac
tctcgtgctaggggacctattcagatcctcaatagacagcccatggagggtagatctcgt
gatggtggcctgcgttttggagaaatggaacgagattgtcagattgcccatggagcagcc
cagtttttaagggaaagattgtttgaggcatcagatccatatcaggttcatgtttgcaat
ctttgtggaataatggcgattgccaacaccaggacccatacatatgaatgcaggggctgc
cgcaataaaacccagatttctttggtgcgaatgccttacgcatgcaaactattgtttcag
gaacttatgtctatgagtattgcaccgcgaatgatgagtgtttag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (3)   
   KEGG PATHWAY (3)   
Network (2)   
   KEGG NETWORK (2)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (59)   
   KEGG ORTHOLOGY (1)   
   RefGene (49)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (3)   
   GenBank (11)   
   EMBL (11)   
3D Structure (12)   
   PDB (12)   
Protein domain (7)   
   Pfam (7)   
All databases (121)   

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