KEGG   Homo sapiens (human): 5682
Entry
5682              CDS       T01001                                 
Symbol
PSMA1, HC2, HEL-S-275, NU, PROS30
Name
(RefSeq) proteasome 20S subunit alpha 1
  KO
K02725  20S proteasome subunit alpha 6 [EC:3.4.25.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5682 (PSMA1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5682 (PSMA1)
   05012 Parkinson disease
    5682 (PSMA1)
   05014 Amyotrophic lateral sclerosis
    5682 (PSMA1)
   05016 Huntington disease
    5682 (PSMA1)
   05017 Spinocerebellar ataxia
    5682 (PSMA1)
   05020 Prion disease
    5682 (PSMA1)
   05022 Pathways of neurodegeneration - multiple diseases
    5682 (PSMA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:hsa01002]
    5682 (PSMA1)
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5682 (PSMA1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:hsa04147]
    5682 (PSMA1)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.25  Threonine endopeptidases
    3.4.25.1  proteasome endopeptidase complex
     5682 (PSMA1)
Peptidases and inhibitors [BR:hsa01002]
 Threonine peptidases
  Family T1: proteasome family
   5682 (PSMA1)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Core particles (20S proteasome)
   alpha type subunits
    5682 (PSMA1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   5682 (PSMA1)
SSDB
Motif
Pfam: Proteasome Proteasome_A_N
Other DBs
NCBI-GeneID: 5682
NCBI-ProteinID: NP_002777
OMIM: 602854
HGNC: 9530
Ensembl: ENSG00000129084
UniProt: P25786
Structure
Position
11:complement(14504876..14643662)
AA seq 263 aa
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQ
KKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPT
QRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFM
ECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERP
QRKAQPAQPADEPAEKADEPMEH
NT seq 792 nt   +upstreamnt  +downstreamnt
atgtttcgaaatcagtatgacaatgatgtcactgtttggagcccccagggcaggattcat
caaattgaatatgcaatggaagctgttaaacaaggttcagccacagttggtctgaaatca
aaaactcatgcagttttggttgcattgaaaagggcgcaatcagagcttgcagctcatcag
aaaaaaattctccatgttgacaaccatattggtatctcaattgcggggcttactgctgat
gctagactgttatgtaattttatgcgtcaggagtgtttggattccagatttgtattcgat
agaccactgcctgtgtctcgtcttgtatctctaattggaagcaagacccagataccaaca
caacgatatggccggagaccatatggtgttggtctccttattgctggttatgatgatatg
ggccctcacattttccaaacctgtccatctgctaactattttgactgcagagccatgtcc
attggagcccgttcccaatcagctcgtacttacttggagagacatatgtctgaatttatg
gagtgtaatttaaatgaactagttaaacatggtctgcgtgccttaagagagacgcttcct
gcagaacaggacctgactacaaagaatgtttccattggaattgttggtaaagacttggag
tttacaatctatgatgatgatgatgtgtctccattcctggaaggtcttgaagaaagacca
cagagaaaggcacagcctgctcaacctgctgatgaacctgcagaaaaggctgatgaacca
atggaacattaa

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