| Entry |
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| Symbol |
PRNP, ASCR, AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, PrP27-30, PrP33-35C, PrPc, p27-30
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| Name |
(RefSeq) prion protein (Kanno blood group)
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| KO |
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| Organism |
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| Pathway |
| hsa05022 | Pathways of neurodegeneration - multiple diseases |
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| Network |
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| Element |
| N01197 | Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation |
| N01198 | Scrapie conformation PrPSc to PERK-ATF4 signaling pathway |
| N01199 | Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway |
| N01200 | Scrapie conformation PrPSc to transport of calcium |
| N01201 | Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway |
| N01202 | Oligomeric conformation PrPc to anterograde axonal transport |
| N01203 | Scrapie conformation PrPSc to Notch singling pathway |
| N01204 | PRNP-PI3K-NOX2 signaling pathway |
| N01205 | Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway |
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| Disease |
| H01243 | Huntington disease-like syndrome |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
5621 (PRNP)
09160 Human Diseases
09164 Neurodegenerative disease
05020 Prion disease
5621 (PRNP)
05022 Pathways of neurodegeneration - multiple diseases
5621 (PRNP)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:hsa04147]
5621 (PRNP)
04090 CD molecules [BR:hsa04090]
5621 (PRNP)
00536 Glycosaminoglycan binding proteins [BR:hsa00536]
5621 (PRNP)
00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
5621 (PRNP)
Exosome [BR:hsa04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
5621 (PRNP)
CD molecules [BR:hsa04090]
Proteins
5621 (PRNP)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate / Heparin
Others
5621 (PRNP)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:hsa00537]
Others
5621 (PRNP)
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| SSDB |
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| Motif |
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| Other DBs |
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| Structure |
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| Position |
20:4686456..4701588
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| AA seq |
253 aa
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQP
HGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGA
VVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCV
NITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPV
ILLISFLIFLIVG |
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| NT seq |
762 nt +upstreamnt +downstreamnt
atggcgaaccttggctgctggatgctggttctctttgtggccacatggagtgacctgggc
ctctgcaagaagcgcccgaagcctggaggatggaacactgggggcagccgatacccgggg
cagggcagccctggaggcaaccgctacccacctcagggcggtggtggctgggggcagcct
catggtggtggctgggggcagcctcatggtggtggctgggggcagccccatggtggtggc
tggggacagcctcatggtggtggctggggtcaaggaggtggcacccacagtcagtggaac
aagccgagtaagccaaaaaccaacatgaagcacatggctggtgctgcagcagctggggca
gtggtggggggccttggcggctacatgctgggaagtgccatgagcaggcccatcatacat
ttcggcagtgactatgaggaccgttactatcgtgaaaacatgcaccgttaccccaaccaa
gtgtactacaggcccatggatgagtacagcaaccagaacaactttgtgcacgactgcgtc
aatatcacaatcaagcagcacacggtcaccacaaccaccaagggggagaacttcaccgag
accgacgttaagatgatggagcgcgtggttgagcagatgtgtatcacccagtacgagagg
gaatctcaggcctattaccagagaggatcgagcatggtcctcttctcctctccacctgtg
atcctcctgatctctttcctcatcttcctgatagtgggatga |
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