KEGG   Homo sapiens (human): 5444
Entry
5444              CDS       T01001                                 
Symbol
PON1, ESA, MVCD5, PON
Name
(RefSeq) paraoxonase 1
  KO
K01045  arylesterase / paraoxonase [EC:3.1.1.2 3.1.8.1]
Organism
hsa  Homo sapiens (human)
Disease
H01457  Diabetic retinopathy
H02559  Microvascular complications of diabetes
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5444 (PON1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.2  arylesterase
     5444 (PON1)
   3.1.8  Phosphoric-triester hydrolases
    3.1.8.1  aryldialkylphosphatase
     5444 (PON1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   5444 (PON1)
  Exosomal proteins of other cancer cells
   5444 (PON1)
SSDB
Motif
Pfam: Arylesterase SGL Str_synth Lactonase
Other DBs
NCBI-GeneID: 5444
NCBI-ProteinID: NP_000437
OMIM: 168820
HGNC: 9204
Ensembl: ENSG00000005421
UniProt: P27169
Structure
Position
7:complement(95297676..95324532)
AA seq 355 aa
MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
NT seq 1068 nt   +upstreamnt  +downstreamnt
atggcgaagctgattgcgctcaccctcttggggatgggactggcactcttcaggaaccac
cagtcttcttaccaaacacgacttaatgctctccgagaggtacaacccgtagaacttcct
aactgtaatttagttaaaggaatcgaaactggctctgaagacttggagatactgcctaat
ggactggctttcattagctctggattaaagtatcctggaataaagagcttcaaccccaac
agtcctggaaaaatacttctgatggacctgaatgaagaagatccaacagtgttggaattg
gggatcactggaagtaaatttgatgtatcttcatttaaccctcatgggattagcacattc
acagatgaagataatgccatgtacctcctggtggtgaaccatccagatgccaagtccaca
gtggagttgtttaaatttcaagaagaagaaaaatcgcttttgcatctaaaaaccatcaga
cataaacttctgcctaatttgaatgatattgttgctgtgggacctgagcacttttatggc
acaaatgatcactattttcttgacccctacttacaatcctgggagatgtatttgggttta
gcgtggtcgtatgttgtctactatagtccaagtgaagttcgagtggtggcagaaggattt
gattttgctaatggaatcaacatttcacccgatggcaagtatgtctatatagctgagttg
ctggctcataagattcatgtgtatgaaaagcatgctaattggactttaactccattgaag
tcccttgactttaataccctcgtggataacatatctgtggatcctgagacaggagacctt
tgggttggatgccatcccaatggcatgaaaatcttcttctatgactcagagaatcctcct
gcatcagaggtgcttcgaatccagaacattctaacagaagaacctaaagtgacacaggtt
tatgcagaaaatggcacagtgttgcaaggcagtacagttgcctctgtgtacaaagggaaa
ctgctgattggcacagtgtttcacaaagctctttactgtgagctctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Disease (4)   
   KEGG DISEASE (2)   
   OMIM (2)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
   PROTHERM (2)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (25)   
   RefSeq(nuc) (1)   
   GenBank (12)   
   EMBL (12)   
3D Structure (1)   
   PDB (1)   
Protein domain (4)   
   Pfam (4)   
All databases (56)   

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