KEGG   Homo sapiens (human): 54790
Entry
54790             CDS       T01001                                 
Symbol
TET2, IMD75, KIAA1546, MDS
Name
(RefSeq) tet methylcytosine dioxygenase 2
  KO
K24309  methylcytosine dioxygenase TET2/3 [EC:1.14.11.80]
Organism
hsa  Homo sapiens (human)
Disease
H01481  Myelodysplastic syndrome
H01892  Peripheral T cell lymphoma
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:hsa03000]
    54790 (TET2)
   03036 Chromosome and associated proteins [BR:hsa03036]
    54790 (TET2)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.80  methylcytosine dioxygenase
     54790 (TET2)
Transcription factors [BR:hsa03000]
 Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    54790 (TET2)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Histone modification proteins
   Histone demethylases
    54790 (TET2)
SSDB
Motif
Pfam: Tet_JBP
Other DBs
NCBI-GeneID: 54790
NCBI-ProteinID: NP_001120680
OMIM: 612839
HGNC: 25941
Ensembl: ENSG00000168769
UniProt: Q6N021 A0A158SIU0
Structure
Position
4:105145875..105279803
AA seq 2002 aa
MEQDRTNHVEGNRLSPFLIPSPPICQTEPLATKLQNGSPLPERAHPEVNGDTKWHSFKSY
YGIPCMKGSQNSRVSPDFTQESRGYSKCLQNGGIKRTVSEPSLSGLLQIKKLKQDQKANG
ERRNFGVSQERNPGESSQPNVSDLSDKKESVSSVAQENAVKDFTSFSTHNCSGPENPELQ
ILNEQEGKSANYHDKNIVLLKNKAVLMPNGATVSASSVEHTHGELLEKTLSQYYPDCVSI
AVQKTTSHINAINSQATNELSCEITHPSHTSGQINSAQTSNSELPPKPAAVVSEACDADD
ADNASKLAAMLNTCSFQKPEQLQQQKSVFEICPSPAENNIQGTTKLASGEEFCSGSSSNL
QAPGGSSERYLKQNEMNGAYFKQSSVFTKDSFSATTTPPPPSQLLLSPPPPLPQVPQLPS
EGKSTLNGGVLEEHHHYPNQSNTTLLREVKIEGKPEAPPSQSPNPSTHVCSPSPMLSERP
QNNCVNRNDIQTAGTMTVPLCSEKTRPMSEHLKHNPPIFGSSGELQDNCQQLMRNKEQEI
LKGRDKEQTRDLVPPTQHYLKPGWIELKAPRFHQAESHLKRNEASLPSILQYQPNLSNQM
TSKQYTGNSNMPGGLPRQAYTQKTTQLEHKSQMYQVEMNQGQSQGTVDQHLQFQKPSHQV
HFSKTDHLPKAHVQSLCGTRFHFQQRADSQTEKLMSPVLKQHLNQQASETEPFSNSHLLQ
HKPHKQAAQTQPSQSSHLPQNQQQQQKLQIKNKEEILQTFPHPQSNNDQQREGSFFGQTK
VEECFHGENQYSKSSEFETHNVQMGLEEVQNINRRNSPYSQTMKSSACKIQVSCSNNTHL
VSENKEQTTHPELFAGNKTQNLHHMQYFPNNVIPKQDLLHRCFQEQEQKSQQASVLQGYK
NRNQDMSGQQAAQLAQQRYLIHNHANVFPVPDQGGSHTQTPPQKDTQKHAALRWHLLQKQ
EQQQTQQPQTESCHSQMHRPIKVEPGCKPHACMHTAPPENKTWKKVTKQENPPASCDNVQ
QKSIIETMEQHLKQFHAKSLFDHKALTLKSQKQVKVEMSGPVTVLTRQTTAAELDSHTPA
LEQQTTSSEKTPTKRTAASVLNNFIESPSKLLDTPIKNLLDTPVKTQYDFPSCRCVEQII
EKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVIYTGKEGKSSQGCPIAKWVV
RRSSSEEKLLCLVRERAGHTCEAAVIVILILVWEGIPLSLADKLYSELTETLRKYGTLTN
RRCALNEERTCACQGLDPETCGASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEE
KLESHLQNLSTLMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAH
AHRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGSVEAQEEKKR
SGAIQVLSSFRRKVRMLAEPVKTCRQRKLEAKKAAAEKLSSLENSSNKNEKEKSAPSRTK
QTENASQAKQLAELLRLSGPVMQQSQQPQPLQKQPPQPQQQQRPQQQQPHHPQTESVNSY
SASGSTNPYMRRPNPVSPYPNSSHTSDIYGSTSPMNFYSTSSQAAGSYLNSSNPMNPYPG
LLNQNTQYPSYQCNGNLSVDNCSPYLGSYSPQSQPMDLYRYPSQDPLSKLSLPPIHTLYQ
PRFGNSQSFTSKYLGYGNQNMQGDGFSSCTIRPNVHHVGKLPPYPTHEMDGHFMGATSRL
PPNLSNPNMDYKNGEHHSPSHIIHNYSAAPGMFNSSLHALHLQNKENDMLSHTANGLSKM
LPALNHDRTACVQGGLHKLSDANGQEKQPLALVQGVASGAEDNDEVWSDSEQSFLDPDIG
GVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMNEPKHGLALWEAK
MAEKAREKEEECEKYGPDYVPQKSHGKKVKREPAEPHETSEPTYLRFIKSLAERTMSVTT
DSTVTTSPYAFTRVTGPYNRYI
NT seq 6009 nt   +upstreamnt  +downstreamnt
atggaacaggatagaaccaaccatgttgagggcaacagactaagtccattcctgatacca
tcacctcccatttgccagacagaacctctggctacaaagctccagaatggaagcccactg
cctgagagagctcatccagaagtaaatggagacaccaagtggcactctttcaaaagttat
tatggaataccctgtatgaagggaagccagaatagtcgtgtgagtcctgactttacacaa
gaaagtagagggtattccaagtgtttgcaaaatggaggaataaaacgcacagttagtgaa
ccttctctctctgggctccttcagatcaagaaattgaaacaagaccaaaaggctaatgga
gaaagacgtaacttcggggtaagccaagaaagaaatccaggtgaaagcagtcaaccaaat
gtctccgatttgagtgataagaaagaatctgtgagttctgtagcccaagaaaatgcagtt
aaagatttcaccagtttttcaacacataactgcagtgggcctgaaaatccagagcttcag
attctgaatgagcaggaggggaaaagtgctaattaccatgacaagaacattgtattactt
aaaaacaaggcagtgctaatgcctaatggtgctacagtttctgcctcttccgtggaacac
acacatggtgaactcctggaaaaaacactgtctcaatattatccagattgtgtttccatt
gcggtgcagaaaaccacatctcacataaatgccattaacagtcaggctactaatgagttg
tcctgtgagatcactcacccatcgcatacctcagggcagatcaattccgcacagacctct
aactctgagctgcctccaaagccagctgcagtggtgagtgaggcctgtgatgctgatgat
gctgataatgccagtaaactagctgcaatgctaaatacctgttcctttcagaaaccagaa
caactacaacaacaaaaatcagtttttgagatatgcccatctcctgcagaaaataacatc
cagggaaccacaaagctagcgtctggtgaagaattctgttcaggttccagcagcaatttg
caagctcctggtggcagctctgaacggtatttaaaacaaaatgaaatgaatggtgcttac
ttcaagcaaagctcagtgttcactaaggattccttttctgccactaccacaccaccacca
ccatcacaattgcttctttctccccctcctcctcttccacaggttcctcagcttccttca
gaaggaaaaagcactctgaatggtggagttttagaagaacaccaccactaccccaaccaa
agtaacacaacacttttaagggaagtgaaaatagagggtaaacctgaggcaccaccttcc
cagagtcctaatccatctacacatgtatgcagcccttctccgatgctttctgaaaggcct
cagaataattgtgtgaacaggaatgacatacagactgcagggacaatgactgttccattg
tgttctgagaaaacaagaccaatgtcagaacacctcaagcataacccaccaatttttggt
agcagtggagagctacaggacaactgccagcagttgatgagaaacaaagagcaagagatt
ctgaagggtcgagacaaggagcaaacacgagatcttgtgcccccaacacagcactatctg
aaaccaggatggattgaattgaaggcccctcgttttcaccaagcggaatcccatctaaaa
cgtaatgaggcatcactgccatcaattcttcagtatcaacccaatctctccaatcaaatg
acctccaaacaatacactggaaattccaacatgcctggggggctcccaaggcaagcttac
acccagaaaacaacacagctggagcacaagtcacaaatgtaccaagttgaaatgaatcaa
gggcagtcccaaggtacagtggaccaacatctccagttccaaaaaccctcacaccaggtg
cacttctccaaaacagaccatttaccaaaagctcatgtgcagtcactgtgtggcactaga
tttcattttcaacaaagagcagattcccaaactgaaaaacttatgtccccagtgttgaaa
cagcacttgaatcaacaggcttcagagactgagccattttcaaactcacaccttttgcaa
cataagcctcataaacaggcagcacaaacacaaccatcccagagttcacatctccctcaa
aaccagcaacagcagcaaaaattacaaataaagaataaagaggaaatactccagactttt
cctcacccccaaagcaacaatgatcagcaaagagaaggatcattctttggccagactaaa
gtggaagaatgttttcatggtgaaaatcagtattcaaaatcaagcgagttcgagactcat
aatgtccaaatgggactggaggaagtacagaatataaatcgtagaaattccccttatagt
cagaccatgaaatcaagtgcatgcaaaatacaggtttcttgttcaaacaatacacaccta
gtttcagagaataaagaacagactacacatcctgaactttttgcaggaaacaagacccaa
aacttgcatcacatgcaatattttccaaataatgtgatcccaaagcaagatcttcttcac
aggtgctttcaagaacaggagcagaagtcacaacaagcttcagttctacagggatataaa
aatagaaaccaagatatgtctggtcaacaagctgcgcaacttgctcagcaaaggtacttg
atacataaccatgcaaatgtttttcctgtgcctgaccagggaggaagtcacactcagacc
cctccccagaaggacactcaaaagcatgctgctctaaggtggcatctcttacagaagcaa
gaacagcagcaaacacagcaaccccaaactgagtcttgccatagtcagatgcacaggcca
attaaggtggaacctggatgcaagccacatgcctgtatgcacacagcaccaccagaaaac
aaaacatggaaaaaggtaactaagcaagagaatccacctgcaagctgtgataatgtgcag
caaaagagcatcattgagaccatggagcagcatctgaagcagtttcacgccaagtcgtta
tttgaccataaggctcttactctcaaatcacagaagcaagtaaaagttgaaatgtcaggg
ccagtcacagttttgactagacaaaccactgctgcagaacttgatagccacaccccagct
ttagagcagcaaacaacttcttcagaaaagacaccaaccaaaagaacagctgcttctgtt
ctcaataattttatagagtcaccttccaaattactagatactcctataaaaaatttattg
gatacacctgtcaagactcaatatgatttcccatcttgcagatgtgtagagcaaattatt
gaaaaagatgaaggtcctttttatacccatctaggagcaggtcctaatgtggcagctatt
agagaaatcatggaagaaaggtttggacagaagggtaaagctattaggattgaaagagtc
atctatactggtaaagaaggcaaaagttctcagggatgtcctattgctaagtgggtggtt
cgcagaagcagcagtgaagagaagctactgtgtttggtgcgggagcgagctggccacacc
tgtgaggctgcagtgattgtgattctcatcctggtgtgggaaggaatcccgctgtctctg
gctgacaaactctactcggagcttaccgagacgctgaggaaatacggcacgctcaccaat
cgccggtgtgccttgaatgaagagagaacttgcgcctgtcaggggctggatccagaaacc
tgtggtgcctccttctcttttggttgttcatggagcatgtactacaatggatgtaagttt
gccagaagcaagatcccaaggaagtttaagctgcttggggatgacccaaaagaggaagag
aaactggagtctcatttgcaaaacctgtccactcttatggcaccaacatataagaaactt
gcacctgatgcatataataatcagattgaatatgaacacagagcaccagagtgccgtctg
ggtctgaaggaaggccgtccattctcaggggtcactgcatgtttggacttctgtgctcat
gcccacagagacttgcacaacatgcagaatggcagcacattggtatgcactctcactaga
gaagacaatcgagaatttggaggaaaacctgaggatgagcagcttcacgttctgccttta
tacaaagtctctgacgtggatgagtttgggagtgtggaagctcaggaggagaaaaaacgg
agtggtgccattcaggtactgagttcttttcggcgaaaagtcaggatgttagcagagcca
gtcaagacttgccgacaaaggaaactagaagccaagaaagctgcagctgaaaagctttcc
tccctggagaacagctcaaataaaaatgaaaaggaaaagtcagccccatcacgtacaaaa
caaactgaaaacgcaagccaggctaaacagttggcagaacttttgcgactttcaggacca
gtcatgcagcagtcccagcagccccagcctctacagaagcagccaccacagccccagcag
cagcagagaccccagcagcagcagccacatcaccctcagacagagtctgtcaactcttat
tctgcttctggatccaccaatccatacatgagacggcccaatccagttagtccttatcca
aactcttcacacacttcagatatctatggaagcaccagccctatgaacttctattccacc
tcatctcaagctgcaggttcatatttgaattcttctaatcccatgaacccttaccctggg
cttttgaatcagaatacccaatatccatcatatcaatgcaatggaaacctatcagtggac
aactgctccccatatctgggttcctattctccccagtctcagccgatggatctgtatagg
tatccaagccaagaccctctgtctaagctcagtctaccacccatccatacactttaccag
ccaaggtttggaaatagccagagttttacatctaaatacttaggttatggaaaccaaaat
atgcagggagatggtttcagcagttgtaccattagaccaaatgtacatcatgtagggaaa
ttgcctccttatcccactcatgagatggatggccacttcatgggagccacctctagatta
ccacccaatctgagcaatccaaacatggactataaaaatggtgaacatcattcaccttct
cacataatccataactacagtgcagctccgggcatgttcaacagctctcttcatgccctg
catctccaaaacaaggagaatgacatgctttcccacacagctaatgggttatcaaagatg
cttccagctcttaaccatgatagaactgcttgtgtccaaggaggcttacacaaattaagt
gatgctaatggtcaggaaaagcagccattggcactagtccagggtgtggcttctggtgca
gaggacaacgatgaggtctggtcagacagcgagcagagctttctggatcctgacattggg
ggagtggccgtggctccaactcatgggtcaattctcattgagtgtgcaaagcgtgagctg
catgccacaacccctttaaagaatcccaataggaatcaccccaccaggatctccctcgtc
ttttaccagcataagagcatgaatgagccaaaacatggcttggctctttgggaagccaaa
atggctgaaaaagcccgtgagaaagaggaagagtgtgaaaagtatggcccagactatgtg
cctcagaaatcccatggcaaaaaagtgaaacgggagcctgctgagccacatgaaacttca
gagcccacttacctgcgtttcatcaagtctcttgccgaaaggaccatgtccgtgaccaca
gactccacagtaactacatctccatatgccttcactcgggtcacagggccttacaacaga
tatatatga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Disease (8)   
   KEGG DISEASE (5)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (47)   
   KEGG ORTHOLOGY (1)   
   RefGene (41)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (25)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (22)   
DNA sequence (58)   
   RefSeq(nuc) (24)   
   GenBank (17)   
   EMBL (17)   
3D Structure (5)   
   PDB (5)   
Protein domain (1)   
   Pfam (1)   
All databases (150)   

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