KEGG   Homo sapiens (human): 56339
Entry
56339             CDS       T01001                                 
Symbol
METTL3, IME4, M6A, MT-A70, Spo8, hMETTL3
Name
(RefSeq) methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
  KO
K05925  mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
Organism
hsa  Homo sapiens (human)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:hsa03019]
    56339 (METTL3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.348  mRNA m6A methyltransferase
     56339 (METTL3)
Messenger RNA biogenesis [BR:hsa03019]
 Eukaryotic type
  mRNA processing factors
   3' end processing
    N6-methyltransferase complex
     56339 (METTL3)
SSDB
Motif
Pfam: MT-A70 DUF445
Other DBs
NCBI-GeneID: 56339
NCBI-ProteinID: NP_062826
OMIM: 612472
HGNC: 17563
Ensembl: ENSG00000165819
UniProt: Q86U44
Structure
Position
14:complement(21498138..21511340)
AA seq 580 aa
MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGG
PKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLL
QKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRA
EQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSK
KVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFR
RIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVG
GDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIP
VLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGK
EHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNV
QPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL
NT seq 1743 nt   +upstreamnt  +downstreamnt
atgtcggacacgtggagctctatccaggcccacaagaagcagctggactctctgcgggag
aggctgcagcggaggcggaagcaggactcggggcacttggatctacggaatccagaggca
gcattgtctccaaccttccgtagtgacagcccagtgcctactgcacccacctctggtggc
cctaagcccagcacagcttcagcagttcctgaattagctacagatcctgagttagagaag
aagttgctacaccacctctctgatctggccttaacattgcccactgatgctgtgtccatc
tgtcttgccatctccacgccagatgctcctgccactcaagatggggtagaaagcctcctg
cagaagtttgcagctcaggagttgattgaggtaaagcgaggtctcctacaagatgatgca
catcctactcttgtaacctatgctgaccattccaagctctctgccatgatgggtgctgtg
gcagaaaagaagggccctggggaggtagcagggactgtcacagggcagaagcggcgtgca
gaacaggactcgactacagtagctgcctttgccagttcgttagtctctggtctgaactct
tcagcatcggaaccagcaaaggagccagccaagaaatcaaggaaacatgctgcctcagat
gttgatctggagatagagagccttctgaaccaacagtccactaaggaacaacagagcaag
aaggtcagtcaggagatcctagagctattaaatactacaacagccaaggaacaatccatt
gttgaaaaatttcgctctcgaggtcgggcccaagtgcaagaattctgtgactatggaacc
aaggaggagtgcatgaaagccagtgatgctgatcgaccctgtcgcaagctgcacttcaga
cgaattatcaataaacacactgatgagtctttaggtgactgctctttccttaatacatgt
ttccacatggatacctgcaagtatgttcactatgaaattgatgcttgcatggattctgag
gcccctggcagcaaagaccacacgccaagccaggagcttgctcttacacagagtgtcgga
ggtgattccagtgcagaccgactcttcccacctcagtggatctgttgtgatatccgctac
ctggacgtcagtatcttgggcaagtttgcagttgtgatggctgacccaccctgggatatt
cacatggaactgccctatgggaccctgacagatgatgagatgcgcaggctcaacataccc
gtactacaggatgatggctttctcttcctctgggtcacaggcagggccatggagttgggg
agagaatgtctaaacctctgggggtatgaacgggtagatgaaattatttgggtgaagaca
aatcaactgcaacgcatcattcggacaggccgtacaggtcactggttgaaccatgggaag
gaacactgcttggttggtgtcaaaggaaatccccaaggcttcaaccagggtctggattgt
gatgtgatcgtagctgaggttcgttccaccagtcataaaccagatgaaatctatggcatg
attgaaagactatctcctggcactcgcaagattgagttatttggacgaccacacaatgtg
caacccaactggatcacccttggaaaccaactggatgggatccacctactagacccagat
gtggttgcacggttcaagcaaaggtacccagatggtatcatctctaaacctaagaattta
tag

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Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   OMIM (1)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (7)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (39)   
   RefSeq(nuc) (7)   
   GenBank (16)   
   EMBL (16)   
3D Structure (64)   
   PDB (64)   
Protein domain (2)   
   Pfam (2)   
All databases (145)   

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