| Entry |
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| Symbol |
PPP1CB, HEL-S-80p, MP, NSLH2, PP-1B, PP1B, PP1beta, PP1c, PPP1CD, PPP1beta
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| Name |
(RefSeq) protein phosphatase 1 catalytic subunit beta
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| KO |
| K06269 | serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16] |
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| Organism |
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| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa05168 | Herpes simplex virus 1 infection |
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| Network |
nt06168 Herpes simplex virus 1 (HSV-1) nt06515 Regulation of kinetochore-microtubule interactions nt06526 MAPK signaling |
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| Element |
| N00572 | HSV ICP34.5 to PKR-eIF2alpha signaling pathway |
| N01531 | CENPE interaction with NDC80 complex |
| N01536 | Dephosphorylation of kinetochore |
| N01598 | Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase |
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| Disease |
| H00523 | Noonan syndrome and related disorders |
| H02191 | Noonan-like syndrome with loose anagen hair |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09120 Genetic Information Processing
09122 Translation
03015 mRNA surveillance pathway
5500 (PPP1CB)
09130 Environmental Information Processing
09132 Signal transduction
04390 Hippo signaling pathway
5500 (PPP1CB)
04024 cAMP signaling pathway
5500 (PPP1CB)
04022 cGMP-PKG signaling pathway
5500 (PPP1CB)
09140 Cellular Processes
09143 Cell growth and death
04114 Oocyte meiosis
5500 (PPP1CB)
04218 Cellular senescence
5500 (PPP1CB)
09144 Cellular community - eukaryotes
04510 Focal adhesion
5500 (PPP1CB)
09142 Cell motility
04810 Regulation of actin cytoskeleton
5500 (PPP1CB)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
5500 (PPP1CB)
09152 Endocrine system
04910 Insulin signaling pathway
5500 (PPP1CB)
04921 Oxytocin signaling pathway
5500 (PPP1CB)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
5500 (PPP1CB)
04270 Vascular smooth muscle contraction
5500 (PPP1CB)
09156 Nervous system
04728 Dopaminergic synapse
5500 (PPP1CB)
04720 Long-term potentiation
5500 (PPP1CB)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
5500 (PPP1CB)
09160 Human Diseases
09161 Cancer: overview
05205 Proteoglycans in cancer
5500 (PPP1CB)
09172 Infectious disease: viral
05168 Herpes simplex virus 1 infection
5500 (PPP1CB)
09165 Substance dependence
05031 Amphetamine addiction
5500 (PPP1CB)
05034 Alcoholism
5500 (PPP1CB)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
5500 (PPP1CB)
09167 Endocrine and metabolic disease
04931 Insulin resistance
5500 (PPP1CB)
09180 Brite Hierarchies
09181 Protein families: metabolism
01009 Protein phosphatases and associated proteins [BR:hsa01009]
5500 (PPP1CB)
09182 Protein families: genetic information processing
03021 Transcription machinery [BR:hsa03021]
5500 (PPP1CB)
03019 Messenger RNA biogenesis [BR:hsa03019]
5500 (PPP1CB)
03041 Spliceosome [BR:hsa03041]
5500 (PPP1CB)
Enzymes [BR:hsa01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.3 Phosphoric-monoester hydrolases
3.1.3.16 protein-serine/threonine phosphatase
5500 (PPP1CB)
Protein phosphatases and associated proteins [BR:hsa01009]
Protein serine/threonine phosphatases
Phosphoprotein phosphatases (PPPs)
Protein phosphatase-1
Catalytic subunits
5500 (PPP1CB)
Transcription machinery [BR:hsa03021]
Eukaryotic type
RNA polymerase II system
Other transcription-related factors
Transcription termination factor
5500 (PPP1CB)
Messenger RNA biogenesis [BR:hsa03019]
Eukaryotic type
mRNA processing factors
3' end processing
Cleavage and polyadenylation specificity factor (CPSF) complex
5500 (PPP1CB)
Spliceosome [BR:hsa03041]
Other splicing related proteins
Spliceosome associated proteins (SAPs)
Other SAPs
5500 (PPP1CB)
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| SSDB |
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| Motif |
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| Other DBs |
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| Position |
2:28751604..28802940
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| AA seq |
327 aa
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKI
CGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
RGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQ
SMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDL
DLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
KAKYQYGGLNSGRPVTPPRTANPPKKR |
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| NT seq |
984 nt +upstreamnt +downstreamnt
atggcggacggggagctgaacgtggacagcctcatcacccggctgctggaggtacgagga
tgtcgtccaggaaagattgtgcagatgactgaagcagaagttcgaggcttatgtatcaag
tctcgggagatctttctcagccagcctattcttttggaattggaagcaccgctgaaaatt
tgtggagatattcatggacaatatacagatttactgagattatttgaatatggaggtttc
ccaccagaagccaactatcttttcttaggagattatgtggacagaggaaagcagtctttg
gaaaccatttgtttgctattggcttataaaatcaaatatccagagaacttctttctctta
agaggaaaccatgagtgtgctagcatcaatcgcatttatggattctatgatgaatgcaaa
cgaagatttaatattaaattgtggaagaccttcactgattgttttaactgtctgcctata
gcagccattgtggatgagaagatcttctgttgtcatggaggattgtcaccagacctgcaa
tctatggagcagattcggagaattatgagacctactgatgtccctgatacaggtttgctc
tgtgatttgctatggtctgatccagataaggatgtgcaaggctggggagaaaatgatcgt
ggtgtttcctttacttttggagctgatgtagtcagtaaatttctgaatcgtcatgattta
gatttgatttgtcgagctcatcaggtggtggaagatggatatgaattttttgctaaacga
cagttggtaaccttattttcagccccaaattactgtggcgagtttgataatgctggtgga
atgatgagtgtggatgaaactttgatgtgttcatttcagatattgaaaccatctgaaaag
aaagctaaataccagtatggtggactgaattctggacgtcctgtcactccacctcgaaca
gctaatccgccgaagaaaaggtga |
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