KEGG   Homo sapiens (human): 5709
Entry
5709              CDS       T01001                                 
Symbol
PSMD3, P58, RPN3, S3, TSTA2
Name
(RefSeq) proteasome 26S subunit, non-ATPase 3
  KO
K03033  26S proteasome regulatory subunit N3
Organism
hsa  Homo sapiens (human)
Pathway
hsa03050  Proteasome
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05016  Huntington disease
hsa05017  Spinocerebellar ataxia
hsa05020  Prion disease
hsa05022  Pathways of neurodegeneration - multiple diseases
hsa05169  Epstein-Barr virus infection
Network
nt06460  Alzheimer disease
nt06461  Huntington disease
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06465  Prion disease
nt06466  Pathways of neurodegeneration
  Element
N01029  26S proteasome-mediated protein degradation
N01030  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation
N01060  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation
N01061  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation
N01144  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation
N01145  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation
N01146  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation
N01197  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03050 Proteasome
    5709 (PSMD3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    5709 (PSMD3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    5709 (PSMD3)
   05012 Parkinson disease
    5709 (PSMD3)
   05014 Amyotrophic lateral sclerosis
    5709 (PSMD3)
   05016 Huntington disease
    5709 (PSMD3)
   05017 Spinocerebellar ataxia
    5709 (PSMD3)
   05020 Prion disease
    5709 (PSMD3)
   05022 Pathways of neurodegeneration - multiple diseases
    5709 (PSMD3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03051 Proteasome [BR:hsa03051]
    5709 (PSMD3)
Proteasome [BR:hsa03051]
 Eukaryotic proteasome
  Regulatory particles
   PA700 (19S proteasome)
    non-ATPase subunits
     5709 (PSMD3)
SSDB
Motif
Pfam: Rpn3_C PCI CSN8_PSD8_EIF3K TPR_2
Other DBs
NCBI-GeneID: 5709
NCBI-ProteinID: NP_002800
OMIM: 617676
HGNC: 9560
Ensembl: ENSG00000108344
UniProt: O43242
Structure
Position
17:39980807..39997959
AA seq 534 aa
MKQEGSARRRGADKAKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGKTAAAAA
EHSQRELDTVTLEDIKEHVKQLEKAVSGKEPRFVLRALRMLPSTSRRLNHYVLYKAVQGF
FTSNNATRDFLLPFLEEPMDTEADLQFRPRTGKAASTPLLPEVEAYLQLLVVIFMMNSKR
YKEAQKISDDLMQKISTQNRRALDLVAAKCYYYHARVYEFLDKLDVVRSFLHARLRTATL
RHDADGQATLLNLLLRNYLHYSLYDQAEKLVSKSVFPEQANNNEWARYLYYTGRIKAIQL
EYSEARRTMTNALRKAPQHTAVGFKQTVHKLLIVVELLLGEIPDRLQFRQPSLKRSLMPY
FLLTQAVRTGNLAKFNQVLDQFGEKFQADGTYTLIIRLRHNVIKTGVRMISLSYSRISLA
DIAQKLQLDSPEDAEFIVAKAIRDGVIEASINHEKGYVQSKEMIDIYSTREPQLAFHQRI
SFCLDIHNMSVKAMRFPPKSYNKDLESAEERREREQQDLEFAKEMAEDDDDSFP
NT seq 1605 nt   +upstreamnt  +downstreamnt
atgaagcaggagggctcggcgcggcgccgcggcgcggacaaggcgaaaccgccgcccggc
ggaggagaacaagaacccccaccgccgccggccccccaggatgtggagatgaaagaggag
gcagcgacgggtggcgggtcgacgggggaggcagacggcaagacggcggcggcagcggct
gagcactcccagcgagagctggacacagtcaccttggaggacatcaaggagcacgtgaaa
cagctagagaaagcggtttcaggcaaggagccgagattcgtgctgcgggccctgcggatg
ctgccttccacatcacgccgcctcaaccactatgttctgtataaggctgtgcagggcttc
ttcacttcaaataatgccactcgagactttttgctccccttcctggaagagcccatggac
acagaggctgatttacagttccgtccccgcacgggaaaagctgcgtcgacacccctcctg
cctgaagtggaagcctatctccaactcctcgtggtcatcttcatgatgaacagcaagcgc
tacaaagaggcacagaagatctctgatgatctgatgcagaagatcagtactcagaaccgc
cgggccctagaccttgtagccgcaaagtgttactattatcacgcccgggtctatgagttc
ctggacaagctggatgtggtgcgcagcttcttgcatgctcggctccggacagctacgctt
cggcatgacgcagacgggcaggccaccctgttgaacctcctgctgcggaattacctacac
tacagcttgtacgaccaggctgagaagctggtgtccaagtctgtgttcccagagcaggcc
aacaacaatgagtgggccaggtacctctactacacagggcgaatcaaagccatccagctg
gagtactcagaggcccggagaacgatgaccaacgcccttcgcaaggcccctcagcacaca
gctgtcggcttcaaacagacggtgcacaagcttctcatcgtggtggagctgttgctgggg
gagatccctgaccggctgcagttccgccagccctccctcaagcgctcactcatgccctat
ttccttctgactcaagctgtcaggacaggaaacctagccaagttcaaccaggtcctggat
cagtttggggagaagtttcaagcagatgggacctacaccctaattatccggctgcggcac
aacgtgattaagacaggtgtacgcatgatcagcctctcctattcccgaatctccttggct
gacatcgcccagaagctgcagttggatagccccgaagatgcagagttcattgttgccaag
gccatccgggatggtgtcattgaggccagcatcaaccacgagaagggctatgtccaatcc
aaggagatgattgacatctattccacccgagagccccagctagccttccaccagcgcatc
tccttctgcctagatatccacaacatgtctgtcaaggccatgaggtttcctcccaaatcg
tacaacaaggacttggagtctgcagaggaacggcgtgagcgagaacagcaggacttggag
tttgccaaggagatggcagaagatgatgatgacagcttcccttga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (9)   
Network (14)   
   KEGG NETWORK (14)   
Disease (1)   
   OMIM (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (40)   
   KEGG ORTHOLOGY (1)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (11)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (41)   
   RefSeq(nuc) (1)   
   GenBank (20)   
   EMBL (20)   
3D Structure (52)   
   PDB (52)   
Protein domain (4)   
   Pfam (4)   
All databases (167)   

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