KEGG   Homo sapiens (human): 5469
Entry
5469              CDS       T01001                                 
Symbol
MED1, CRSP1, CRSP200, DRIP205, DRIP230, PBP, PPARBP, PPARGBP, RB18A, TRAP220, TRIP2
Name
(RefSeq) mediator complex subunit 1
  KO
K15144  mediator of RNA polymerase II transcription subunit 1
Organism
hsa  Homo sapiens (human)
Pathway
hsa01522  Endocrine resistance
hsa04919  Thyroid hormone signaling pathway
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    5469 (MED1)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    5469 (MED1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03021 Transcription machinery [BR:hsa03021]
    5469 (MED1)
Transcription machinery [BR:hsa03021]
 Eukaryotic type
  RNA polymerase II system
   Mediator complex
    Middle
     5469 (MED1)
SSDB
Motif
Pfam: Med1
Other DBs
NCBI-GeneID: 5469
NCBI-ProteinID: NP_004765
OMIM: 604311
HGNC: 9234
Ensembl: ENSG00000125686
UniProt: Q15648
Structure
Position
17:complement(39404285..39451263)
AA seq 1581 aa
MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
NPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTL
YGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQ
NPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVT
DILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAD
LIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFAS
QALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTT
GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGK
SPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSH
SQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGS
SQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPG
GSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTP
PSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPG
GEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSE
SKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGST
PKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKH
KKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRL
SPDFMIGEEDDDLMDVALIGN
NT seq 4746 nt   +upstreamnt  +downstreamnt
atgaaagctcagggggaaaccgaggagtcagaaaagctgagtaagatgagttctctcctg
gaacggctccatgcaaaatttaaccaaaatagaccctggagtgaaaccattaagcttgtg
cgtcaagtcatggagaagagggttgtgatgagttctggagggcatcaacatttggtcagc
tgtttggagacattgcagaaggctctcaaagtaacatctttaccagcaatgactgatcgt
ttggagtccatagcaagacagaatggactgggctctcatctcagtgccagtggcactgaa
tgttacatcacgtcagatatgttctatgtggaagtgcagttagatcctgcaggacagctt
tgtgatgtaaaagtggctcaccatggggagaatcctgtgagctgtccggagcttgtacag
cagctaagggaaaaaaattttgatgaattttctaagcaccttaagggccttgttaatctg
tataaccttccaggggacaacaaactgaagactaaaatgtacttggctctccaatcctta
gaacaagatctttctaaaatggcaattatgtactggaaagcaactaatgctggtcccttg
gataagattcttcatggaagtgttggctatctcacaccaaggagtgggggtcatttaatg
aacctgaagtactatgtctctccttctgacctactggatgacaagactgcatctcccatc
attttgcatgagaataatgtttctcgatctttgggcatgaatgcatcagtgacaattgaa
ggaacatctgctgtgtacaaactcccaattgcaccattaattatggggtcacatccagtt
gacaataaatggaccccttccttctcctcaatcaccagtgccaacagtgttgatcttcct
gcctgtttcttcttgaaatttccccagccaatcccagtatctagagcatttgttcagaaa
ctgcagaactgcacaggaattccattgtttgaaactcaaccaacttatgcacccctgtat
gaactgatcactcagtttgagctatcaaaggaccctgaccccatacctttgaatcacaac
atgagattttatgctgctcttcctggtcagcagcactgctatttcctcaacaaggatgct
cctcttccagatggccgaagtctacagggaacccttgttagcaaaatcacctttcagcac
cctggccgagttcctcttatcctaaatctgatcagacaccaagtggcctataacaccctc
attggaagctgtgtcaaaagaactattctgaaagaagattctcctgggcttctccaattt
gaagtgtgtcctctctcagagtctcgtttcagcgtatcttttcagcaccctgtgaatgac
tccctggtgtgtgtggtaatggatgtgcaggactcaacacatgtgagctgtaaactctac
aaagggctgtcggatgcactgatctgcacagatgacttcattgccaaagttgttcaaaga
tgtatgtccatccctgtgacgatgagggctattcggaggaaagctgaaaccattcaagcc
gacaccccagcactgtccctcattgcagagacagttgaagacatggtgaaaaagaacctg
cccccggctagcagcccagggtatggcatgaccacaggcaacaacccaatgagtggtacc
actacaccaaccaacacctttccggggggtcccattaccaccttgtttaatatgagcatg
agcatcaaagatcggcatgagtcggtgggccatggggaggacttcagcaaggtgtctcag
aacccaattcttaccagtttgttgcaaatcacagggaacggggggtctaccattggctcg
agtccgacccctcctcatcacacgccgccacctgtctcttcgatggccggcaacaccaag
aaccacccgatgctcatgaaccttcttaaagataatcctgcccaggatttctcaaccctt
tatggaagcagccctttagaaaggcagaactcctcttccggctcaccccgcatggaaata
tgctcggggagcaacaagaccaagaaaaagaagtcatcaagattaccacctgagaaacca
aagcaccagactgaagatgactttcagagggagctattttcaatggatgttgactcacag
aaccctatctttgatgtcaacatgacagctgacacgctggatacgccacacatcactcca
gctccaagccagtgtagcactcccccaacaacttacccacaaccagtacctcacccccaa
cccagtattcaaaggatggtccgactatccagttcagacagcattggcccagatgtaact
gacatcctttcagacattgcagaagaagcttctaaacttcccagcactagtgatgattgc
ccagccattggcacccctcttcgagattcttcaagctctgggcattctcagagtaccctg
tttgactctgatgtctttcaaactaacaataatgaaaatccatacactgatccagctgat
cttattgcagatgctgctggaagccccagtagtgactctcctaccaatcatttttttcat
gatggagtagatttcaatcctgatttattgaacagccagagccaaagtggttttggagaa
gaatattttgatgaaagcagccaaagtggggataatgatgatttcaaaggatttgcatct
caggcactaaatactttgggggtgccaatgcttggaggtgataatggggagaccaagttt
aagggcaataaccaagccgacacagttgatttcagtattatttcagtagccggcaaagct
ttagctcctgcagatcttatggagcatcacagtggtagtcagggtcctttactgaccact
ggggacttagggaaagaaaagactcaaaagagggtaaaggaaggcaatggcaccagtaat
agtactctctcggggcccggattagacagcaaaccagggaagcgcagtcggaccccttct
aatgatgggaaaagcaaagataagcctccaaagcggaagaaggcagacactgagggaaag
tctccatctcatagttcttctaacagaccttttaccccacctaccagtacaggtggatct
aaatcgccaggcagtgcaggaagatctcagactcccccaggtgttgccacaccacccatt
cccaaaatcactattcagattcctaagggaacagtgatggtgggcaagccttcctctcac
agtcagtataccagcagtggttctgtgtcttcctcaggcagcaaaagccaccatagccat
tcttcctcctcttcctcatctgcttccacctcagggaagatgaaaagcagtaaatcagaa
ggttcatcaagttccaagttaagtagcagtatgtattctagccaggggtcttctggatct
agccagtccaaaaattcatcccagtctggggggaagccaggctcctctcccataaccaag
catggactgagcagtggctctagcagcaccaagatgaaacctcaaggaaagccatcatca
cttatgaatccttctttaagtaaaccaaacatatccccttctcattcaaggccacctgga
ggctctgacaagcttgcctctccaatgaagcctgttcctggaactcctccatcctctaaa
gccaagtcccctatcagttcaggttctggtggttctcatatgtctggaactagttcaagc
tctggcatgaagtcatcttcagggttaggatcctcaggctcgttgtcccagaaaactccc
ccatcatctaattcctgtacggcatcttcctcctccttttcctcaagtggctcttccatg
tcatcctctcagaaccagcatgggagttctaaaggaaaatctcccagcagaaacaagaag
ccgtccttgacagctgtcatagataaactgaagcatggggttgtcaccagtggccctggg
ggtgaagacccactggacggccagatgggggtgagcacaaattcttccagccatcctatg
tcctccaaacataacatgtcaggaggagagtttcagggcaagcgtgagaaaagtgataaa
gacaaatcaaaggtttccacctccgggagttcagtggattcttctaagaagacctcagag
tcaaaaaatgtggggagcacaggtgtggcaaaaattatcatcagtaagcatgatggaggc
tcccctagcattaaagccaaagtgactttgcagaaacctggggaaagtagtggagaaggg
cttaggcctcaaatggcttcttctaaaaactatggctctccactcatcagtggttccact
ccaaagcatgagcgtggctctcccagccatagtaagtcaccagcatataccccccagaat
ctggacagtgaaagtgagtcaggctcctccatagcagagaaatcttatcagaatagtccc
agctcagacgatggtatccgaccacttccagaatacagcacagagaaacataagaagcac
aaaaaggaaaagaagaaagtaaaagacaaagatagggaccgagaccgggacaaagaccga
gacaagaaaaaatctcatagcatcaagccagagagttggtccaaatcacccatctcttca
gaccagtccttgtctatgacaagtaacacaatcttatctgcagacagaccctcaaggctc
agcccagactttatgattggggaggaagatgatgatcttatggatgtggccctgattggg
aattag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (27)   
   RefSeq(nuc) (7)   
   GenBank (10)   
   EMBL (10)   
3D Structure (60)   
   PDB (60)   
Protein domain (1)   
   Pfam (1)   
All databases (130)   

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