KEGG T01001: 5608

Homo sapiens (human): 5608

Entry

5608              CDS       T01001

Symbol

MAP2K6, MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3

Name

(RefSeq) mitogen-activated protein kinase kinase 6

K04433

mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa04010

MAPK signaling pathway

hsa04015

Rap1 signaling pathway

hsa04218

Cellular senescence

hsa04380

Osteoclast differentiation

hsa04620

Toll-like receptor signaling pathway

hsa04664

Fc epsilon RI signaling pathway

hsa04668

TNF signaling pathway

hsa04750

Inflammatory mediator regulation of TRP channels

hsa04912

GnRH signaling pathway

hsa04935

Growth hormone synthesis, secretion and action

hsa04936

Alcoholic liver disease

hsa05014

Amyotrophic lateral sclerosis

hsa05022

Pathways of neurodegeneration - multiple diseases

hsa05132

Salmonella infection

hsa05135

Yersinia infection

hsa05145

Toxoplasmosis

hsa05161

Hepatitis B

hsa05163

Human cytomegalovirus infection

hsa05167

Kaposi sarcoma-associated herpesvirus infection

hsa05169

Epstein-Barr virus infection

hsa05170

Human immunodeficiency virus 1 infection

hsa05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

hsa05417

Lipid and atherosclerosis

hsa05418

Fluid shear stress and atherosclerosis

Network

nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06180  Pathogenic Escherichia coli
nt06182  Shigella
nt06183  Yersinia
nt06211  Other MAPK signaling (cancer)
nt06263  Hepatocellular carcinoma
nt06516  TNF signaling
nt06517  TLR signaling
nt06526  MAPK signaling

Element

N00186

IL1-IL1R-p38 signaling pathway

N00438

TLR2/4-MAPK signaling pathway

N00444

TNF-p38 signaling pathway

N00862

Yersinia YopP/J to TLR2/4-MAPK signaling pathway

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    5608 (MAP2K6)
   04015 Rap1 signaling pathway
    5608 (MAP2K6)
   04668 TNF signaling pathway
    5608 (MAP2K6)
09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    5608 (MAP2K6)
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    5608 (MAP2K6)
   04664 Fc epsilon RI signaling pathway
    5608 (MAP2K6)
  09152 Endocrine system
   04912 GnRH signaling pathway
    5608 (MAP2K6)
   04935 Growth hormone synthesis, secretion and action
    5608 (MAP2K6)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    5608 (MAP2K6)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    5608 (MAP2K6)
09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    5608 (MAP2K6)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    5608 (MAP2K6)
   05161 Hepatitis B
    5608 (MAP2K6)
   05163 Human cytomegalovirus infection
    5608 (MAP2K6)
   05167 Kaposi sarcoma-associated herpesvirus infection
    5608 (MAP2K6)
   05169 Epstein-Barr virus infection
    5608 (MAP2K6)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    5608 (MAP2K6)
   05135 Yersinia infection
    5608 (MAP2K6)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    5608 (MAP2K6)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    5608 (MAP2K6)
   05022 Pathways of neurodegeneration - multiple diseases
    5608 (MAP2K6)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    5608 (MAP2K6)
   05418 Fluid shear stress and atherosclerosis
    5608 (MAP2K6)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    5608 (MAP2K6)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    5608 (MAP2K6)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     5608 (MAP2K6)
Protein kinases [BR:hsa01001]
Serine/threonine kinases: STE group
  STE7 family
   5608 (MAP2K6)

SSDB

Motif

Pfam:

Pkinase PK_Tyr_Ser-Thr Kinase-like ABC1 Seadorna_VP7 Pkinase_fungal Haspin_kinase DUF4344 Choline_kinase APH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

Position

17:69414697..69553865

AA seq 334 aa
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELG
RGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKGTDVASFVKLILGD

NT seq 1005 nt +upstreamnt +downstreamnt
atgtctcagtcgaaaggcaagaagcgaaaccctggccttaaaattccaaaagaagcattt
gaacaacctcagaccagttccacaccacctcgagatttagactccaaggcttgcatttct
attggaaatcagaactttgaggtgaaggcagatgacctggagcctataatggaactggga
cgaggtgcgtacggggtggtggagaagatgcggcacgtgcccagcgggcagatcatggca
gtgaagcggatccgagccacagtaaatagccaggaacagaaacggctactgatggatttg
gatatttccatgaggacggtggactgtccattcactgtcaccttttatggcgcactgttt
cgggagggtgatgtgtggatctgcatggagctcatggatacatcactagataaattctac
aaacaagttattgataaaggccagacaattccagaggacatcttagggaaaatagcagtt
tctattgtaaaagcattagaacatttacatagtaagctgtctgtcattcacagagacgtc
aagccttctaatgtactcatcaatgctctcggtcaagtgaagatgtgcgattttggaatc
agtggctacttggtggactctgttgctaaaacaattgatgcaggttgcaaaccatacatg
gcccctgaaagaataaacccagagctcaaccagaagggatacagtgtgaagtctgacatt
tggagtctgggcatcacgatgattgagttggccatccttcgatttccctatgattcatgg
ggaactccatttcagcagctcaaacaggtggtagaggagccatcgccacaactcccagca
gacaagttctctgcagagtttgttgactttacctcacagtgcttaaagaagaattccaaa
gaacggcctacatacccagagctaatgcaacatccatttttcaccctacatgaatccaaa
ggaacagatgtggcatcttttgtaaaactgattcttggagactaa

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