KEGG   Homo sapiens (human): 55621
Entry
55621             CDS       T01001                                 
Symbol
TRMT1, MRT68, TRM1
Name
(RefSeq) tRNA methyltransferase 1
  KO
K00555  tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
Organism
hsa  Homo sapiens (human)
Disease
H00768  Autosomal recessive intellectual developmental disorder
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    55621 (TRMT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.215  tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase
     55621 (TRMT1)
    2.1.1.216  tRNA (guanine26-N2)-dimethyltransferase
     55621 (TRMT1)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  tRNA modification factors
   Methyltransferases
    55621 (TRMT1)
SSDB
Motif
Pfam: TRM zf-CCCH Met_10 Torus Cons_hypoth95 zf_CCCH_4 Defensin_int zf-CCCH_4
Other DBs
NCBI-GeneID: 55621
NCBI-ProteinID: NP_001129507
OMIM: 611669
HGNC: 25980
Ensembl: ENSG00000104907
UniProt: Q9NXH9
Structure
Position
19:complement(13104907..13116740)
AA seq 659 aa
MQGSSLWLSLTFRSARVLSRARFFEWQSPGLPNTAAMENGTGPYGEERPREVQETTVTEG
AAKIAFPSANEVFYNPVQEFNRDLTCAVITEFARIQLGAKGIQIKVPGEKDTQKVVVDLS
EQEEEKVELKESENLASGDQPRTAAVGEICEEGLHVLEGLAASGLRSIRFALEVPGLRSV
VANDASTRAVDLIRRNVQLNDVAHLVQPSQADARMLMYQHQRVSERFDVIDLDPYGSPAT
FLDAAVQAVSEGGLLCVTCTDMAVLAGNSGETCYSKYGAMALKSRACHEMALRIVLHSLD
LRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLG
KASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPG
RFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSH
ACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDAN
PSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAAR
LKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAAGPGID
NT seq 1980 nt   +upstreamnt  +downstreamnt
atgcaaggatcgtctctgtggctaagcctcactttccgctccgcccgggtgctctctaga
gcccggtttttcgagtggcagtctccagggctgccgaatacagcagcgatggagaacggc
accgggccctacggagaagaacgtccacgtgaagtccaggagacgacagtcaccgagggg
gctgccaaaatcgcctttcccagtgccaacgaggtcttttataacccggtgcaggaattc
aatcgggacctgacatgtgctgtgatcaccgagtttgctcgcattcagcttggggccaaa
ggaatccagatcaaggttccaggagagaaggacacgcaaaaagtggtcgtggacttgtca
gagcaagaggaggaaaaggttgaactgaaagagagtgaaaacctggcctcaggagaccaa
cctcgcacagcggccgtgggggagatctgtgaggaaggcctgcatgtgctggaaggcctg
gcagcttcaggcctacgttccattcgatttgccctagaggtgcctgggctcagatctgtg
gttgcaaacgatgcctccacccgggctgtggatctcatacgccggaatgtccagctcaat
gacgtggcccacctggtacagccgagccaagcagatgcccggatgctgatgtaccagcac
cagagggtgtcggagaggtttgacgtcatcgatctggacccctatggcagcccagccacc
ttcctggatgcagctgtgcaggctgtgagtgaaggagggttgctgtgtgtgacctgcaca
gacatggcggtgttggcggggaacagcggggagacgtgctacagcaagtacggggccatg
gccctcaagagccgggcctgccacgagatggccctgagaatcgtcctgcacagcctggac
ctccgcgccaactgctaccagcgcttcgtggtgccgctgctcagcatcagcgctgacttc
tacgtgcgtgtttttgtccgtgtcttcaccggccaggccaaggtcaaggcctcagccagc
aagcaggcgctggtgttccagtgtgtgggctgcggggccttccaccttcagcgtctcggc
aaagcgtcaggagtccccagcggccgggccaagttctctgcagcctgtggtccccctgtg
acccccgagtgtgaacactgtgggcaacgacaccagcttggtggccccatgtgggcagag
cccatccatgacctggattttgtgggccgtgtcctggaggctgtgagcgctaaccccggc
cgcttccacacctcggagcggatccgaggggtcctgagcgtcatcactgaggagctcccg
gacgtgcctctgtactacaccctggaccagctgagcagcaccatccactgcaacacacca
agcctcctgcagttgcggtcggccctcctccacgctgacttccgggtctcactctcccac
gcctgtaagaacgctgtgaagacggatgcccctgcctctgccctctgggacatcatgcgt
tgctgggagaaggaatgtccggtgaaacgggagcgactatcagagactagcccagcgttc
cgcattctcagtgtggagcccaggctgcaggccaacttcaccatccgggaagatgccaac
cccagctcccgacagcgaggactcaagcgcttccaggctaacccggaggccaactggggt
ccccggcctcgtgcccggccagggggcaaggcggccgacgaagctatggaggagagacgc
aggctgcttcagaacaagcggaaggagccgccggaagatgtggcccagcgggctgcccgg
ctcaagacatttccttgcaagaggtttaaggagggcacctgtcaacgcggggaccagtgc
tgctactcccacagccccccgacacccagggtttctgctgatgctgcccctgactgtcca
gagacctccaaccagaccccccctggacctggggctgccgctgggccaggcatagactga

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Ontology (3)   
   KEGG BRITE (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (42)   
   RefSeq(nuc) (6)   
   GenBank (18)   
   EMBL (18)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (85)   

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