KEGG   Homo sapiens (human): 54658
Entry
54658             CDS       T01001                                 
Symbol
UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A
Name
(RefSeq) UDP glucuronosyltransferase family 1 member A1
  KO
K00699  glucuronosyltransferase [EC:2.4.1.17]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00040  Pentose and glucuronate interconversions
hsa00053  Ascorbate and aldarate metabolism
hsa00140  Steroid hormone biosynthesis
hsa00830  Retinol metabolism
hsa00860  Porphyrin metabolism
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa00982  Drug metabolism - cytochrome P450
hsa00983  Drug metabolism - other enzymes
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
hsa04976  Bile secretion
hsa05204  Chemical carcinogenesis - DNA adducts
hsa05207  Chemical carcinogenesis - receptor activation
Module
hsa_M00014  Glucuronate pathway (uronate pathway)
Disease
H00208  Hyperbilirubinemia
H02054  Crigler-Najjar syndrome
H02055  Gilbert syndrome
H02152  Transient familial neonatal hyperbilirubinemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00040 Pentose and glucuronate interconversions
    54658 (UGT1A1)
   00053 Ascorbate and aldarate metabolism
    54658 (UGT1A1)
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    54658 (UGT1A1)
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    54658 (UGT1A1)
   00860 Porphyrin metabolism
    54658 (UGT1A1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    54658 (UGT1A1)
   00982 Drug metabolism - cytochrome P450
    54658 (UGT1A1)
   00983 Drug metabolism - other enzymes
    54658 (UGT1A1)
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    54658 (UGT1A1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    54658 (UGT1A1)
   05207 Chemical carcinogenesis - receptor activation
    54658 (UGT1A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases [BR:hsa01003]
    54658 (UGT1A1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.17  glucuronosyltransferase
     54658 (UGT1A1)
Glycosyltransferases [BR:hsa01003]
 Others
  Hydrophobic molecule
   54658 (UGT1A1)
SSDB
Motif
Pfam: UDPGT EryCIII-like_C Glyco_tran_28_C
Other DBs
NCBI-GeneID: 54658
NCBI-ProteinID: NP_000454
OMIM: 191740
HGNC: 12530
Ensembl: ENSG00000241635
UniProt: P22309 Q5DT03
Position
2:233760270..233773300
AA seq 533 aa
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVL
APDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDS
AMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLE
FEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQR
EVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH
GIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDL
LGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS
EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHD
LTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
NT seq 1602 nt   +upstreamnt  +downstreamnt
atggctgtggagtcccagggcggacgcccacttgtcctgggcctgctgctgtgtgtgctg
ggcccagtggtgtcccatgctgggaagatactgttgatcccagtggatggcagccactgg
ctgagcatgcttggggccatccagcagctgcagcagaggggacatgaaatagttgtccta
gcacctgacgcctcgttgtacatcagagacggagcattttacaccttgaagacgtaccct
gtgccattccaaagggaggatgtgaaagagtcttttgttagtctcgggcataatgttttt
gagaatgattctttcctgcagcgtgtgatcaaaacatacaagaaaataaaaaaggactct
gctatgcttttgtctggctgttcccacttactgcacaacaaggagctcatggcctccctg
gcagaaagcagctttgatgtcatgctgacggaccctttccttccttgcagccccatcgtg
gcccagtacctgtctctgcccactgtattcttcttgcatgcactgccatgcagcctggaa
tttgaggctacccagtgccccaacccattctcctacgtgcccaggcctctctcctctcat
tcagatcacatgaccttcctgcagcgggtgaagaacatgctcattgccttttcacagaac
tttctgtgcgacgtggtttattccccgtatgcaacccttgcctcagaattccttcagaga
gaggtgactgtccaggacctattgagctctgcatctgtctggctgtttagaagtgacttt
gtgaaggattaccctaggcccatcatgcccaatatggtttttgttggtggaatcaactgc
cttcaccaaaatccactatcccaggaatttgaagcctacattaatgcttctggagaacat
ggaattgtggttttctctttgggatcaatggtctcagaaattccagagaagaaagctatg
gcaattgctgatgctttgggcaaaatccctcagacagtcctgtggcggtacactggaacc
cgaccatcgaatcttgcgaacaacacgatacttgttaagtggctaccccaaaacgatctg
cttggtcacccgatgacccgtgcctttatcacccatgctggttcccatggtgtttatgaa
agcatatgcaatggcgttcccatggtgatgatgcccttgtttggtgatcagatggacaat
gcaaagcgcatggagactaagggagctggagtgaccctgaatgttctggaaatgacttct
gaagatttagaaaatgctctaaaagcagtcatcaatgacaaaagttacaaggagaacatc
atgcgcctctccagccttcacaaggaccgcccggtggagccgctggacctggccgtgttc
tgggtggagtttgtgatgaggcacaagggcgcgccacacctgcgccccgcagcccacgac
ctcacctggtaccagtaccattccttggacgtgattggtttcctcttggccgtcgtgctg
acagtggccttcatcacctttaaatgttgtgcttatggctaccggaaatgcttggggaaa
aaagggcgagttaagaaagcccacaaatccaagacccattga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (15)   
   KEGG PATHWAY (13)   
   KEGG MODULE (2)   
Disease (10)   
   KEGG DISEASE (4)   
   OMIM (6)   
Chemical substance (40)   
   KEGG COMPOUND (40)   
Chemical reaction (21)   
   KEGG ENZYME (1)   
   KEGG REACTION (20)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (41)   
   RefSeq(nuc) (1)   
   GenBank (20)   
   EMBL (20)   
Protein domain (3)   
   Pfam (3)   
All databases (150)   

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