KEGG   Homo sapiens (human): 57176
Entry
57176             CDS       T01001                                 
Symbol
VARS2, COXPD20, VALRS, VARS2L, VARSL
Name
(RefSeq) valyl-tRNA synthetase 2, mitochondrial
  KO
K01873  valyl-tRNA synthetase [EC:6.1.1.9]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H00891  Combined oxidative phosphorylation deficiency
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    57176 (VARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    57176 (VARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    57176 (VARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.9  valine---tRNA ligase
     57176 (VARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (U)
   57176 (VARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Other AARSs
    57176 (VARS2)
 Prokaryotic type
    57176 (VARS2)
SSDB
Motif
Pfam: tRNA-synt_1 Anticodon_1 tRNA-synt_1g tRNA-synt_1_2 tRNA-synt_1e FmiP_Thoc5 tRNA-synt_1b tRNA-synt_1f
Other DBs
NCBI-GeneID: 57176
NCBI-ProteinID: NP_065175
OMIM: 612802
HGNC: 21642
Ensembl: ENSG00000137411
UniProt: Q5ST30 B4E0K6 B4DG77
Position
6:30914238..30926459
AA seq 1063 aa
MPHLPLASFRPPFWGLRHSRGLPRFHSVSTQSEPHGSPISRRNREAKQKRLREKQATLEA
EIAGESKSPAESIKAWRPKELVLYEIPTKPGEKKDVSGPLPPAYSPRYVEAAWYPWWVRE
GFFKPEYQARLPQATGETFSMCIPPPNVTGSLHIGHALTVAIQDALVRWHRMRGDQVLWV
PGSDHAGIATQAVVEKQLWKERGVRRHELSREAFLREVWQWKEAKGGEICEQLRALGASL
DWDRECFTMDVGSSVAVTEAFVRLYKAGLLYRNHQLVNWSCALRSAISDIEVENRPLPGH
TQLRLPGCPTPVSFGLLFSVAFPVDGEPDAEVVVGTTRPETLPGDVAVAVHPDDSRYTHL
HGRQLRHPLMGQPLPLITDYAVQPHVGTGAVKVTPAHSPADAEMGARHGLSPLNVIAEDG
TMTSLCGDWLQGLHRFVAREKIMSVLSEWGLFRGLQNHPMVLPICSRSGDVIEYLLKNQW
FVRCQEMGARAAKAVESGALELSPSFHQKNWQHWFSHIGDWCVSRQLWWGHQIPAYLVVE
DHAQGEEDCWVVGRSEAEAREVAAELTGRPGAELTLERDPDVLDTWFSSALFPFSALGWP
QETPDLARFYPLSLLETGSDLLLFWVGRMVMLGTQLTGQLPFSKVLLHPMVRDRQGRKMS
KSLGNVLDPRDIISGVEMQVLQEKLRSGNLDPAELAIVAAAQKKDFPHGIPECGTDALRF
TLCSHGVQAGDLHLSVSEVQSCRHFCNKIWNALRFILNALGEKFVPQPAEELSPSSPMDA
WILSRLALAAQECERGFLTRELSLVTHALHHFWLHNLCDVYLEAVKPVLWHSPRPLGPPQ
VLFSCADLGLRLLAPLMPFLAEELWQRLPPRPGCPPAPSISVAPYPSACSLEHWRQPELE
RRFSRVQEVVQVLRALRATYQLTKARPRVLLQSSEPGDQGLFEAFLEPLGTLGYCGAVGL
LPPGAAAPSGWAQAPLSDTAQVYMELQGLVDPQIQLPLLAARRYKLQKQLDSLTARTPSE
GEAGTQRQQKLSSLQLELSKLDKAASHLRQLMDEPPAPGSPEL
NT seq 3192 nt   +upstreamnt  +downstreamnt
atgcctcatttgcctctcgcctcttttcgaccaccattttgggggctgaggcactcacgg
ggcctccccaggtttcactccgtttctacacagtcggagccccatggatctcccatctcc
cggaggaaccgtgaagccaaacagaagcgcctgcgagagaagcaggcgactctggaggct
gagatagcaggggagagcaagtcacctgcagaatccattaaggcctggaggcctaaggag
ttagtattgtatgaaatccctacgaaacccggtgaaaagaaagatgtctctgggcccctg
cctcctgcatacagcccccgatatgttgaggctgcctggtacccgtggtgggtacgagag
ggcttcttcaaaccagaatatcaggcccggctgccccaagctacaggggagaccttttcc
atgtgtatcccacctcccaatgtcactggctccctgcacattggccacgcactcacggtg
gccatacaggatgccctcgtgcgctggcaccggatgcgtggggatcaagtgctgtgggtc
cctggttcagatcatgcaggaattgctacacaagctgtggtggagaaacaactgtggaag
gaacggggagtgaggagacatgagctgagccgggaggccttccttagggaggtgtggcag
tggaaggaggcgaaaggtggagagatctgtgagcagctgcgagctctgggtgcctccctg
gactgggatcgagagtgttttaccatggatgttggctcctcagtggctgtgactgaagct
tttgtgcggctctacaaggcggggttgctgtaccggaaccatcagcttgtcaactggtca
tgtgctttaagatcagccatctcggacattgaggtggagaaccggcccctgcctggccac
acacagcttcgactgcctggctgccccacccccgtgtcttttggcctcctattttctgtt
gccttccccgtggatggagagcctgatgcagaggttgtggtaggaaccacaaggccagag
acgctgcctggagatgtggctgtggccgttcatccagacgactcgcgatacacacatcta
cacgggcgacagcttcgtcaccccttgatggggcagcctcttcccctcatcacagactat
gctgttcagccacatgtgggcacgggggcagtgaaggtgactccagctcacagtcctgcc
gatgctgagatgggggcccgacatggcttgagccccttgaatgtcattgcggaggatggg
accatgacctccctctgcggggactggctgcagggtcttcaccggtttgtggcccgggaa
aagataatgtctgtgctgagtgaatggggcctgttccggggcctccagaaccaccccatg
gtactgcccatctgcagccgttctggggatgtgatagaatacctgctgaagaaccagtgg
tttgtccgctgccaggaaatgggggcccgagctgccaaggctgtggagtcgggggccctg
gagctcagtccctccttccaccagaagaactggcagcactggttttcccatattggggac
tggtgtgtctcccggcagctgtggtggggccatcagattccagcctacctggttgtagag
gaccatgcgcagggagaagaggactgttgggtggttgggcggtcagaggctgaggccaga
gaggtagcagcggaactgacagggaggccaggggcagagctgaccctggagagggatcct
gatgtcctagacacatggttttcttctgccctgttccccttttctgccctgggctggccc
caagagaccccagaccttgctcgtttctaccccctgtcacttttggaaacgggcagcgac
cttctgctgttctgggtgggccgcatggtcatgttggggacccagctcacagggcagctg
cccttcagcaaggtgcttcttcatcccatggttcgggacaggcagggccggaagatgagc
aagtccctggggaatgtgctggacccaagagacatcatcagtggggtggagatgcaggtg
ctgcaggaaaagctgagaagcggaaatttggaccctgcagagctggccattgtggctgca
gcacagaaaaaggactttcctcacgggatccctgagtgtgggacagatgccctgagattc
acactctgctcccatggagttcaggcgggcgacttgcacctgtcagtctctgaggtccag
agctgccgacatttctgcaacaagatctggaatgctcttcgctttatcctcaatgcttta
ggggagaaatttgtgccacagcctgctgaggagctgtctccctcctccccgatggatgcc
tggatcctgagccgccttgccctggctgcccaggagtgtgagcggggcttcctcacccga
gagctctcgctcgtcactcatgccctgcaccacttctggcttcacaacctctgtgacgtc
tacctggaggctgtgaagcccgtgctgtggcactcgccccgccccctggggccccctcag
gtcctgttctcctgcgctgacctcggcctccgcctcctggccccactgatgcccttcctg
gctgaagagctctggcagaggctgccccccaggcctggttgcccccctgcccccagcatc
tcggttgccccctaccccagcgcctgcagcttggagcactggcgccagccagagctggag
cggcgcttctcccgggtccaagaggtcgtgcaggtgctaagggctctccgagccacgtac
cagctcaccaaagcccggccccgagtgctgctgcagagctcagagcctggggaccagggc
ctcttcgaggccttcttggagcccctgggcaccctgggctactgtggggctgtgggcctg
ttacccccaggcgcagcagctccctccggctgggcccaggctccactcagtgacacggct
caagtctacatggagctgcagggcctggtggacccgcagatccagctacctctgttagcc
gcccgaaggtacaagttgcagaagcagcttgacagcctcacagccaggaccccatcagaa
ggggaggcagggactcagaggcaacaaaagctttcttccctccagctggaattgtcaaaa
ctggacaaggcagcctctcacctccggcagctgatggatgagcctccagccccagggagc
ccggagctctaa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (23)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (4)   
   OC (1)   
Protein sequence (7)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (47)   
   RefSeq(nuc) (3)   
   GenBank (22)   
   EMBL (22)   
Protein domain (8)   
   Pfam (8)   
All databases (102)   

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