KEGG   Homo sapiens (human): 57082
Entry
57082             CDS       T01001                                 
Symbol
KNL1, AF15Q14, CASC5, CT29, D40, MCPH4, PPP1R55, Spc7, hKNL-1, hSpc105
Name
(RefSeq) kinetochore scaffold 1
  KO
K11542  protein CASC5
Organism
hsa  Homo sapiens (human)
Pathway
hsa04110  Cell cycle
Network
nt06515  Regulation of kinetochore-microtubule interactions
  Element
N01526  Organization of the outer kinetochore
N01529  Recruitment and formation of the MCC
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    57082 (KNL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    57082 (KNL1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:hsa03036]
    57082 (KNL1)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     57082 (KNL1)
Chromosome and associated proteins [BR:hsa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    KMN network proteins
     57082 (KNL1)
SSDB
Motif
Pfam: MELT Knl1_RWD_C
Other DBs
NCBI-GeneID: 57082
NCBI-ProteinID: NP_733468
OMIM: 609173
HGNC: 24054
Ensembl: ENSG00000137812
UniProt: Q8NG31
Structure
Position
15:40594249..40664342
AA seq 2342 aa
MDGVSSEANEENDNIERPVRRRHSSILKPPRSPLQDLRGGNERVQESNALRNKKNSRRVS
FADTIKVFQTESHMKIVRKSEMEGCSAMVPSQLQLLPPGFKRFSCLSLPETETGENLLLI
QNKKLEDNYCEITGMNTLLSAPIHTQMQQKEFSIIEHTRERKHANDQTVIFSDENQMDLT
SSHTVMITKGLLDNPISEKSTKIDTTSFLANLKLHTEDSRMKKEVNFSVDQNTSSENKID
FNDFIKRLKTGKCSAFPDVPDKENFEIPIYSKEPNSASSTHQMHVSLKEDENNSNITRLF
REKDDGMNFTQCHTANIQTLIPTSSETNSRESKGNDITIYGNDFMDLTFNHTLQILPATG
NFSEIENQTQNAMDVTTGYGTKASGNKTVFKSKQNTAFQDLSINSADKIHITRSHIMGAE
THIVSQTCNQDARILAMTPESIYSNPSIQGCKTVFYSSCNDAMEMTKCLSNMREEKNLLK
HDSNYAKMYCNPDAMSSLTEKTIYSGEENMDITKSHTVAIDNQIFKQDQSNVQIAAAPTP
EKEMMLQNLMTTSEDGKMNVNCNSVPHVSKERIQQSLSNPLSISLTDRKTELLSGENMDL
TESHTSNLGSQVPLAAYNLAPESTSESHSQSKSSSDECEEITKSRNEPFQRSDIIAKNSL
TDTWNKDKDWVLKILPYLDKDSPQSADCNQEIATSHNIVYCGGVLDKQITNRNTVSWEQS
LFSTTKPLFSSGQFSMKNHDTAISSHTVKSVLGQNSKLAEPLRKSLSNPTPDYCHDKMII
CSEEEQNMDLTKSHTVVIGFGPSELQELGKTNLEHTTGQLTTMNRQIAVKVEKCGKSPIE
KSGVLKSNCIMDVLEDESVQKPKFPKEKQNVKIWGRKSVGGPKIDKTIVFSEDDKNDMDI
TKSYTIEINHRPLLEKRDCHLVPLAGTSETILYTCRQDDMEITRSHTTALECKTVSPDEI
TTRPMDKTVVFVDNHVELEMTESHTVFIDYQEKERTDRPNFELSQRKSLGTPTVICTPTE
ESVFFPGNGESDRLVANDSQLTPLEEWSNNRGPVEVADNMELSKSATCKNIKDVQSPGFL
NEPLSSKSQRRKSLKLKNDKTIVFSENHKNDMDITQSCMVEIDNESALEDKEDFHLAGAS
KTILYSCGQDDMEITRSHTTALECKTLLPNEIAIRPMDKTVLFTDNYSDLEVTDSHTVFI
DCQATEKILEENPKFGIGKGKNLGVSFPKDNSCVQEIAEKQALAVGNKIVLHTEQKQQLF
AATNRTTNEIIKFHSAAMDEKVIGKVVDQACTLEKAQVESCQLNNRDRRNVDFTSSHATA
VCGSSDNYSCLPNVISCTDNLEGSAMLLCDKDEEKANYCPVQNDLAYANDFASEYYLESE
GQPLSAPCPLLEKEEVIQTSTKGQLDCVITLHKDQDLIKDPRNLLANQTLVYSQDLGEMT
KLNSKRVSFKLPKDQMKVYVDDIYVIPQPHFSTDQPPLPKKGQSSINKEEVILSKAGNKS
LNIIENSSAPICENKPKILNSEEWFAAACKKELKENIQTTNYNTALDFHSNSDVTKQVIQ
THVNAGEAPDPVITSNVPCFHSIKPNLNNLNGKTGEFLAFQTVHLPPLPEQLLELGNKAH
NDMHIVQATEIHNINIISSNAKDSRDEENKKSHNGAETTSLPPKTVFKDKVRRCSLGIFL
PRLPNKRNCSVTGIDDLEQIPADTTDINHLETQPVSSKDSGIGSVAGKLNLSPSQYINEE
NLPVYPDEINSSDSINIETEEKALIETYQKEISPYENKMGKTCNSQKRTWVQEEEDIHKE
KKIRKNEIKFSDTTQDREIFDHHTEEDIDKSANSVLIKNLSRTPSSCSSSLDSIKADGTS
LDFSTYRSSQMESQFLRDTICEESLREKLQDGRITIREFFILLQVHILIQKPRQSNLPGN
FTVNTPPTPEDLMLSQYVYRPKIQIYREDCEARRQKIEELKLSASNQDKLLVDINKNLWE
KMRHCSDKELKAFGIYLNKIKSCFTKMTKVFTHQGKVALYGKLVQSAQNEREKLQIKIDE
MDKILKKIDNCLTEMETETKNLEDEEKNNPVEEWDSEMRAAEKELEQLKTEEEELQRNLL
ELEVQKEQTLAQIDFMQKQRNRTEELLDQLSLSEWDVVEWSDDQAVFTFVYDTIQLTITF
EESVVGFPFLDKRYRKIVDVNFQSLLDEDQAPPSSLLVHKLIFQYVEEKESWKKTCTTQH
QLPKMLEEFSLVVHHCRLLGEEIEYLKRWGPNYNLMNIDINNNELRLLFSSSAAFAKFEI
TLFLSAYYPSVPLPSTIQNHVGNTSQDDIATILSKVPLENNYLKNVVKQIYQDLFQDCHF
YH
NT seq 7029 nt   +upstreamnt  +downstreamnt
atggatggggtgtcttcagaggctaatgaagaaaatgacaatatagagagacctgttaga
agacggcattcttcaatattgaaacccccaaggagtcctcttcaggacctcagaggtggg
aatgaaagagttcaggaatccaatgctttgagaaataagaaaaactctcgtcgagtcagc
tttgcagatactataaaggtattccagacggagtctcatatgaaaatagtgagaaagtca
gaaatggaaggctgcagtgcaatggtgccatctcagctgcaacttctgcctcctgggttt
aagcgattctcctgcctcagcctcccagaaacagaaacaggagaaaatcttcttttgata
cagaataagaaattagaagataattactgtgaaattactgggatgaacacattgctttct
gctcccattcatacccagatgcaacagaaggagttttcaattatagaacatacccgtgaa
aggaaacatgcaaatgaccagacagtcattttttcagatgaaaaccagatggacctgaca
tcaagtcacactgtaatgattaccaaaggccttttagataatcccataagtgaaaagtcc
accaagatagataccacatcatttctagctaatttaaagcttcacaccgaggactcaaga
atgaaaaaagaagtaaatttttccgtggatcaaaacacttcttcagaaaataaaatagat
ttcaatgacttcataaaaagattgaaaacaggaaaatgtagtgcttttcctgatgtgcct
gataaagaaaattttgagatacctatttattccaaggaaccgaacagtgcctcttctaca
catcaaatgcatgtatctcttaaggaagatgaaaataacagtaatattactaggctcttt
agagaaaaagatgatgggatgaatttcacccagtgtcatacagccaatattcagacattg
attcccacatccagtgagaccaactcacgggaatctaaaggtaatgatattacaatttat
ggcaatgactttatggacttgacatttaaccacactttgcagatcttacctgcaacaggt
aatttttctgaaatagaaaatcaaactcagaatgccatggatgtaacaacaggttatgga
actaaagcttcaggaaataaaacagtttttaagagtaaacaaaatactgcttttcaagac
ctttccataaactctgcagacaaaatacatattaccagaagtcatattatgggggcagaa
actcacatagtctcacagacttgtaatcaggatgccagaatattagccatgaccccagaa
tctatatattctaatccatctattcaaggttgtaagactgttttctattctagttgtaat
gatgccatggaaatgaccaaatgtctctcaaatatgagagaggagaaaaatttgctaaag
catgacagtaattatgctaaaatgtattgcaatccagatgctatgtcttctctcacagag
aaaactatttattccggagaggagaacatggacattaccaagagtcatacagttgcaata
gataatcaaatttttaaacaagatcaatcaaatgtgcaaatagcagctgcaccaacaccc
gaaaaagaaatgatgctccaaaatcttatgaccacatcagaagatgggaaaatgaatgta
aattgtaactcagttcctcatgtatctaaggaaagaatacagcagagcctgtcaaatcct
ttgtctatttcattgactgatagaaagactgaactcttatcaggtgaaaatatggatttg
actgaaagtcacacaagtaacttaggaagtcaggttcctcttgcagcttataatctagca
ccggagagtaccagtgaatctcactctcagagcaaaagctcttcagatgaatgtgaagaa
attaccaaaagtcgtaatgaaccatttcagcgatcagacataatagccaaaaacagctta
accgacacctggaacaaagacaaagattgggttttgaagattttgccctaccttgataaa
gattctcctcagtcagctgattgtaatcaggagatagcaacaagccataatatagtctac
tgtggtggagttcttgataaacaaataactaatagaaatacagtatcatgggaacaatct
ttgttttctaccacaaagccattattttcatcaggacagttctctatgaaaaatcatgat
actgctataagtagtcatacagtgaaatctgtactaggccagaattctaaactggctgag
ccactgaggaaaagtttaagcaatcccacacctgactattgccatgacaagatgattata
tgttcagaggaagagcaaaatatggatctaacaaagagccacactgtcgtcattggattt
ggtccttctgaactacaagaacttggtaaaactaatttagaacacactactggccagcta
acaacaatgaacagacagatagctgtaaaagttgaaaaatgtggtaaaagtcccatagaa
aaaagtggagtgcttaaatctaactgtattatggatgtgttagaggacgaaagtgtacag
aaacctaaatttccaaaggaaaagcaaaatgtcaaaatttggggaaggaaaagtgttggt
ggaccaaaaattgataagactattgtattttcagaagacgataagaatgatatggatatc
actaagagttatacaatagaaataaaccatagacctttattagagaaacgtgattgtcat
ttggtgccattggcaggaacttctgaaactattttatatacatgtaggcaggatgacatg
gagatcactagaagtcacacaactgccttagaatgtaaaactgtctcaccagatgaaata
actactaggcctatggacaaaactgtagtgtttgtagataatcatgttgaactagaaatg
acagagtcccatactgttttcattgactaccaagaaaaggaaagaacagacagacctaac
tttgaactatcccaaaggaaaagcctaggaacaccaacagtgatatgtactcctactgag
gagagtgttttctttccaggaaatggtgaaagtgaccgtctagtagcaaatgacagccag
ctaacccctctggaggaatggtctaataataggggccctgtagaggtagctgataacatg
gaattgtctaaatcagccacttgcaaaaacatcaaagatgtacaaagtcctggatttctg
aatgaacctctatcaagcaaaagtcagagaagaaaaagccttaagctaaaaaatgacaag
accattgtattttcagagaatcataaaaatgatatggatattacccagagttgtatggtg
gaaatagataacgaaagtgccctggaggataaagaggacttccatttggcaggggcttct
aaaactattttgtattcatgtgggcaggatgacatggagatcactaggagtcacacaact
gccttagaatgtaaaactctcctgccaaatgaaatagctattaggcccatggacaaaacc
gtattgttcacagataattacagtgatctggaagtcaccgattcccatactgttttcatt
gactgtcaagccacagagaaaatacttgaagaaaaccctaaatttggaataggaaaagga
aaaaacttgggtgtttcctttcctaaggataatagctgtgttcaagaaatcgctgaaaaa
caagcactggctgtaggaaacaaaatagttcttcacaccgagcaaaagcaacaactcttt
gctgctactaatagaactactaatgaaatcatcaaatttcatagtgctgctatggatgaa
aaggtcatagggaaagttgtagaccaggcctgtacattggaaaaagcgcaagttgaaagc
tgtcagttaaataatagagatagaagaaatgtggactttacaagtagtcatgcaactgct
gtttgtggatccagtgataattattcctgtttaccaaatgttatttcctgtactgataat
ttggagggtagtgccatgctcttatgtgataaagatgaggaaaaagccaattattgccca
gtgcaaaatgatcttgcttatgcaaatgattttgccagtgaatattacttggaatctgag
ggacagcctctctctgctccttgtcctttgttagagaaggaagaagttattcaaaccagt
accaaaggacagttagactgtgttataacactgcacaaagatcaagatctgattaaggat
ccacgaaatctattggctaatcaaactttagtatatagtcaagatctgggggagatgact
aaacttaattcaaagcgagtatcttttaagcttccaaaggatcaaatgaaagtctatgtt
gatgacatttatgttattcctcagcctcatttctcaaccgaccaacctccattacctaaa
aaaggacagagtagtatcaataaagaagaagtaatactgtctaaagctggaaataagagt
ttaaatattatagaaaattcctctgcacccatatgtgaaaacaagcccaaaatactcaat
agtgaggaatggtttgctgcagcctgtaaaaaagaactgaaggaaaatattcaaacaact
aactataatacagctctagatttccacagtaactcagacgtaactaagcaagtcattcaa
actcatgtcaatgctggagaagcaccagatcctgtaattacatctaatgttccatgtttt
catagtatcaaaccaaatctgaataatttgaatggaaaaactggagagtttttagccttt
caaactgttcatctaccaccccttccagagcaattacttgaattaggaaataaggcacac
aatgatatgcatatagtgcaagctacagaaatacataatattaacataatctccagcaat
gctaaagatagtagagatgaggaaaataaaaagtctcataatggagctgaaaccacctct
ctaccgccaaagacagtttttaaagataaagtaaggagatgttctttgggaatctttttg
cctagattgcccaacaagagaaattgtagtgtcactggtattgatgacctggaacagatt
ccagcagacacaactgatataaatcacttagaaactcagccggtctctagcaaagattca
ggcattggatctgttgcaggtaaactgaacctaagtccttctcaatatataaatgaggaa
aatcttcctgtatatcctgatgagatcaattcttcagactctattaacatagaaactgag
gaaaaggccttgattgagacataccaaaaagagatttcaccatatgaaaataaaatggga
aaaacttgcaatagccaaaaaagaacgtgggtacaagaagaagaagatattcataaggag
aaaaaaatcagaaaaaatgagattaagtttagtgatacgacacaagatcgggagattttt
gatcaccatactgaagaggatatagataaaagtgctaacagtgtattgataaaaaacctg
agcaggaccccatctagttgcagcagctctctggattcaatcaaggctgatgggacctct
ctggacttcagcacttaccgcagtagtcaaatggaatcacagtttctcagagatactatt
tgtgaagagagcttgagggagaaactccaagatgggagaataacaataagggagttcttt
atacttctccaggtccacatcttgatacagaaaccccgacagagcaatctcccaggcaat
tttactgtaaacacaccacctactccagaagacctgatgttaagtcaatatgtttaccga
cccaagatacagatttatagagaagattgtgaggctcgtcgccaaaagattgaagaatta
aagctttctgcatcgaaccaagataagctgttggttgatataaataagaacctgtgggaa
aaaatgagacactgctctgacaaagagctgaaggcctttggaatttatcttaacaaaata
aagtcatgttttaccaagatgactaaagtcttcactcaccaaggaaaagtggctctgtat
ggcaagctggtgcagtcagctcagaatgagagggagaaacttcaaataaagatagatgag
atggataaaatacttaagaagatcgataactgcctcactgagatggaaacagaaactaag
aatttggaggatgaagagaaaaacaatcctgtggaagaatgggattctgaaatgagagct
gcagaaaaagaattggaacagctgaaaactgaagaagaggagcttcaaagaaatctctta
gaactggaggtacaaaaagagcagacccttgctcaaatagactttatgcaaaaacaaaga
aatagaactgaagagctactggatcagttgagcttgtctgagtgggatgtcgttgagtgg
agtgatgatcaagctgtattcacctttgtttatgacacgatacaactcaccatcaccttt
gaagagtcagttgttggtttccctttcctggacaagcgttataggaagattgttgatgtc
aattttcaatctctgttagatgaggatcaagctcctccttcctcccttttagttcataag
cttattttccagtacgttgaagaaaaggaatcctggaagaagacatgtacaacccagcat
cagttacccaagatgcttgaagaattctcactggtagtgcaccattgcagactccttgga
gaggagattgagtatttaaagagatggggaccaaattataacctaatgaacatagatatt
aataataatgaattgagacttttattctctagctccgcagcatttgcaaagtttgaaata
actttgtttctctcagcctattatccatctgtaccattaccttccaccattcagaatcac
gttgggaacactagccaagatgatattgctaccattctatctaaagtgccactggagaac
aactacctgaagaatgtagtcaagcaaatttaccaagatctgtttcaggactgccatttc
taccactag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (3)   
   KEGG NETWORK (3)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (44)   
   KEGG ORTHOLOGY (1)   
   RefGene (38)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (28)   
   RefSeq(nuc) (4)   
   GenBank (12)   
   EMBL (12)   
3D Structure (4)   
   PDB (4)   
Protein domain (2)   
   Pfam (2)   
All databases (94)   

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