KEGG   Homo sapiens (human): 5478
Entry
5478              CDS       T01001                                 
Symbol
PPIA, CYPA, CYPH, HEL-S-69p
Name
(RefSeq) peptidylprolyl isomerase A
  KO
K03767  peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03250  Viral life cycle - HIV-1
hsa04217  Necroptosis
Drug target
Alisporivir: D10087
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03250 Viral life cycle - HIV-1
    5478 (PPIA)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    5478 (PPIA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:hsa03110]
    5478 (PPIA)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5478 (PPIA)
Enzymes [BR:hsa01000]
 5. Isomerases
  5.2  cis-trans-Isomerases
   5.2.1  cis-trans Isomerases (only sub-subclass identified to date)
    5.2.1.8  peptidylprolyl isomerase
     5478 (PPIA)
Chaperones and folding catalysts [BR:hsa03110]
 Protein folding catalysts
  Peptidyl prolyl isomerase
   Cyclophilin
    5478 (PPIA)
Exosome [BR:hsa04147]
 Exosomal proteins
  Proteins found in most exosomes
   5478 (PPIA)
SSDB
Motif
Pfam: Pro_isomerase
Other DBs
NCBI-GeneID: 5478
NCBI-ProteinID: NP_066953
OMIM: 123840
HGNC: 9253
Ensembl: ENSG00000196262
UniProt: P62937 V9HWF5
Structure
Position
7:44796681..44803117
AA seq 165 aa
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
NT seq 498 nt   +upstreamnt  +downstreamnt
atggtcaaccccaccgtgttcttcgacattgccgtcgacggcgagcccttgggccgcgtc
tcctttgagctgtttgcagacaaggtcccaaagacagcagaaaattttcgtgctctgagc
actggagagaaaggatttggttataagggttcctgctttcacagaattattccagggttt
atgtgtcagggtggtgacttcacacgccataatggcactggtggcaagtccatctatggg
gagaaatttgaagatgagaacttcatcctaaagcatacgggtcctggcatcttgtccatg
gcaaatgctggacccaacacaaatggttcccagtttttcatctgcactgccaagactgag
tggttggatggcaagcatgtggtgtttggcaaagtgaaagaaggcatgaatattgtggag
gccatggagcgctttgggtccaggaatggcaagaccagcaagaagatcaccattgctgac
tgtggacaactcgaataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (110)   
   KEGG ORTHOLOGY (1)   
   RefGene (18)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (86)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (71)   
   RefSeq(nuc) (7)   
   GenBank (32)   
   EMBL (32)   
3D Structure (159)   
   PDB (159)   
Protein domain (1)   
   Pfam (1)   
All databases (359)   

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