KEGG   Homo sapiens (human): 5624
Entry
5624              CDS       T01001                                 
Symbol
PROC, APC, PC, PROC1, THPH3, THPH4
Name
(RefSeq) protein C, inactivator of coagulation factors Va and VIIIa
  KO
K01344  protein C (activated) [EC:3.4.21.69]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04610  Complement and coagulation cascades
Network
nt06514  Coagulation cascade
  Element
N01515  Regulation of coagulation cascade, protein C system
Disease
H00223  Inherited thrombophilia
H01723  Deep vein thrombosis
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    5624 (PROC)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5624 (PROC)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.69  protein C (activated)
     5624 (PROC)
Peptidases and inhibitors [BR:hsa01002]
 Serine peptidases
  Family S1: chymotrypsin family
   5624 (PROC)
SSDB
Motif
Pfam: Trypsin Gla FXa_inhibition hEGF EGF DUF1986 cEGF EGF_CA Trypsin_2 DL-JAG_EGF-like EGF_2 EGF_3 JAG1-like_EGF2 Plasmod_Pvs28
Other DBs
NCBI-GeneID: 5624
NCBI-ProteinID: NP_000303
OMIM: 612283
HGNC: 9451
Ensembl: ENSG00000115718
CPD: C22547
UniProt: P04070
Structure
Position
2:127418427..127429242
AA seq 461 aa
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
NT seq 1386 nt   +upstreamnt  +downstreamnt
atgtggcagctcacaagcctcctgctgttcgtggccacctggggaatttccggcacacca
gctcctcttgactcagtgttctccagcagcgagcgtgcccaccaggtgctgcggatccgc
aaacgtgccaactccttcctggaggagctccgtcacagcagcctggagcgggagtgcata
gaggagatctgtgacttcgaggaggccaaggaaattttccaaaatgtggatgacacactg
gccttctggtccaagcacgtcgacggtgaccagtgcttggtcttgcccttggagcacccg
tgcgccagcctgtgctgcgggcacggcacgtgcatcgacggcatcggcagcttcagctgc
gactgccgcagcggctgggagggccgcttctgccagcgcgaggtgagcttcctcaattgc
tcgctggacaacggcggctgcacgcattactgcctagaggaggtgggctggcggcgctgt
agctgtgcgcctggctacaagctgggggacgacctcctgcagtgtcaccccgcagtgaag
ttcccttgtgggaggccctggaagcggatggagaagaagcgcagtcacctgaaacgagac
acagaagaccaagaagaccaagtagatccgcggctcattgatgggaagatgaccaggcgg
ggagacagcccctggcaggtggtcctgctggactcaaagaagaagctggcctgcggggca
gtgctcatccacccctcctgggtgctgacagcggcccactgcatggatgagtccaagaag
ctccttgtcaggcttggagagtatgacctgcggcgctgggagaagtgggagctggacctg
gacatcaaggaggtcttcgtccaccccaactacagcaagagcaccaccgacaatgacatc
gcactgctgcacctggcccagcccgccaccctctcgcagaccatagtgcccatctgcctc
ccggacagcggccttgcagagcgcgagctcaatcaggccggccaggagaccctcgtgacg
ggctggggctaccacagcagccgagagaaggaggccaagagaaaccgcaccttcgtcctc
aacttcatcaagattcccgtggtcccgcacaatgagtgcagcgaggtcatgagcaacatg
gtgtctgagaacatgctgtgtgcgggcatcctcggggaccggcaggatgcctgcgagggc
gacagtggggggcccatggtcgcctccttccacggcacctggttcctggtgggcctggtg
agctggggtgagggctgtgggctccttcacaactacggcgtttacaccaaagtcagccgc
tacctcgactggatccatgggcacatcagagacaaggaagccccccagaagagctgggca
ccttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (27)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   PROTHERM (8)   
Protein sequence (23)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (21)   
DNA sequence (45)   
   RefSeq(nuc) (21)   
   GenBank (12)   
   EMBL (12)   
3D Structure (9)   
   PDB (9)   
Protein domain (14)   
   Pfam (14)   
All databases (131)   

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