KEGG   Homo sapiens (human): 54363
Entry
54363             CDS       T01001                                 
Symbol
HAO1, GO, GOX, GOX1, HAOX1
Name
(RefSeq) hydroxyacid oxidase 1
  KO
K11517  (S)-2-hydroxy-acid oxidase [EC:1.1.3.15]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00630  Glyoxylate and dicarboxylate metabolism
hsa01100  Metabolic pathways
hsa01200  Carbon metabolism
hsa04146  Peroxisome
Drug target
Lumasiran: D11925 D11926<US>
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    54363 (HAO1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    54363 (HAO1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.15  (S)-2-hydroxy-acid oxidase
     54363 (HAO1)
SSDB
Motif
Pfam: FMN_dh IMPDH Glu_synthase His_biosynth ThiG TMP-TENI NMO DHO_dh Peptidase_C32
Other DBs
NCBI-GeneID: 54363
NCBI-ProteinID: NP_060015
OMIM: 605023
HGNC: 4809
Ensembl: ENSG00000101323
UniProt: Q9UJM8 A8K058
Structure
Position
20:complement(7882985..7940458)
AA seq 370 aa
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAET
DLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAE
AGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQ
LRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILR
GDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDV
LKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLV
RKNPLAVSKI
NT seq 1113 nt   +upstreamnt  +downstreamnt
atgctcccccggctaatttgtatcaatgattatgaacaacatgctaaatcagtacttcca
aagtctatatatgactattacaggtctggggcaaatgatgaagaaactttggctgataat
attgcagcattttccagatggaagctgtatccaaggatgctccggaatgttgctgaaaca
gatctgtcgacttctgttttaggacagagggtcagcatgccaatatgtgtgggggctacg
gccatgcagcgcatggctcatgtggacggcgagcttgccactgtgagagcctgtcagtcc
ctgggaacgggcatgatgttgagttcctgggccacctcctcaattgaagaagtggcggaa
gctggtcctgaggcacttcgttggctgcaactgtatatctacaaggaccgagaagtcacc
aagaagctagtgcggcaggcagagaagatgggctacaaggccatatttgtgacagtggac
acaccttacctgggcaaccgtctggatgatgtgcgtaacagattcaaactgccgccacaa
ctcaggatgaaaaattttgaaaccagtactttatcattttctcctgaggaaaattttgga
gacgacagtggacttgctgcatatgtggctaaagcaatagacccatctatcagctgggaa
gatatcaaatggctgagaagactgacatcattgccaattgttgcaaagggcattttgaga
ggtgatgatgccagggaggctgttaaacatggcttgaatgggatcttggtgtcgaatcat
ggggctcgacaactcgatggggtgccagccactattgatgttctgccagaaattgtggag
gctgtggaagggaaggtggaagtcttcctggacgggggtgtgcggaaaggcactgatgtt
ctgaaagctctggctcttggcgccaaggctgtgtttgtggggagaccaatcgtttggggc
ttagctttccagggggagaaaggtgttcaagatgtcctcgagatactaaaggaagaattc
cggttggccatggctctgagtgggtgccagaatgtgaaagtcatcgacaagacattggtg
aggaaaaatcctttggccgtttccaagatctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Disease (1)   
   OMIM (1)   
Drug (2)   
   KEGG DRUG (2)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (19)   
   RefSeq(nuc) (1)   
   GenBank (9)   
   EMBL (9)   
3D Structure (21)   
   PDB (21)   
Protein domain (9)   
   Pfam (9)   
All databases (78)   

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