KEGG   Homo sapiens (human): 55191
Entry
55191             CDS       T01001                                 
Symbol
NADSYN1, VCRL3
Name
(RefSeq) NAD synthetase 1
  KO
K01950  NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00760  Nicotinate and nicotinamide metabolism
hsa01100  Metabolic pathways
hsa01240  Biosynthesis of cofactors
Module
hsa_M00912  NAD biosynthesis, tryptophan => quinolinate => NAD
Network
nt06036  Lysine degradation
  Element
N01723  NAD biosynthesis
Disease
H02087  Vertebral, cardiac, renal, and limb defects syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    55191 (NADSYN1)
Enzymes [BR:hsa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.1  NAD+ synthase (glutamine-hydrolysing)
     55191 (NADSYN1)
SSDB
Motif
Pfam: CN_hydrolase NAD_synthase
Other DBs
NCBI-GeneID: 55191
NCBI-ProteinID: NP_060631
OMIM: 608285
HGNC: 29832
Ensembl: ENSG00000172890
UniProt: Q6IA69
Structure
Position
11:71453203..71501816
AA seq 706 aa
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYES
DTLLHSFQVLAALVESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRL
YYDGCAMIAMNGSVFAQGSQFSLDDVEVLTATLDLEDVRSYRAEISSRNLAASRASPYPR
VKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGNEEVLADVRTIVNQISYTPQDPRDLCGRILTTCYMAS
KNSSQETCTRARELAQQIGSHHISLNIDPAVKAVMGIFSLVTGKSPLFAAHGGSSRENLA
LQNVQARIRMVLAYLFAQLSLWSRGVHGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQFCIQRFQLPALQSILLAPATAELEPLADGQVSQTDEEDMGMTYAELSV
YGKLRKVAKMGPYSMFCKLLGMWRHICTPRQVADKVKRFFSKYSMNRHKMTTLTPAYHAE
NYSPEDNRFDLRPFLYNTSWPWQFRCIENQVLQLERAEPQSLDGVD
NT seq 2121 nt   +upstreamnt  +downstreamnt
atgggccggaaggtgaccgtggccacctgcgcactcaaccagtgggccctggacttcgag
ggcaatttgcaaagaattttaaagagtattgaaattgccaaaaacagaggagcaagatac
aggcttggaccagagctggaaatatgcggctacggatgttgggatcattattacgagtcg
gacaccctcttgcactcgtttcaagtcctagcggcccttgtggagtctcccgtcactcag
gacatcatctgcgacgtggggatgcctgtaatgcaccgaaacgtccgctacaactgcaga
gtgatattcctcaacaggaagatcctgctcatcagacccaagatggccttggccaatgaa
ggcaactaccgcgagctgcgctggttcaccccgtggtcgaggagtcggcacacagaggag
tactttctgcctcggatgatacaggacctgacaaagcaggaaaccgtacccttcggagat
gcggtgctggtgacatgggacacctgcattggaagtgagatctgtgaggagctctggaca
ccccacagcccgcacatcgacatgggcctggatggcgtggagatcatcaccaacgcctcg
ggcagccaccaagtgctgcgcaaagccaacaccagggtggatctcgtgactatggtcacc
agcaagaacggtgggatttacttgctggccaaccagaagggttgtgacggggaccgcctg
tactacgacggctgtgccatgattgccatgaacggaagcgtctttgctcaaggatcccag
ttttctctggatgacgtggaagtcctgacggccacgctggatctggaggacgtccggagc
tacagggcggagatttcatctcgaaacctggcggccagcagggcgagcccctaccccaga
gtgaaggtggactttgccctctcgtgccacgaggacttgctggcacccatctctgagccc
atcgagtggaaataccacagccctgaggaggagataagccttggacctgcctgctggctc
tgggattttttaagacgaagtcaacaggcagggtttttgctgcccttgagtggcggggtg
gacagcgcagccaccgcctgcctcatctactccatgtgctgccaggtctgcgaggccgtg
aggagtggaaatgaggaagtgctggctgatgtccgcaccatcgtgaaccagatcagctac
accccccaggatccccgagacctctgtggacgcatactgaccacctgctacatggccagc
aagaactcctcccaggagacgtgcacccgggccagagagttggcccagcagattggaagc
caccacatcagtctcaacatcgatccagccgtgaaggccgtcatgggcatcttcagcctg
gtgacggggaagagccctctgtttgcagctcatggaggaagcagcagggaaaacctggcg
ctgcaaaatgtgcaggctcgaatacggatggtcctcgcctatctgtttgctcagttgagc
ctctggtctcggggtgtccacggtgggctcctcgtgctgggatccgccaacgtggatgag
agtctcctgggctacctgaccaagtacgactgctccagtgcggacatcaaccccataggc
gggatcagcaagacggacctcagggccttcgtccagttctgcatccagcgcttccagctt
cctgccctgcagagcatcctgttggcgccggccaccgcagagctggagcccttggctgat
ggacaggtgtcccagaccgacgaggaagatatggggatgacatatgcggagctctcggtc
tatgggaaactcaggaaggtggccaagatggggccctacagcatgttctgcaaactcctc
ggcatgtggagacacatctgcaccccgagacaggtcgctgacaaagtgaagcggtttttc
tccaagtactccatgaacagacacaagatgaccacgctcacacccgcgtaccacgccgag
aactacagccctgaggacaacaggtttgatctgcgaccatttctgtacaacacaagctgg
ccttggcagtttcggtgcatagaaaatcaggtgctacagctcgagagggcagagccacag
tccctggacggcgtggactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Network (2)   
   KEGG NETWORK (2)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (14)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (35)   
   RefSeq(nuc) (1)   
   GenBank (17)   
   EMBL (17)   
3D Structure (1)   
   PDB (1)   
Protein domain (2)   
   Pfam (2)   
All databases (78)   

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